Asam Traneksamat Oral Sebagai Terapi Melasma

Putri Wulandari

Abstract

Melasma adalah kelainan pigmentasi kulit didapat yang bersifat kronis, cenderung rekuren, serta sulit diobati. Asam traneksamat telah dilaporkan dapat menurunkan skor MASI dan memberikan perbaikan klinis.

Melasma is an acquired chronic skin pigmentation disorder, tend to recur, and difficult to treat. Oral tranexamic acid has been reported can reduce MASI score and give clinical improvement.

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References

Lily S. Kelainan Pigmen. Ilmu Penyakit Kulit dan Kelamin. 2016. ed 7. Jakarta:FKUI;342-45

Shet VM, Pandya AG. Melasma: a comprehensive update. J Am Acad Dermatol. 2011;65:689-96

Ogbechie-Godec OA, Elbuluk N. Melasma: an Up-to-Date Comprehensive Review. Dermatol Ther (Heidelb). 2017;7(3):305-18

Hilde L, Barbara B, Sofie DS, Evelien V, Mieille VG, et al. Hypomelanoses and Hypermelanoses. Fitzpatrick’s Dermatology in General Medicine. 2012. 8th edition. New York:McGraw Hill;819-20

Melyawati, Lis SS, Irma B, Lili L. Perkembangan Terbaru Etiopatogenesis Melasma. MDVI. 2014;41(3):133-38

Rashmi S, Pooja A, Vijay KG, Sidharth S, Narendra G. Melasma Update. Indian Dermatol Online J. 2014;5(4):426-35

Rupali D, Bhushan M, Adarsh LS. Correlation of clinicodermatoscopic and Wood’s lamp Findings in patients having melasma. Pigment Int. 2018;5:91-5

Ryski MN, Rahmadewi, Hari S. Gambaran Dermoskopi dan Lampu Wood pada Melasma. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2017;29(1):8-15

Sidarhart S, Abhijeet KJ, Sonali L. Dermoscopy of Melasma. Indian Dermatol Online J. 2017;8(6):525-26

Pandya AG, Hynan LS, Bhore R, et al. Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method. J Am Acad Dermatol. 2011;64(1):78-83.e2

Grimes PE, Ijaz S, Nashawati R, Kwak D. New oral and topical approaches for the treatment of melasma. Int J Women Dermatol. 2019;5(1):30-36

Grimes PE. Melasma: Etiologic and therapeutic considerations. Arch Dermatol. 1995;131(12):1453–7.

Grimes PE. Management of hyperpigmentation in darker racial ethnic groups. Semin Cutan Med Surg. 2009;28(2):77–85.

Halder RM, Grimes PE, McLaurin CI, Kress MA, Kenney Jr JA. Incidence of common dermatoes in a predominantly black dermatologic practice. Cutis. 1983;32(4):388–90.

Kim EH, Kim YC, Lee ES, Kang HY. The vascular characteristics of melasma. J Dermatol Sci. 2007;46(2):111–6.

Moin A, Jabery Z, Fallah N. Prevalence and awareness of melasma during pregnancy. Int J Dermatol. 2006;45(3):285–8.

Werlinger KD, Guevara IL, González CM, Rincón ET, Caetano R, Haley RW, et al. Prevalence of self-diagnosed melasma among premenopausal Latino women in Dallas and Fort Worth. Tex Arch Dermatol 2007;143(3):424–5.

Nordlund JJ, Grimes PE, Ortonne JP. The safety of hydroquinone. J Eur Acad Dermatology Venereol. 2006;20(7):781-787

Tse TW. Hydroquinone for skin lightening: Safety profile, duration of use and when should we stop? J Dermatolog Treat. 2010;21(5):272-275

Prachi AB, Vijay PZ, Kiran VG, Sharmila PP, Nitin JN, Manjyot MG. Exogenous Ochronosis. Indian Dermatol Online J. 2015;60(6):537-43

Frea AT, Sawitri, Hari S. Penurunan Skor Melasma Area and Severity Index (MASI) antara Asam Traneksamat Topikal dan Modifikasi Formula Kligman dengan Plasebo Topikal dan Modifikasi Formula Kligman pada Pasien. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2018;30(3):231-39

Bala HR, Lee S, Wong C, Pandya AG, Rodrigues M. Oral Tranexamic Acid for the Treatment of Melasma: A Review. Dermatol Surg. 2018;44(6):814-825

Tulika R. Role of Tranexamic Acid in Management of Melasma. J Cosmetol. 2017;1(1)

Tse TW, Hui E. Tranexamic acid: An important adjuvant in the treatment of melasma. J Cosmet Dermatol. 2013;12(1):57-66

Cho HH, Choi M, Cho S, Lee JH. Role of oral tranexamic acid in melasma patients treated with IPL and low fluence QS Nd:YAG laser. J Dermatolog Treat. 2013;24(4):292-296.

Li Y, Sun Q, He Z, Fu L, et al. Treatment of melasma with oral administration of compound tranexamic acid: a preliminary clinical trial. J Eur Acad Dermatol Venereol. 2014;28:393-4

Wu S, Shi H, Wu H. Treatment of Melasma With Oral Administration of Tranexamic Acid. Aesth Plast Surg. 2012:964-970.

Hwee CL, Tien GST, Cee LG. Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis. J Am Acad Dermatol. 2016;75(2):385-92

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