Potensi Kurkumin Kombinasi Silibinin (Cur-Sil)-Loaded Nanopartikel Magnetik (Fe3O4) Termodifikasi [Poly(Ethyelene Caprolactone)-Poly(Ethyelene Glycol) (PCL-PEG)] Ko-polimer sebagai Inhibitor Gen Leptin dalam Tata Laksana Kanker Paru

Ayu Dilia Febriani Wisnawa


Pendahuluan: Kanker paru merupakan kanker dengan insiden paling tinggi dan menyebabkan mortalitas yang signifikan pada pria. Leptin, sitokin derivat adiposit, memainkan peran penting pada proses karsinogenesis kanker paru. Kurkumin dan silibinin adalah komponen herbal alami dengan karakteristik antikanker bersifat multitarget. Diskusi: Teknologi nanopartikel magnetik (Fe3O4) memiliki sifat super-paramagnetik yang unik, sehingga meningkatkan kemampuan untuk mencapai target spesifik. Nanopartikel magnetik dilapisi dengan kopolimer polyethylene-caprolactone-polyethylene glycol (PCL-PEG) untuk meningkatkan stabilitas dan mengeliminasi kemungkinan agregasi permukaan substansi kurkumin dan silibinin yang dilapisi nanopartikel. Subtansi kurkumin dan silibinin dalam nanopartikel magnetik (Fe3O4) berbasis PCL-PEG termodifikasi digunakan sebagai inhibitor ekspresi leptin. Simpulan: Tinjauan pustaka menunjukkan berbagai manfaat farmakologi kurkumin dan silibinin ter-enkapsulasi nanopartikel magnetik berbasis kopolimer PCL-PEG termodifikasi sebagai inhibitor ekspresi leptin yang efektif tanpa toksisitas pada jaringan normal. Penemuan ini dapat digunakan sebagai alternatif tata laksana kanker paru di Indonesia.

Introduction: Lung cancer is the highest incidence of cancer and causes significant mortality in male. Leptin, an adipocyte derivative cytokine, plays a role in carcinogenesis in lung cancer. Curcumin (CUR) and silibinin (SIL) are natural herbal compounds with multitargeted anticancer properties. Discussion: Magnetic nanoparticle (Fe3O4) technology has unique super-paramagnetic properties, increasing the ability to reach specific targets. Magnetic nanoparticles are coated with polyethylene-caprolactone-polyethylene glycol (PCL-PEG) copolymers to improve stability and to eliminate the possibility of surface aggregation of nanoparticles-load curcumin and silibinin substances. The modified PCL-PEG-based magnetic nanoparticles (Fe3O4) of curcumin and silibinin are used as inhibitors of leptin expression.  Conclusion: Literature studies reveal various pharmacological advantages of curcumin and silibinin encapsulated with modified PCL-PEG copolymers magnetic nanoparticles as effective inhibitors in leptin expression without toxicity in normal tissue. It can be used as an alternative in lung cancer management in Indonesia.

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