Perdarahan Neonatus Akibat Defisiensi Vitamin K: Diagnosis, Tata Laksana, dan Pencegahan

Jadei Irene Linardi

Abstract

Perdarahan neonatus akibat defisiensi vitamin K (PDVK) merupakan salah satu gangguan koagulasi didapat, dengan manifestasi tidak spesifik. Perdarahan dapat bervariasi mulai dari perdarahan kulit hingga perdarahan intrakranial yang mengancam jiwa. Terdapat 3 bentuk klinis PDVK, yaitu onset dini, klasik, dan lambat. Tata laksana meliputi pemberian vitamin K dan/atau fresh frozen plasma (FFP). Pencegahan dengan vitamin K profilaksis pada bayi baru lahir.

 

Vitamin K deficiency bleeding (VKDB) in newborn is an acquired coagulation disorder with nonspecific clinical manifestations. The symptoms are from skin bleeding to a life-threatening intracranial bleeding. Three types of VKDB according to its onset are early, classic and late type. Proper managements of VKDB include administration of vitamin K and/or fresh frozen plasma (FFP). Prevention can be done by giving vitamin K prophylaxis in newborn. 

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References

Kliegman RM, Stanton BF, St Geme JW, Schor NF. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier; 2016.

Jaffray J, Young G, Ko RH. The bleeding newborn: A review of presentation, diagnosis, and management. Semin Fetal Neonatal Med. 2016;21(1):44-9. doi: 10.1016/j.siny.2015.12.002.

Permono HB, Sutaryo, Ugrasena IDG, Windiastuti E, Abdulsalam M, eds. Buku ajar hematologi-onkologi anak. Jakarta: Badan Penerbit IDAI; 2012.

Dirjen Bina Gizi dan Kesehatan Ibu dan Anak Kementerian Kesehatan Republik Indonesia. Pedoman teknis pemberian injeksi vitamin K1 profilaksis pada bayi baru lahir. Jakarta: Departemen Kesehatan Republik Indonesia; 2011.

Sumardi FS, Bisri DY, Bisri T. Hematoma subdural pada bayi dengan acquired prothrombine complex deficiency (APCD) syndrome di RS Hasan Sadikin dari Juli 2010 sampai Februari 2011. JNI. 2012;1(4):99-105.

Araki S, Shirahata A. Vitamin K deficiency bleeding in infancy. Nutrients 2020;12(780):1-13.

Lippi G, Franchini M. Vitamin K in neonates: Facts and myths. Blood Transfus. 2011;9:4-9.

Shearer MJ. Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev. 2009;23:45-59.

Gleason CA, Devaskar SU, eds. Avery’s diseases of the newborn. 9th ed. Philadelphia: Elsevier; 2012.

Boonchian P, Sutthichai J. Risk factors of acquired prothrombin complex deficiency syndrome: A case-control study. J Med Assoc Thai. 2008;91(Suppl 3):1-8.

Tertia C, Yoesdyanto K, Irfani I, Sembiring H. Laporan kasus: Perdarahan intraserebral pada acquired prothrombin complex deficiency onset lambat. Callosum Neurology. 2018;1(2):65-70.

Cloherty JP, Eichenwald EC, Hansen AR, Stark AR, eds. Manual of neonatal care. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2012.

Ervani N, Lubis BM, Azlin E, Tjipta GD, Emsyah L. Comparison of the effect of oral multiple dose with single intramuscular vitamin K1 administration on prothrombin time in term baby. Paediatr Indones. 2009;49:281-5.

Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK. Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: A systematic review. J Perinatol. 2016;36:29-34.

Weddle M, Empey A, Crossen E, Green A, Green J, Phillipi CA. Are pediatricians complicit in vitamin K deficiency bleeding? Pediatrics 2015;136(4):753-7.

Löwensteyn YN, Jansen NJG, van Heerde M, Klein RH, Kneyber MCJ, Kuiper JW, et al. Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk. Eur J Pediatr. 2019;178:1033-42.

Limantara VL, Suraatmaja S, Mudita IB, Retayasa W, Kardana M. Effect of oral vitamin K prophylaxis on prothrombine time and activated partial thromboplastin time: A randomized controlled comparison with an intramuscular vitamin K in infants. Paediatr Indones. 2007;47(3):109-4.

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