Vitamin D dan COVID-19: Tinjauan Literatur

Niluh Ayu Sri Saraswati, Devinqa Adhimah Amanda, Henry Wijaya

Abstract

Pendahuluan: Penyakit coronavirus (COVID-19) merupakan penyakit infeksi yang dideklarasikan WHO sebagai kasus gawat darurat kesehatan di dunia. Vitamin D diketahui memegang peranan dalam regulasi sistem imun baik pada penyakit infeksi maupun penyakit autoimun, sehingga
vitamin D dapat bermanfaat pada tata laksana COVID-19. Metode: Tinjauan literatur COVID-19 dan kaitannya dengan vitamin D; sumber data dari Google Cendekia, PubMed, dan WHO. Hasil: Vitamin D berperan mengendalikan sistem sel imun seperti makrofag, limfosit, neutrofil, dan
sel dendritik. Selain itu, mekanisme kerja innate dan adaptive immune system diperantarai oleh vitamin D, menghasilkan keseimbangan respons imun untuk meningkatkan respons anti-inflamasi. Simpulan: Vitamin D berkaitan dengan infeksi COVID-19 (dapat mengurangi risiko infeksi,
mencegah perkembangan infeksi, dapat menurunkan tingkat keparahan, dan meringankan komplikasi badai sitokin; dengan demikian, dapat menurunkan morbiditas dan mortalitas akibat infeksi COVID-19.

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