Collodion Baby

A. A. Made Berastia Anis Savitri,, Ida Ayu Sri Kusuma Dewi


Collodion baby (CB) is a rare dermatological condition worldwide of 1: 300.000 birth. A Collodion baby is a newborn whose entire body is covered with an adherent, supple, parchment-like membrane. Collodion baby in a manifestation of various hereditary conditions, including Harlequin orchestras’ (HI), lamelar orchestras’ (LI), non-bullous congenital ichtyosiform erythroderma (NBCIE), trichothiodystrophy metabolic disease, and endocrine disease. We report two collodion babies cases with peeling skin, passive movement, and poor feeding. Both cases were hospitalized in the humidity-controlled incubator. Water and topical treatment were used for daily bathing to prevent infection.

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Tuzun Y, Iscimen A, Pehlivan O. Collodion baby. J Turk Acad Dermatol. 2008;2(2):82201.

Prado R, Ellis LZ, Gamble R, Funk T, Arbuckle HA, Bruckner Al. Collodion baby: An update with a focus on practical management. J Am Acad Dermatol. 2012;67:1362-74.

Van Gysel D, Lijnen RL, Moekti SS, de Laat PC, Oranje AP. Collodion baby: A follow-up study of 17 cases. J Eur Acad Dermatol Venerol. 2002;16(5):472-5.

Dyer JA, Spraker M, Williams M. Care of the newborn with ichthyosis. Dermatol Ther. 2013;26(1):1-15.

Akiyama M. Updated molecular genetics and pathogenesis of ichthyoses. Nagoya J Med Sci 2011;73:79-90

Rimoin L, Graham JM. Ichthyotic skin disorders in the neonate. Clin Pediatr (Phila) 2012;51(8): 796-800.

Raghunath M, Hennies HC. Self-healing collodion baby: A dynamic phenothype explained by a particular transglutaminase-1 mutation. J Investig Dermatol. 2003;120:224-8.

Cao X, Lin Z, Yang H. New mutations in the transgulataminase 1 gene in three families with lamelar ichthyosis. J Clin Exp Dermatol Res. 2009;34:904-9.

Simalti AK, Sethi H. Collodion baby. Med J Armed Forces India 2017;73:197-9.

Nguyen MA, Gelman A, Norton SA. Practical events in the management of a collodion baby. JAMA Dermatol. 2015;151(9):1031-2

Elias S, Mazur M, Sabbhaga R, Esterly NB, Simpson JL. Prenatal diagnosis of Harlequin ichthyosis. Clin Genet. 1980;17(4):275-80.

Antonio PE, Gladys DPR. Severe ichthyosis of the newborn: An Uncommon. Pathology 2017;2:56-9.

Hassan MK, Saha AK, Begum P, Akter T, Saha SK. A case report on congenital ichthyosis – Collodion baby. Faridpur Med Coll J. 2016;11(1):00-00

Shah Farhat A, Noorizadeh Sh, Mohamadzadeh A, Saeedi R. A rare case report of a collodion baby with severe hypernatremia. Iran J Neonatol. 2017;8(2). DOI:10.22038/ijn.2017.19792.1224

Sharma D, Gupta B, Shastri S, Pandita A, Pawar S. Collodion baby with TGM I gene mutation. Internat Medical Case Rep J. 2015;8:205-8

Shareef MJ, Lawlor-Klean P, Kelly KA, LaMear NS, Schied MJ. Collodion baby: A case report. J Perinatol. 2000;4:267–9

Anjana S, Sobhanakumari K, Mathew R, Mathew R. Management of collodion baby – Our experience. J Skin Sexually Transmitted Dis. 2019;1(2):101-3

Chung M, Pittenger J, Tobin S, Chung A, Desai N. Case report expedient treatment of a collodion baby. Case Rep Dermatol Med. 2011;2011:803782. doi:10.1155/2011/803782.

Choudhary R, Sachdeva G, Katoch G, Kumar R. Collodion baby-congenital ichtyosis: Clinical review. Internat J Contemporary Pediatr. 2019;6(6):2746-9


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