Efikasi Suplementasi Asam Folat terhadap Kejadian Stroke pada Pasien Hiperhomosisteinemia dengan Riwayat Penyakit Jantung Koroner – Telaah Kasus Berbasis Bukti

Erlina Santoso, Didi Haryadi, Melva Louisa

Abstract

Beberapa studi uji klinis yang meneliti efikasi asam folat untuk mencegah kejadian stroke pada pasien hiperhomosisteinemia dengan penyakit kardiovaskular memberikan simpulan yang inkonklusif. Tujuan laporan kasus berbasis bukti ini untuk menilai apakah suplementasi asam folat dapat menurunkan risiko stroke pada pasien dengan riwayat jantung koroner dengan hiperhomosisteinemia. Pencarian komprehensif melalui beberapa basis data online. Telaah kritis menggunakan alat penilaian dari Centre of Evidence Based Medicine (CEBM). Diperoleh dua studi kajian sistematik yang sesuai kriteria seleksi. Hasil telaah kritis mendapatkan bahwa kedua studi tersebut memiliki validitas baik. Analisis menunjukkan bahwa suplementasi asam folat dapat menurunkan kejadian stroke pada pasien dengan riwayat penyakit kardiovaskular.

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References

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