Patofisiologi Spinal Cord Injury

Kartini Ciatawi, Tiffany .

Abstract

Spinal cord injury (SCI) dapat mengakibatkan defisit motorik, sensorik, dan autonom yang substansial, bahkan permanen. Saat spinal cord mengalami trauma, trauma awal akan menyebabkan kerusakan langsung; seiring waktu, proses inflamasi akut ditambah astrogliosis berkontribusi terhadap cedera sekunder. Berbagai modalitas evaluasi dan terapi SCI masih belum sepenuhnya berhasil memperbaiki fungsi neurologis. Hal ini diduga akibat
kompleksitas patofisiologi SCI.

 

Spinal cord injury (SCI) can cause substantial motor, sensory, and autonomic deficits or even permanent loss of neurological function. The initial trauma causes direct damage to the spinal cord; the acute inflammatory process coupled with astrogliosis contributes to secondary injury. Various evaluation and treatment modalities for SCI are still mostly unsuccessful in improving neurological function. This is may be due to the complexity of the pathophysiology
of SCI.

Full Text:

PDF

References

Ahuja CS, Fehlings M. Concise review: Bridging the gap: Novel neuroregenerative and neuroprotective strategies in spinal cord injury. Stem Cells Transl Med. 2016;5(7):914-24.

Gutierrez DV, Awad BI, Steinmetz MP. Pathophysiology and emergent treatment of spinal cord injury. In: Browner BD, Jupiter JB, Krettek C, Anderson P, editors. Skeletal trauma: Basic science, management, and reconstruction. 5th ed. Philadelphia: Elsevier; 2015 .p. 793-801.

Dalzell K, Nouri A, Fehlings M. The timing of management of spinal cord injuries. In: Browner BD, Jupiter JB, Krettek C, Anderson P, editors. Skeletal trauma: Basic science, management, and reconstruction. 5th ed. Philadelphia: Elsevier; 2015. p. 803-12.

Kang Y, Ding H, Zhou H, Wei Z, Liu L, Pan D, et al. Epidemiology of worldwide spinal cord injury: A literature review. J Neurorestoratol. 2017;6:1-9

Scaffolds. Katoh H, Yokota K, Fehlings MG. Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial. Front Cell Neurosci. 2019;13:248.

Anjum A, Yazid M, Fauzi Daud M, Idris J, Ng A, Selvi Naicker A, et al. Spinal cord injury: Pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Internat J Mol Sci. 2020;21(20):7533.

Couillard-Despres S, Bieler L, Vogl M. Pathophysiology of traumatic spinal cord injury. In: Weidner N, Rupp R, Tansey KE. Neurological aspects of spinal cord injury. Cham (Switzerland): Springer; 2017 .p. 503–28.

Dimitrijevic MR, Danner SM, Mayr W. Neurocontrol of movement in humans with spinal cord injury. Artif Organs. 2015;39(10):823-33.

Alizadeh A, Dyck SM, Karimi-Abdolrezaee S. Traumatic spinal cord injury: An overview of pathophysiology, models and acute injury mechanisms. Front Neurol. 2019;10:282.

Tran AP, Warren PM, Silver J. The biology of regeneration failure and success after spinal cord injury. Physiol Rev. 2018; 98(2):881-917.

Turtle JD, Henwood MK, Strain MM, Huang YJ, Miranda RC, Grau JW. Engaging pain fibers after a spinal cord injury fosters hemorrhage and expands the area of secondary injury. Exp Neurol. 2019;311:115-24.

Khanna R, Fessler R, Snyder L, Fessler R. Bradley and Daroff's neurology in clinical practice. 8th ed. Philadelphia: Elsevier; 2021..

Youmans J, Winn H. Youmans & Winn neurological surgery. 7th ed. Philadelphia: Elsevier; 2017.

Fan B, Wei Z, Yao X, Shi G, Cheng X, Zhou X, et al. Microenvironment Imbalance of spinal cord injury. Cell Transplant. 2018;27(6):853-66.

Ahuja C, Cadotte D, Fehlings M. Principles of neurological surgery. 4th ed. Philadelphia: Elsevier; 2018.

Fuller H, Gates M. Recovery of motor function following spinal cord injury. London: Intech Open; 2016.

Filous A, Schwab J. Determinants of axon growth, plasticity, and regeneration in the context of spinal cord injury. Am J Pathol. 2018;188(1):53-62.

ASIA. International Standards for Neurological Classification of SCI (ISNCSCI) Worksheet - American Spinal Injury Association [Internet]. 2021 [cited 2021 September

Available from: https://asia-spinalinjury.org/international-standards-neurological-classification-sci-isncsci-worksheet/

Eckert M, Martin M. Trauma: Spinal cord injury. Surg Clin North Am. 2017;97(5):1031-45.

Rouanet C, Reges D, Rocha E, Gagliardi V, Silva G. Traumatic spinal cord injury: Current concepts and treatment update. Arquivos de Neuro-Psiquiatria 2017;75(6):387-93.

Sánchez J, Sharif S, Costa F, Rangel J, Anania C, Zileli M. Early management of spinal cord injury: WFNS Spine Committee recommendations. Neurospine 2020;17(4):759-84.

Spinal cord injury (SCI) 2016 facts and figures at a glance. J Spinal Cord Med. 2016;39(4):493-4.

Refbacks

  • There are currently no refbacks.