Peran Citicoline Oral Sebagai Terapi Tambahan dalam Pengobatan Glaukoma
DOI:
https://doi.org/10.55175/cdk.v51i3.1051Keywords:
Citicoline, glaucoma, additional oral therapyAbstract
Glaucoma is the second-leading global cause of blindness. Lowering intraocular pressure can prevent the worsening of open-angle glaucoma, but alternative neuroprotective therapies are needed; citicoline is supposed to have neuroprotective potential. This evidence-based case report was to review the effectiveness of oral citicoline as an adjunct therapy for glaucoma. From 22 studies identified through PubMed, Scopus, Cochrane, EBSCO Host, and Google Scholar, three articles were selected for critical review. Lanza M. found the RNFL and GCC of the citicoline group 500 mg were significantly higher, 70.39 and 71.19 Pm, p<0,01 compared to controls, after 12 months. Sahin A, et al, showed that the RNFL was significantly higher in the third month than baseline in the oral citicoline 250 mg group, p = 0.038. Putri VC, et al, found that after 60 days, based on sub-group analysis, there was a significant difference in RNFL and GCIPL thickness changes after citicoline 500 mg intervention in the mild glaucoma group and after citicoline 1,000 mg in the moderate-severe glaucoma group. Oral citicoline supplementation prevents significant worsening of glaucoma, it can be given as an adjunct therapy.
Downloads
References
Malihi M, Moura Filho ER, Hodge DO, Sit AJ. Long-term trends in glaucoma-related blindness in Olmsted County, Minnesota. Ophthalmology 2014;121(1):134-41. DOI: 10.1016/j.ophtha.2013.09.003.
Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262-7. DOI: 10.1136/bjo.2005.081224.
Mahabadi N, Foris LA, Tripathy K. Open angle glaucoma [Internet]. 2023 [cited 2023 May 01]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441887/
Kementrian Kesehatan Republik Indonesia. InfoDatin: Situasi glaukoma di Indonesia. Jakarta: Pusat Data dan Informasi Kementrian Kesehatan Republik Indonesia; 2019. p.1-12.
Direktorat Jenderal Pelayanan Kesehatan. Apa itu glaukoma? [Internet]. 2022 [cited 2023 May 01]. Available from: https://yankes.kemkes.go.id/view_artikel/1059/apa-itu-glaukoma
Fogagnolo P, Rossetti L. Medical treatment of glaucoma: Present and future. Expert Opin Investig Drugs. 2011;20(7):947-59. DOI: 10.1517/13543784.2011.579901.
Baltmr A, Duggan J, Nizari S, Salt TE, Cordeiro MF. Neuroprotection in glaucoma - Is there a future role? Exp Eye Res. 2010;91(5):554-66. DOI: 10.1016/j.exer.2010.08.009.
Alvarez-Sabín J, Román GC. The role of citicoline in neuroprotection and neurorepair in ischemic stroke. Brain Sci. 2013;3(3):1395-414. DOI: 10.3390/brainsci3031395.
Secades JJ. Role of citicoline in the management of traumatic brain injury. Pharmaceuticals (Basel) 2021;14(5):410. DOI: 10.3390/ph14050410
Fresina M, Dickmann A, Salerni A, De Gregorio F, Campos EC. Effect of oral CDP-choline on visual function in young amblyopic patients. Graefes Arch Clin Exp Ophthalmol. 2008;246(1):143-50. DOI: 10.1007/s00417-007-0621-6.
Parisi V, Coppola G, Ziccardi L, Gallinaro G, Falsini B. Cytidine-5'-diphosphocholine (citicoline): A pilot study in patients with non-arteritic ischaemic optic neuropathy. Eur J Neurol. 2008;15(5):465-74. DOI: 10.1111/j.1468-1331.2008.02099.x.
Howick J, Chalmers I, Lind J, Glasziou P, Greenhalgh T, Heneghan C, et al. Oxford Centre for evidence-based medicine 2011 levels of evidence [Internet]. [cited 2023 May 01]. Available from: http://www.cebm.net/index.aspx?o=5653.
Lanza M, Gironi Carnevale UA, Mele L, Bifani Sconocchia M, Bartollino S, Costagliola C. Morphological and functional evaluation of oral citicoline therapy in chronic open-angle glaucoma patients: A pilot study with a 2-year follow-up. Front Pharmacol. 2019;10:1117. DOI: 10.3389/fphar.2019.01117.
Sahin AK, Kapti HB, Uzun A. Effect of oral citicoline therapy on retinal nerve fiber layer and ganglion cell-inner plexiform layer in patients with primary open angle glaucoma. Int J Ophthalmol. 2022;15(3):483-8. DOI: 10.18240/ijo.2022.03.17.
Putri VC, Asrory VDO. Comparison of the Effect of 1000mg and 500mg oral citicoline on visual field and ganglion cell layer thickness in primary open angle glaucoma. J Ophthalmol. 2022;7:1-10.
Parisi V, Coppola G, Centofanti M, Oddone F, Angrisani AM, Ziccardi L, et al. Evidence of the neuroprotective role of citicoline in glaucoma patients. Prog Brain Res. 2008;173:541-54. DOI: 10.1016/S0079-6123(08)01137-0.
Grieb P, Jünemann A, Rekas M, Rejdak R. Citicoline: A food beneficial for patients suffering from or threated with glaucoma. Front Aging Neurosci. 2016;8:73. DOI: 10.3389/fnagi.2016.00073.
Gandolfi S, Marchini G, Caporossi A, Scuderi G, Tomasso L, Brunoro A. Cytidine 5'-diphosphocholine (citicoline): Evidence for a neuroprotective role in glaucoma. Nutrients 2020;12(3):793. DOI: 10.3390/nu12030793.
Synoradzki K, Grieb P. Citicoline: A superior form of choline? Nutrients 2019;11(7):1569. DOI: 10.3390/nu11071569.
Patterson KY, Bhagwat SA, Williams JR, Howe JC, Holden JM. Database for the choline content of common foods [Internet]. [cited 2023 May 01]. Available from: www.ars.usda.gov/ARSUserFiles/ 80400525/Data/Choline/Choln02.pdf.
Zeisel SH, da Costa KA. Choline: An essential nutrient for public health. Nutr Rev. 2009;67(11):615-23. DOI: 10.1111/j.1753-4887.2009.00246.x.
European Food Safety Authority (EFSA). Scientific opinion on the safety of “citicoline” as a novel food ingredient. EFSA panel on dietetic products, nutrition and allergies (NDA). EFSA J [Internet]. 2013;11(10). Available from: https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2013.3421.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Wina Sinaga
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
