Aplikasi Citicoline dalam Pengobatan Stroke Hemoragik
Laporan Kasus Berbasis Bukti
DOI:
https://doi.org/10.55175/cdk.v51i4.1057Keywords:
Citicoline, stroke treatment, hemorrhagic strokeAbstract
Background: Choline-containing phospholipids, citicoline, and choline alphoscerate have been proposed as adjuvants in acute stroke treatment. An evidence-based case report (EBCR) was conducted to examine the benefits of citicoline in hemorrhagic stroke (SH) patients. Method: Search for articles published from October 2019-2023 from PubMed, Cochrane, Google Scholar, and ProQuest sources using the keywords “Citicoline”, “Hemorrhagic Stroke”, “Choline”, and “Intracerebral Hemorrhage”. The search results were evaluated using inclusion and exclusion criteria. Selected full-text studies were evaluated. The final selection results were critically reviewed based on validity, importance, and applicability by the three authors. Results: One study was considered valid, important, and applicable. The quality of this study is very high based on the literature review. Conclusion: The study shows that citicoline has the potential as an adjuvant therapy to improve clinical outcomes in SH patients, although it does not sufficiently improve neurological or functional outcomes.
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References
Unnithan AKA, M Das J, Mehta P. Hemorrhagic stroke. StatPearls [Internet]. 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559173/
Chen S, Zeng L, Hu Z. Progressing haemorrhagic stroke: Categories, causes, mechanisms and managements. J Neurol. 2014;261(11):2061-78. DOI: 10.1007/s00415-014-7291-1.
Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, et al. World stroke organization (WSO): Global stroke fact sheet 2022. Int J Stroke 2022;17(1):18–29. DOI: 10.1177/17474930211065917
Alvarez-Sabín J, Román GC. The role of citicoline in neuroprotection and neurorepair in ischemic stroke. Brain Sci. 2013;3(3):1395-414. DOI: 10.3390/brainsci3031395.
Secades JJ, Alvarez-Sabín J, Rubio F, Lozano R, Dávalos A, Castillo J; Trial Investigators. Citicoline in intracerebral haemorrhage: A double blind, randomized, placebo controlled, multi-centre pilot study. Cerebrovasc Dis. 2006;21(5-6):380-5. DOI: 10.1159/000091547.
Turana Y, Nathaniel M, Shen R, Ali S, Aparasu RR. Citicoline and COVID-19-related cognitive and other neurologic complications. Brain Sci. 2022;12:59.
Sharma A. How to write an article: An introduction to basic scientific medical writing. J Minim Access Surg. 2019;15(3):242-8. DOI: 10.4103/jmas.JMAS_91_18.
Theola J, Hermanadi MI, Gibran K, Ihsan S. Clinical outcomes of ivermectin in Covid-19 treatment: An evidence-based case report from systemic reviews and meta-analyses. J Ilmiah Mahasiswa Kedokt Indon. 2021;9(2):147-56. DOI: 10.53366/jimki.v9i2.411.
Sagaro GG, Amenta F. Choline-containing phospholipids in stroke treatment: A systematic review and meta-analysis. J Clin Med. 2023;12:2875.
Secades JJ, Gareri P. Citicoline: Pharmacological and clinical review, 2022 update. Rev Neurol. 2022;75(s05):1-89. DOI: 10.33588/rn.75s05.2022311.
Secades JJ. CDP-choline: Update and review of its pharmacology and clinical use. Methods Find Exp Clin Pharmacol. 2002;24(suppl B):1–53
Saver JL, Wilterdink J. Choline precursors in acute and subacute human stroke: A meta-analysis. Stroke 2002;33:353.
Dávalos A, Castillo J, Alvarez-Sabín J, Secades JJ, Mercadal J, Lopez S, et al. Oral citicoline in acute ischemic stroke: An individual patient data pooling analysis of clinical trials. Stroke 2002;33:2850–7.
Warach S, Harnett K. Dose dependent reduction in infarct growth with citicoline treatment: Evidence of neuroprotection in human stroke? Stroke 2002;33:354.
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