Anemia Hemolitik Autoimun pada Anak
DOI:
https://doi.org/10.55175/cdk.v46i11.403Keywords:
AIHA, autoimun, kortikosteroid, pediatrikAbstract
Anemia hemolitik autoimun (AIHA) disebabkan oleh antibodi terhadap eritrosit sendiri yang menyebabkan hemolisis dan anemia. Penyebab yang paling sering idiopatik. Pada anak, biasanya bersifat akut dan dapat mengancam jiwa. Terapi lini pertama AIHA adalah kortikosteroid dan imunoglobulin. Respons paling baik terhadap steroid didapatkan pada anak.
Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies against own erythrocytes leading to hemolysis and anemia. The most common cause is idiopathic. In children, this anemia is usually acute and can be life-threatening. First line therapy is corticosteroid and can be combined with intravenous immunoglobulin. Best response to steroids is among children.
Downloads
References
Fan J, He H, Zhao W, Wang Y, Lu J,Li J, et al. Clinical features and treatment outcomes of childhood autoimmune hemolytic anemia: A restrospective analysis of 68 cases. J Pediatr Hematol Oncol. 2016; 38(2):50-5.
Bass GF, Tuscano ET, Tuscano JM. Diagnosis and classification of autoimmune hemolytic anemia. Elsevier. 2014; 13(14):560-4.
Sarper N, Kilic SC, Zengin E, Gelen SA. Management of autoimmune hemolytic anemia in children and adolescents: A single center experience. Turk J Hematol. 2011;28:198-205.
Ladogana S, Maruzzi M, Russo G. Diagnosis and management of newly diagnosed childhood autoimmune haemolytic anaemia. Blood Transfus. 2017; 15(3): 259–67.
Berentsen S, Sundic T. Red blood cell destruction in autoimmune hemolytic anemia: Role of complement and potential new targets for therapy. BioMed Research International. 2015;2015:1-11.
Zanella A, Barcellini W. Treatment of autoimmune hemolytic anemias. Haematologica. 2014; 99(10): 1437-554.
Flores G, Cunningham-Rundles C, Newland AC, Bussel JB. Efficacy of intravenous immunoglobulin in the treatment of autoimmune haemolytic anemia: Results in 73 patients. American Journal of Haematology. 1993;44: 237-42.
Zeerleder S. Autoimmune haemolytic anaemia- a practical guide to cope wit a diagnostic and therapeutic challenge. The journal of medicine. 2011; 69(4): 177-84.
Zecca M, Nobili B, Ramenghi U, Perrotta S, Amendola G, Rsito P, et al. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood.2003;101(10):3857-61.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.