Diagnosis dan Tatalaksana Enterokolitis Nekrotikans
DOI:
https://doi.org/10.55175/cdk.v48i4.62Keywords:
Enterokolitis nekrotikans, neonatus prematurAbstract
Enterokolitis nekrotikans (EKN) ialah peradangan berat saluran pencernaan yang terjadi pada 5-7% neonatus prematur. EKN merupakan penyebab utama morbiditas dan mortalitas di NICU. Patofisiologi multifaktorial dan belum sepenuhnya diketahui. Deteksi dini sulit karena manifestasi klinis sulit dibedakan dan masih tergantung pada radiologi abdomen yang kurang sensitif. Patofisiologi dan pendekatan diagnosis menjadi topik penelitian prioritas di bidang neonatologi saat ini. Strategi pencegahan dan tatalaksana komprehensif diharapkan dapat ditemukan agar memperbaiki luaran penyakit.
Necrotizing enterocolitis (NEC) is a serious inflammatory disease of intestine which affects 5-7% preterm neonates. NEC is the leading cause of morbidity and mortality in NICU despite rapid advance in preterm neonatal care. Pathophysiology of NEC is multifactorial and not fully understood. Early detection is challenging because of indistinguishable clinical manifestation and still relies on less sensitive abdominal radiography. Nowadays, pathophysiology and diagnostic approach are priority topics for research in neonatology. Comprehensive prevention and treatment strategies expectedly can improve outcome of disease
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References
De Curtis M, Terrin G. Necrotizing enterocolitis (NEC): What’s going on. J Pediatr Neonat Individual Med. 2013;2(2):e020218. doi: 10.7363/020218.
Alganabi M, Lee C, Bindi E, Li B, Pierro A. Recent advances in understanding necrotizing enterocolitis. F1000 Res. 2019;8:1-9.
Neu J, Walker W. Necrotizing enterocolitis. N Engl J Med. 2011;364(3):255-64.
Haque K. Necrotizing enterocolitis - Some things old and some things new: A comprehensive review. J Clin Neonatol. 2016;5(2):79.
Bazacliu C, Neu J. Necrotizing enterocolitis: Long term complications. Curr Pediatr Rev. 2019;15(2):115-24.
Neu J. Necrotizing enterocolitis: The future. Neonatology. 2020;117:240–24 doi:10.1159/000506866.
Neu J. Necrotizing enterocolitis: The mystery goes on. Neonatology. 2014;106(4):289-95.
Neu J, Modi N, Caplan M. Necrotizing enterocolitis comes in different forms: Historical perspectives and defining the disease. Semin Fetal Neonatal Med. 2018;23(6):370-3.
Wertheimer F, Arcinue R, Niklas V. Necrotizing enterocolitis: Enhancing awareness for the general practitioner. Pediatrics in Review. 2019;40(10):517-27.
Hackam DJ, Sodhi CP: Toll-like receptor-mediated intestinal inflammatory imbalance in the pathogenesis of necrotizing enterocolitis. Cell Mol Gastroenterol Hepatol. 2018;6(2): 229–38.e1.
Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018;27(1):57–64.
Pammi M, Cope J, Tarr PI, Warner BB, Morrrow AL, Mai V, et al. Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: A systematic review and meta-analysis. Microbiome. 2017;5(1): 31.
Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, et al. Mucosa-associated bacterial diversity in necrotizing enterocolitis. PLoS ONE. 2014;9(9):e105046.https://doi.org/10.1371/journal.pone.0105046
Wang Y, Hoenig JD, Malin KJ, Qamar S, Petrof EO, Sun J, et al. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. ISME J. 2009;3(8):944-54. doi:10.1038/ismej.2009.37
Rose AT, Patel RM. A critical analysis of risk factors for necrotizing enterocolitis. Semin Fetal Neonatal Med. 2018;23(6):374–9.
Soni R, Katana A, Curry J, Humphries P, Huertas-Ceballos A. How to use abdominal X-rays in preterm infants suspected of developing necrotising enterocolitis. Arch Dis Childhood - education & practice ed. 2019;:edpract-2018-315252.
Kim J. Role of abdominal US in diagnosis of NEC. Clin Perinatol. 2019;46(1):119-27.
Feuille E, Nowak-Węgrzyn A. Definition, etiology, and diagnosis of food protein-induced enterocolitis syndrome. Curr Op Allerg Clin Immunol. 2014;14(3):222-8.
Thakkar H, Lakhoo K. Necrotizing enterocolitis. Surgery (Oxford). 2019;37(11):628-31.
Adams-Chapman I. Necrotizing enterocolitis and neurodevelopmental outcome. Clin Perinatol. 2018;45(3):45366. doi:10.1016/j.clp.2018.05.014.
Bode L. Human milk oligosaccharides in the prevention of necrotizing enterocolitis: A journey from in vitro and in vivo models to mother-infant cohort studies. Front Pediatr. 2018;6:385. doi:10.3389/fped.2018.00385.
Ou J, Courtney CM, Steinberger AE, Tecos ME, Warner BW. Nutrition in necrotizing enterocolitis and following intestinal resection. Nutrients 2020;12(2):520.
Jin Y, Duan Y, Deng X, Lin J. Prevention of necrotizing enterocolitis in premature infants – an updated review. World J Clin Pediatr. 2019;8(2):23-32.
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