Vitamin D dan COVID-19: Tinjauan Literatur
DOI:
https://doi.org/10.55175/cdk.v49i2.199Keywords:
sistem imun, COVID-19, vitamin DAbstract
Pendahuluan: Penyakit coronavirus (COVID-19) merupakan penyakit infeksi yang dideklarasikan WHO sebagai kasus gawat darurat kesehatan di dunia. Vitamin D diketahui memegang peranan dalam regulasi sistem imun baik pada penyakit infeksi maupun penyakit autoimun, sehingga vitamin D dapat bermanfaat pada tata laksana COVID-19. Metode: Tinjauan literatur COVID-19 dan kaitannya dengan vitamin D; sumber data dari Google Cendekia, PubMed, dan WHO. Hasil: Vitamin D berperan mengendalikan sistem sel imun seperti makrofag, limfosit, neutrofil, dan sel dendritik. Selain itu, mekanisme kerja innate dan adaptive immune system diperantarai oleh vitamin D, menghasilkan keseimbangan respons imun untuk meningkatkan respons anti-inflamasi. Simpulan: Vitamin D berkaitan dengan infeksi COVID-19 (dapat mengurangi risiko infeksi, mencegah perkembangan infeksi, dapat menurunkan tingkat keparahan, dan meringankan komplikasi badai sitokin; dengan demikian, dapat menurunkan morbiditas dan mortalitas akibat infeksi COVID-19.
Introduction: Coronavirus disease (COVID-19) is an infectious disease declared by WHO as a worldwide pandemic. Vitamin D supplementation is known to play a key role in regulating the immune system both in infectious and autoimmune diseases; it is believed to correlate with COVID-19. Method: A review of COVID-19 and their correlation with vitamin D, from the published data in Google Scholar, PubMed, and WHO. Result: Vitamin D play a role in the immune cell systems. It also regulates the innate immune system and adaptive immune system in response to increased anti-inflammatory response. Conclusion: Vitamin D can reduce the risk, prevent the development, and reduce the severity of infection and the effect of cytokines storm. Supplementation of vitamin D may reduce the morbidity and mortality of COVID-19.
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