Diagnosis dan Tata Laksana Sindrom Tolosa Hunt


  • Amelia Puspita Suhendro RSUD Badung, Bali, Indonesia




Nyeri periorbital, oftalmoplegia, sindrom Tolosa Hunt


Sindrom Tolosa Hunt adalah nyeri periorbital atau orbital unilateral serta paresis satu atau lebih saraf kranial III, IV, dan/atau VI, yang disebabkan oleh peradangan sinus kavernosus, fisura orbital superior, dan rongga orbital. Gejala berkurang dalam 72 jam setelah terapi corticosteroid yang adekuat. Diagnosis yang tepat memungkinkan intervensi segera, dengan demikian dapat mencegah keparahan termasuk kehilangan penglihatan.

Tolosa Hunt syndrome is unilateral periorbital or orbital pain and paresis of one or more cranial nerves III, IV, and/or VI caused by inflammation of the cavernous sinus, superior orbital fissure, and orbital cavity. Symptoms will relieve within 72 hours after adequate corticosteroid therapy. Appropriate diagnosis of the disease can allow for immediate intervention and thus prevent severity including loss of vision.


Download data is not yet available.


im H, Oh SY. The clinical features and outcomes of Tolosa-Hunt syndrome. BMC Ophthalmology 2021;21:1-5.

Colnaghi S, Versino M, Marchioni E, Pichiecchio A, Bastianello S, Cosi V, et al. ICHD-II diagnostic criteria for Tolosa—Hunt syndrome in idiopathic inflammatory syndromes of the orbit and/or the cavernous sinus. Cephalalgia 2008;28(6):577-84.

Headache classification committee of the international headache society (IHS) the International Classification of Headache Disorders. Cephalalgia 2018;38(1):177.

Mantia LL, Curone M, Rapoport AM, Bussone G. Tolosa–Hunt syndrome: Critical literature review based on IHS 2004 criteria. Cephalalgia 2006;26(7):772-81.

Corredor MM, Holmberg PJ. Ophthalmoplegia and cranial nerve deficits in an adolescent with headache. SAGE Open Medical Case Reports 2021;01:9.

Zhang X, Zhou Z, Steiner TJ, Zhang W, Liu R, Dong Z, et al. Validation of ICHD-3 beta diagnostic criteria for 13.7 Tolosa-Hunt syndrome: Analysis of 77 cases of painful ophthalmoplegia. Cephalalgia 2014;34(8):624-32.

Bugeme M, Cissé O, Mukuku O, Amadou GD. Tolosa–Hunt syndrome: A painful ophthalmoplegia. Case Reports in Neurological Medicine 2020;2020:8883983.

Olsen K, Johnson A, Castillo-Jorge S, Bennett J, Ryan MF. Diagnosis and treatment of Tolosa-Hunt syndrome in the emergency department. Open J Emergency Med. 2017;5(1):1-7.

Akpinar ÇK, Özbenli T, Doğru H, Incesu L. Tolosa-Hunt syndrome - Cranial neuroimaging findings. Noro-Psikyatri Arsivi 2017;54(3):251-4.

Wada T, Shima A, Kuzuya A, Maki T, Yamashita H, Takahashi R. Dynamic alteration of internal carotid artery related to granuloma in a case of Tolosa–Hunt syndrome. Acta Neurol Belgica. 2021:1-3.

Chen H, Wang X, Yao S, Raza HK, Jing J, Cui G, et al. The aetiologies of unilateral oculomotor nerve palsy: A clinical analysis on 121 patients. Somatosensory Motor Res. 2019;36(2):102-8.

Sowmini PR, Velayutham SS, Jeyaraj MK, Kumar MS, Saravanan SV, Mugundhan K. Remarkable benefit of infliximab therapy in recurrent Tolosa Hunt syndrome. Neurology India 2022;70(3):1289.

Ayat A, Elziny MM, Mansour E. A case report on a unique explanation for headache with ophthalmoplegia: The Tolosa-Hunt syndrome. Cureus 2022;14 (6):e26093. doi:10.7759/cureus.26093

Wasmeier C, Pfadenhauer K, Rösler A. Idiopathic inflammatory pseudotumor of the orbit and Tolosa-Hunt syndrome - are they the same disease. J Neurol. 2002;249(9):1237-4.

Arshad A, Nabi S, Panhwar MS, Rahil A. Tolosa-Hunt syndrome: An arcane pathology of cavernous venous sinus. BMJ Case Reports. 2015;2015:bcr2015210646. doi: 10.1136/bcr-2015-210646.




How to Cite

Suhendro, A. P. (2023). Diagnosis dan Tata Laksana Sindrom Tolosa Hunt. Cermin Dunia Kedokteran, 50(9), 486–489. https://doi.org/10.55175/cdk.v50i9.1034