Amoxicillin versus Cotrimoxazole for Treating Non-severe Pneumonia: A Systematic Review
DOI:
https://doi.org/10.55175/cdk.v51i8.1225Keywords:
Amoxicillin, children under 5 years old, cotrimoxazole, pneumonia, systematic review, treatment failureAbstract
Introduction: Pneumonia is still one of the common causes of death in children under 5 years old in low-middle-income countries. The common cause of pneumonia is bacteria, requiring antibiotics as treatment. This systematic review evaluates the efficacy of amoxicillin and cotrimoxazole in treating pneumonia. Methods: This systematic review used PRISMA rules to analyze Pubmed and Europe PMC articles. The dose, duration, and therapeutic failure of amoxicillin and cotrimoxazole were assessed. Results: A total of 336 articles were selected for title and abstract screening. Four articles met the requirements, and two were selected for systematic review analysis. A total of 20,646 patients were analyzed, 11,633 (56.3%) received amoxicillin and 9,013 (43.7%) received cotrimoxazole. There was no significant difference in treatment failure between amoxicillin and cotrimoxazole. Conclusion: Amoxicillin has the same efficacy as cotrimoxazole for the management of non-severe pneumonia in children under 5 years old.
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References
UNICEF. A child dies of pneumonia every 43 seconds [Internet]. 2023 [cited 2024 Feb 20]. Available from: https://data.unicef.org/topic/child-health/pneumonia/.
Kemenkes RI. Laporan nasional Riskesdas 2018. Lembaga Penelitian dan Pengembangan Kesehatan (LPB): Indonesia; 2019.
Kemenkes RI. Profil kesehatan Indonesia 2022. Kemenkes RI: Jakarta; 2023.
Ciptaningtyas VR, De Mast Q, De Jonge MI. The burden and etiology of lower respiratory tract infections in children under five years of age in Indonesia. J Infect Dev Ctries 2021;15(5):603–14. DOI: 10.3855/jidc.14268.
Meyer Sauteur P. Childhood community-acquired pneumonia. European Journal of Pediatrics 2024;183:1129-36. DOI: 10.1007/s00431-023-05366-6.
Kuitunen I, Jaaskelainen J, Korppi M, Renko M. Antibiotic treatment duration for community-acquired pneumonia in outpatient children in high-income countries—A systematic review and meta-analysis. Clinical Infectious Diseases 2023;76(3):e1123-28. DOI: 10.1093/cid/ciac374.
Wahyudi N, Winardi W, Karyono Y, Nugroho A, Sofyan A, Budiati I, et al. Statistik Indonesia 2023. Badan Pusat Statistik: Jakarta; 2024.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372(71):1–9. DOI: 10.1136/bmj.n71.
Sadruddin S, Khan IUH, Fox MP, Bari A, Khan A, Thea DM, et al. Comparison of 3 days amoxicillin versus 5 days cotrimoxazole for treatment of fast-breathing pneumonia by community health workers in children aged 2-59 months in Pakistan: A cluster-randomized trial. Clin Infect Dis.2019;69(3):397–404. DOI: 10.1093/cid/ciy918.
Zar H, Moore DP, Andronikou S, Argent AC, Avenant T, Cohen C, et al. Diagnosis and management of community-acquired pneumonia in children: South African Thoracic Society guidelines. African Journal of Thoracic and Critical Care Medicine 2020;26(3):98–116. DOI: 10.7196/AJTCCM.2020.v26i3.104.
Smith DK, Kuckel DP, Recidoro AM. Community-acquired pneumonia in children: Rapid evidence review. Am Fam Physician 2021;104(6).
Ahmed S, Ariff S, Muhammed S, Rizvi A, Ahmed I, Soofi SB, et al. Community case management of fast-breathing pneumonia with 3 days oral amoxicillin vs 5 days cotrimoxazole in children 2-59 months of age in rural Pakistan: A cluster randomized trial. J Glob Health 2022;12:04097. DOI: 7189/jogh.12.04097.
Tramper-Stranders GA. Childhood community-acquired pneumonia: A review of etiology- and antimicrobial treatment studies. Paediatr Respir Rev. 2018;26:41–8. DOI: 10.1016/j.prrv.2017.06.013.
Benet T, Sylla M, Messaoudi M, Picot VS, Telles JN, Diakite AA, et al. Etiology and factors associated with pneumonia in children under 5 years of age in Mali: A prospective case-control study. PLoS One 2015;10(12):1–15. DOI: 10.1371/journal.pone.0145447.
Kamianowska M, Kamianowska A, Wasilewska A. Causes of death in neonates, infants, children, and adolescents at the University Children’s Clinical Hospital of Białystok between 2018 and 2021. Medical Science Monitor 2023;29:1–9. DOI: 10.12659/MSM.939915.
Khan R, Bakry M, Islahudin F. Appropriate antibiotic administration in critically ill patients with pneumonia. Indian J Pharm Sci 2015;77(3):299–305. DOI: 10.4103/0250-474x.159623.
Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, et al. Short-course vs long-course antibiotic therapy for children with nonsevere community-acquired pneumonia. JAMA Pediatr 2022;176(12):1199–207. DOI: 10.1001/jamapediatrics.2022.4123.
Efendy SA, Ismunandar A, Maulana LH. Monitoring efek samping amoxicillin dan cotrimoxazole pada pasien anak di Puskesmas Paguyangan tahun 2022. Pharmacy Peradaban Journal 2023;3(1):12–21.
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