Effectiveness of Influenza Vaccine on the Risk of Pneumonia Complications in Children
Analysis
DOI:
https://doi.org/10.55175/cdk.v52i6.1691Keywords:
Children, pneumonia, influenza, influenza vaccineAbstract
Influenza is an acute respiratory infection (ARI) caused by the influenza virus. World Health Organization (WHO) states that influenza virus infection causes 99% deaths in children under 5 years of age in developing countries. Transmission between individuals is fast because the influenza virus is transmitted through droplets. Symptoms of influenza disease vary; most are mild and self-limiting, but in some cases, it can cause severe complications and have an impact on mortality. Pneumonia is one of the most common complications of influenza, especially in the pediatric population. Influenza vaccination is an effective option for preventing infection and its complications. Several studies have shown that influenza vaccination can reduce influenza cases and the incidence of influenza-related pneumonia hospitalizations.
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References
WHO. Influenza (seasonal) dashboard [Internet]. 2014 [cited 2024 Jul 23]. Available from: https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).
Survei Kesehatan Indonesia. Laporan SKI 2023. Jakarta: Kemenkes; 2023.
Mameli C, Cocchi I, Fumagalli M, Zuccotti G. Influenza vaccination: Effectiveness, indications, and limits in the pediatric population. Front Pediatr. 2019;7:317. DOI:10.3389/fped.2019.00317.
Fauzi IS, Wardani IB, Nuraini N. Epidemiological modeling of influenza-like illness (ILI) transmission in Jakarta, Indonesia through cumulative generating operator on SLIR model. Biosafety Biosecurity 2023;5(4):135-45. DOI:10.1016/j.jobb.2023.10.001.
Wang Q, Yuan L, Lin J, Zhuo Z, Wang Y, Li S, et al. Clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children: A retrospective analysis. BMC Infect Dis. 2023;23(1):545. DOI:10.1186/s12879-023-08536-x.
World Health Organization (WHO). Surveillance case definitions for ILI and SARI [Internet]. 2014 [cited on 2021 Jul 30]. Available from: https://www.who.int/teams/global-influenza-programme/surveillance-and-monitoring/case-definitions-for-ili-and-sari.
Wignjadiputro I, Susilarini NK, Setiawaty V, Mahkota R. Influenza related pneumonia in children under five years old in Indonesia: An analysis of the risk factors. Riset Informasi Kesehatan 2019;7(2):107. DOI:10.30644/rik.v7i2.119.
Rizzo C, Rezza G, Ricciardi W. Strategies in recommending influenza vaccination in Europe and US. Hum Vaccin Immunother. 2018;14(3):693–98. DOI:10.1080/21645515.2017.1367463.
Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-associated respiratory mortality: A modelling study. Lancet 2018;391(10127):1285-300. DOI:10.1016/S0140-6736(17)33293-2.
Cavallazzi R, Ramirez JA. Influenza and viral pneumonia. Clin Chest Med. 2018;39(4):703-21. DOI: 10.1016/j.ccm.2018.07.005.
Shrestha S, Foxman B, Berus J, van Panhuis W, Steiner C, Viboud C, et al. The role of influenza in the epidemiology of pneumonia. Sci Rep. 2015;5:15314. DOI: 10.1038/srep15314.
Moghadami M. A narrative review of influenza: A seasonal and pandemic disease. Iran J Med Sci. 2017;42(1):2-13. PMID: 28293045.
Ishiguro T, Kagiyama N, Uozumi R, Odashima K, Takaku Y, Kurashima K, et al. Clinical characteristics of influenza-associated pneumonia of adults: Clinical features and factors contributing to severity and mortality. Yale J Biol Med. 2017;90(2):165-81. PMID: 28656006.
Kliegman RM, St Geme III JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, et al. Nelson Textbook of Pediatrics. 21st Ed. Canada: Elsevier; 2019.
Poon LL, Song T, Rosenfeld R, Lin X, Rogers MB, Zhou B, et al. Quantifying influenza virus diversity and transmission in humans. Nat Genet. 2016;48(2):195–200. DOI: 10.1038/ng.3479.
van der Sluijs KF, van der Poll T, Lutter R, Juffermans NP, Schultz MJ. Bench-to-bedside review: Bacterial pneumonia with influenza - Pathogenesis and clinical implications. Crit Care 2010;14(2):219. DOI: 10.1186/cc8893.
Fallon EA, Boring MA, Foster AL, Stowe EW, Lites TD, Odom EL, et al. High incidence of influenza and disease severity among children and adolescents aged <18 Years ― United States, 2022–23 Season. MMWR Morb Mortal Wkly Rep. 2023;72(41):1104-14. DOI: http://dx.doi.org/10.15585/mmwr.mm7241a2.
Dananche C, Picot VS, Benet T, Messaoudi M, Chou M, Wang J, et al. Burden of influenza in less than 5-year-old children admitted to hospital with pneumonia in developing and emerging countries: A descriptive, multicenter study. Am J Trop Med Hyg. 2018;98(6):1805–10. DOI: 10.4269/ajtmh.17-0494.
Kondrich J, Rosenthal M. Influenza in children. Curr Opin Pediatr. 2017;29(3):297–302. DOI: 10.1097/MOP.0000000000000495.
Qin Q, Xie ZD, Shen KL. Interpretation of the 2018 guidelines for diagnosis, treatment, chemoprophylaxis and institutional outbreak management of seasonal influenza for children, updated by the Infectious Diseases Society of America. Chin J Appl Clin Pediatr. 2019;34(2):87–90.
Respiratory Group of Pediatric Branch of Chinese Medical Association. Editorial Board of Chinese Journal of Practical Pediatrics. Expert consensus on diagnosis and treatment of influenza in children (2015). Chin J Appl. Clin Pediatr. 2015;30(17):1296–303. DOI: 10.1007/s12519-023-00777-9.
Bakaletz LO. Viral-bacterial co-infections in the respiratory tract. Curr Opin Microbiol. 2017;35:30–5. DOI: 10.1016/j.mib.2016.11.003.
Xu J, Yu J, Yang L, Zhou F, Li H, Cao B. Influenza virus in community-acquired pneumonia: Current understanding and knowledge gaps. Semin Respir Crit Care Med. 2020;41(4):555–67. DOI: 10.1055/s-0040-1710584.
Fang C, Chen XJ, Zhou MM, Chen YH, Zhao RZ, Deng JK, et al. Clinical characteristics and antimicrobial resistance of pneumococcal infections from 9 children’s hospitals in 2016. Chin J Pediatr. 2018;56(08):582–6. DOI: 10.3760/cma.j.issn.0578-1310.2018.08.005.
Nayak J, Hoy G, Gordon A. Influenza in children. Cold Spring Harb Perspect Med. 2021;11(1):a038430. DOI: 10.1101/cshperspect.a038430.
De Schutter I, De Wachter E, Crokaert F, Verhaegen J, Soetens O, Pierard D, et al. Microbiology of bronchoalveolar lavage fluid in children with acute nonresponding or recurrent community-acquired pneumonia: Identification of nontypeable Haemophilus influenzae as a major pathogen. Clin Infect Dis. 2011; 52(12):1437-44. DOI: 10.1093/cid/cir235.
Bugin S, Lunardi F, Bertuola F, Snijders D, Bottecchia L, Perissinotto E, et al. Pediatric chronic lower respiratory disorders: Microbiological and immunological phenotype. Pediatr Pulmonol. 2013; 48(8):780-8. DOI: 10.1002/ppul.22677.
Newall AT, Nazareno AL, Muscatello DJ, Boettiger D, Viboud C, Simonsen L, et al. The association between influenza vaccination uptake and influenza and pneumonia-associated deaths in the United States. Vaccine 2024;42(8):2044-50. DOI: 10.1016/j.vaccine.2024.01.089.
Trombetta CM, Kistner O, Montomoli E, Viviani S, Marchi S. Influenza viruses and vaccines: The role of vaccine effectiveness studies for evaluation of the benefits of influenza vaccines. Vaccines (Basel). 2022;10(5):714. DOI: 10.3390/vaccines10050714.
Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2024-2025: Policy statement. Pediatrics 2024;154(4): e2024068507. DOI: 10.1542/peds.2024-068507.
Centers For Disease Control and Prevention. Benefits of the flu vaccine [Internet]. 2024. Available from: https://www.cdc.gov/flu-vaccines-work/benefits/index.html.
AAP Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2023-2024. Pediatrics 2023;152(4):e2023063772. DOI:10.1542/peds.2023-063772.
Soedjatmiko S, Medise BE, Gunardi H, Sekartini R, Satari HI, Hadinegoro SR, et al. Immunogenicity and safety of a trivalent influenza HA vaccine in Indonesian infants and children. Vaccine 2018;36(16):2126-32. DOI:10.1016/j.vaccine.2018.02.114.
Tessmer A, Welte T, Schmidt-Ott R, Eberle S, Barten G, Suttorp N, et al. Influenza vaccination is associated with reduced severity of community-acquired pneumonia. Eur Respir J. 2011;38(1):147-53. DOI:10.1183/09031936.00133510.
Sadnyani DA, Wiraningrat GA, Windiyanto R. Efektivitas vaksin influenza terhadap kejadian rawat inap pada anak dengan influenza: Sebuah tinjauan sistematik dan meta analisis. Intisari Sains Medis. 2022;13(3):590-8. DOI: 10.15562/ism.v13i3.
Olson SM, Newhams MM, Halasa NB, Feldstein LR, Novak T, Weiss S, et al. Vaccine effectiveness against life-threatening influenza illness in US children. Clin Infect Dis. 2022;75(2):230-8. DOI: 10.1093/cid/ciab931.
Centers for Disease Control and Prevention. Influenza vaccination: A summary for clinicians [Internet]. 2023 [cited on 2024 Aug 1]. Available from: https://www.cdc.gov/flu/professionals/vaccination/vax-summary.htm.
Sitaresmi NM, Soedjatmiko, Gunardi H, Kaswandani N, Handryastuti S, Raihan, et al. Jadwal imunisasi anak usia 0-18 tahun (rekomendasi Ikatan Dokter Anak Indonesia tahun 2023). Sari Pediatri 2023;25(1):64-74.
Kementerian Kesehatan Republik Indonesia. Kemenkes tambah 3 jenis vaksin imunisasi rutin [Internet]. 2022 [cited 2024 Aug 2]. Available from: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20220423/2939708/39708/.
Malik YA. Impact of influenza in South-East Asia. Internati J Infect Dis. 2023;130(2):S40-1. DOI: 10.1016/j.ijid.2023.04.095.
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