Anosmia pada COVID-19
DOI:
https://doi.org/10.55175/cdk.v48i1.30Keywords:
Anosmia, COVID-19, gangguan penghiduAbstract
Sejak tanggal 11 Maret 2020, WHO telah mendeklarasikan COVID-19 sebagai pandemi. Gejala COVID-19 yang paling umum adalah demam, malaise, dan batuk kering, namun dapat juga muncul gejala gangguan penghidu atau anosmia. Anosmia pada COVID-19 dapat disebabkan oleh invasi langsung oleh virus melalui epitel hidung dan bulbus olfaktorius pada reseptor ACE2. Anosmia pada COVID-19 ini dapat timbul tiba-tiba atau didahului oleh gejala ringan seperti batuk kering. Tatalaksana anosmia pada COVID-19 masih terus berkembang dan diteliti lebih lanjut.
Since March 11, 2020, WHO has declared COVID-19 a pandemic. The most common symptoms of COVID-19 are fever, malaise, and dry cough, but there can also be symptoms of olfactory dysfunctions including anosmia. Anosmia in COVID-19 can be caused by direct viral invasion through the nasal epithelium and olfactory bulb at the ACE2 receptor. Anosmia in COVID-19 can spontaneously appear or preceded by mild symptoms such as dry cough. The management of anosmia in COVID-19 is still developing and needs more in-depth research.
Downloads
References
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382:1199–207. doi: 10.1056/NEJMoa2001316
Who.int. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020 [Internet]. 2020. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020
Covid19.who.int. WHO coronavirus disease (COVID-19) dashboard [Internet]. 2020. Available from: https://covid19.who.int/4. Who.int. Coronavirus [Internet]. 2020. Available from: https://www.who.int/health-topics/coronavirus#tab=tab_3
Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and anosmia: A review based on up-to-date knowledge. Am J Otolaryngol. 2020;41(5):102581.
Kemenkes RI. Pedoman pencegahan dan pengendalian coronavirus disease (COVID-19). Germas. 2020.
Handayani D, Hadi DR, Isbaniah F, Burhan E, Agustin H. Corona virus disease 2019. J Respirol Indon. 2020;40(2):119-29.
World Health Organization. Coronavirus disease (COVID-19): Weekly epidemiological update [Internet]. 2020. Available from: https://www.who.int/
Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, et al. COVID-19 and the chemical senses: Supporting players take center stage. Neuron. 2020;107(2):219–33.
Baig AM. Neurological manifestations in COVID19 caused by SARSCoV 2. CNS neuroscience & therapeutics. 2020;26(5):499.
Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: A review. JAMA Neurol. 2020;77(8):1018-24.
Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177-9.
Colavita F, Lapa D, Carletti F, Lalle E, Bordi L, Marsella P, et al. SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. Ann Intern Med. 2020:M20-1176.
Heidari F, Karimi E, Firouzifar M, Khamushian P, Ansari R, Ardehali MM, et al. Anosmia as a prominent symptom of COVID-19 infection. Rhinology. 2020;58(3):302-3.
Eliezer M, Hautefort C, Hamel AL, Verillaud B, Herman P, Houdart E, et al. Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol. 2020;146(7):674-5.
Klopfenstein T, Toko L, Royer PY, Lepiller Q, Gendrin V, Zayet S. Features of anosmia in COVID-19. Médecine et Maladies infectieuses. 2020;50(5):436-9.
Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, et al. Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19–positive patients compared to subjective methods: A systematic review and meta-analysis [Internet]. 2020 Oct 20. Available from https://academic.oup.com/chemse/advance-article/doi/10.1093/chemse/bjaa064/5912953
Whitcroft KL, Hummel T. Olfactory dysfunction in COVID-19: Diagnosis and management. JAMA. 2020;323(24):2512-4
Harless L, Liang J. Pharmacologic treatment for postviral olfactory dysfunction: A systematic review. Internat Forum Allerg Rhinol. 2016;6(7):760-7
Soler ZM, Patel ZM, Turner JH, Holbrook EH. A primer on viral‐associated olfactory loss in the era of COVID‐19. Internat Forum Allerg Rhinol 2020;10(7):814-20.
Altundag A, Cayonu M, Kayabasoglu G, Salihoglu M, Tekeli H, Saglam O, et al. Modified olfactory training in patients with postinfectious olfactory loss. Laryngoscope.2015;125(8):1763-6.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Cermin Dunia Kedokteran
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.