Analisis Gas Darah dan Laktat Darah Tali Pusat sebagai Parameter Metabolik pada Asfiksia Perinatal
DOI:
https://doi.org/10.55175/cdk.v46i9.450Keywords:
Laktat, Asfiksia perinatalAbstract
Asfiksia masih merupakan salah satu penyebab utama kematian neonatus per tahun. Skor Apgar dapat memberikan informasi vitalitas neonatus namun memiliki beberapa keterbatasan. Asfiksia perinatal dapat muncul dari berbagai risiko intrapartum dan postpartum yang mengakibatkan terhentinya pertukaran gas pada fetus. Metabolisme anaerob akan menyebabkan akumulasi laktat dan penurunan pH. Analisis asam-basa dan laktat darah tali pusat dapat memberikan penilaian objektif terhadap status metabolik neonatus.
Asphyxia still remain a major causes of neonatal death per year. Apgar score provides information on neonatal vitality but has several limitations. Perinatal asphyxia can arise from a variety of intrapartum and postpartum risks which result in cessation of gas exchange. Anaerobic metabolism will cause lactate accumulation and pH decrease. Analysis of acid-base and lactate in cord blood can provide an objective assessment of the metabolic status of the neonate.
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References
Denihan NM, Boylan GB, Murray DM. Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field. Biomed Res Int.2015:1-7
Larosa DA, Ellery SJ, Walker DW, Dickinson H. Understanding the Full Spectrum of Organ injury Following intrapartum Asphyxia. Front Pediatr. 2017:1-7
Butruille L, Jonckheene JD, Flocteil M et al. Parasympathetic tone variations according to umbilical cord pH at birth: a computerized fetal heart rate variability analysis.J Clin Monit Comput. 2016:1-4.
Allanson ER, Pattinson RC, Nathan EA, Dickinson JE. The introduction of umbilical cord lactate measurement and associated neonatal ourcomes in a South African tertiary hospital labor ward. J Matern-Fetal Neo M. 2017;1-6.
Morton SU, Brodsky D. Fetal Physiology and the Transition to Extrauterine Life. Clin Perinatol. 2016: 1-11.
Reinke SN, Walsh BH, Boylan GB, Sykes BD, Kenny LC, Murray DM, et al. 1H NMR Derived Metabolomic Profile of Neonatal Asphyxia in Umbilical Cord Serum: Implications for Hypoxic Ischemic Encephalopathy. J. Proteome Res. 2013(12):4230−9
Rainaldi MA, Perlman JM. Pathophysiology of birth asphyxia. Article in Press. Clin Perinatol.2016:1-11
Antonucci R, Porcella A, Pilloni MD. Perinatal asphyxia in the term newborn. J Pediatr Neonat Individual Med. 2014;3(2):1-11
Almeida MFB, Moreira LMO, Santos RMV, Kawasaki MD, Anchietta LM, Guinsburg R. Early neonatal deaths with perinatal asphyxia in very low birth weight Brazilian infants. J. Perinatol. 2015:1–4
Cuevas IT, Llorca AP, Illana AS, Ramiro AN, Kuligowski J, Pericas CC et al. Oxygen and oxidative stress in the perinatal period. Redox Biol.2017;(12): 674-81
Roebiono PS, Rahajoe AU, Sastroasmoro S. Embriogenesis Kardiovaskular dan Sirkulasi Janin. Dalam: Sastroasmoro S, Madiyono B, penyunting. Buku Ajar Kardiologi Anak. Jakarta; BP IDAI. 2014:165-72
Yli BM, Kjellmer I. Pathophysiology of foetal oxygenation and cell damage during labour. Best Pract Res Clin Obstet Gynaecol. 2015:1-13.
Garabedian C, Jonckheere JD, Butruille L, Deruelle P, Storme L, Debarge VH. Understanding fetal physiology and second line monitoring during labor. J Gynecol Obstet Hum Reprod .2017:1-5
Tuuli MG, Stout MJ, Shanks A, Odibo AO, Macones G, Cahill AG. Umbilical Cord Arterial Lactate Compared with pH for Predicting Neonatal Morbidity at Term. Obstet Gynaecol. 2014; 124(4): 756–61
Allanson ER, White CRH, Tuncalp O, Dickinson JE. Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review.BJOG. 2016: 1-11
Skiold B, Petersson G, Ahilberg M, Stephansson O, Johansson S. Population-based reference curve for umbilical cord arterial pH in infants born at 28 to 42 weeks. J. Perinatol. 2016; (00):1–6.
Gamboa SM, Mancho JP, Rodríguez MR, Sada JR, Mateo SC. pH, base deficit or lactate. Which is better for predicting neonatal morbidity?, J Matern-Fetal Neo M. 2016:1-19.
Fiala M, Baumert M, Surmiak P, Walencka Z, Sodowska P. Umbilical markers of perinatal hypoxia. Ginekol Pol. 2016; (87):200-4.
Guyton A.C and Hall J.E. Buku Ajar Fisiologi Kedokteran Edisi ke-11, PenerbitBuku Kedokteran EGC. Jakarta. 2008:307-400.
Jonsson M, Agren J, Norde´n-Lindeberg S, et al. Neonatal encephalopathy and the association to asphyxia in labor. Am J Obstet Gynecol. 2014;211:1-8.
Ahearne CE, Denihan NM, Walsh BH, et al. Early Cord Metabolite Index and Outcome in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy. Neonatology.2016;110:296-302
Amoozgar H, Barekati M, Farhani N, Pishva N. Effect of Birth Asphyxia on P Wave Dispersion. Indian J Pediatr. 2015: 1-5
Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet 2012; 380: 756-66
Jetton JG, Askenazi DJ. Acute Kidney Injury in the neonate. Clin Perinatol. 2014; 1-16
Mammen C, Al Abbas A, Skippen P, Nadel H, Levine D, Collet JP. Long-term risk of ckd in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study. Am J Kidney Dis. 2012; 59:523-30
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