Keratoakantoma Regio Gluteal

Authors

  • Anggana Raka Paramitasari Bagian/KSM Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr Moewardi, Surakarta, Indonesia
  • Ferry Arrochman Bagian/KSM Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr Moewardi, Surakarta, Indonesia
  • Susanti Rosmala Dewi Bagian/KSM Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr Moewardi, Surakarta, Indonesia
  • Ance Imelda Betaubun Bagian/KSM Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr Moewardi, Surakarta, Indonesia
  • Dendy Zulkar Bagian/KSM Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr Moewardi, Surakarta, Indonesia
  • Endra Yustin Ellista Sari Bagian/KSM Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr Moewardi, Surakarta, Indonesia

DOI:

https://doi.org/10.55175/cdk.v46i5.470

Keywords:

Keratoakantoma, trauma

Abstract

Keratoakantoma (KA) adalah neoplasma jinak sel skuamosa yang jarang berkembang menjadi karsinoma dan bermetastasis. Keratoakantoma sering dijumpai pada daerah terpapar sinar matahari dan secara klinis sulit dibedakan dari karsinoma sel skuamosa (KSS). Walaupun jarang, KA dapat muncul di tempat yang tidak terpapar matahari. Kasus seorang wanita 59 tahun dengan benjolan di bokong sejak 15 tahun yang makin membesar. Pasien pernah dioperasi namun lesi muncul kembali. Hasil pemeriksaan fisik menunjukkan tumor soliter regio gluteal 2 x 2,5 x 0,5 cm sewarna kulit terfiksir, bagian inti berbentuk seperti kawah dengan tepi berbatas tegas. Dermoskopi menunjukkan gambaran massa keratin hitam kekuningan di tengah lesi, dengan zona berwarna keputihan dan struktur vaskuler berbentuk hairpin di sekitar lesi. Pemeriksaan histopatologi menunjukkan tumpukan massa keratin dan nekrotik yang mengarah ke diagnosis KA. Pasien diterapi dengan eksisi luas.

Keratoacanthoma (KA) is a benign neoplasm usually found in sun-exposed body surface. It is rarely developed into metastatic carcinoma, but difficult to be distinguished with squamous cell carcinoma (SCC). Previous surgery, obesity, and scratching lead to chronic trauma in gluteal region can be rare risk factors. The case is a 59 year-old woman with tumour in buttock area for 15 years. The tumour was previously removed but reccurent. Physical examination shows fixed solitary tumor 2 x 2,5 x 0,5 cm, with central yellowish and hyperpigmentation mass. Dermoscopic examination reveals yellowish and black mass in the centre, whitish halo and hairpin vascular pattern around the lesion. Histopathologic examination results keratin mass in the epidermis consistent to KA. This patient was treated with wide excision

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References

Pattee SF, Silvis NG. Keratoacanthoma developing in sites of previous trauma: A report of two cases and review of the literature. J Am Acad Dermatol. 2003;48(2 Suppl):35-8.

Reizner GT, Chuang TY, Elpern DJ, Stone JL, Farmer ER. Keratoacanthoma in Japanese Hawaiians in Kauai, Hawaii. Int J Dermatol. 1995;34(12):851-3.

Chuang TY, Reizner GT, Elpern DJ, Stone JL, Farmer ER. Keratoacanthoma in Kauai, Hawaii. The first documented incidence in a defined population. Arch Dermatol.1993;129(3):317-9.

Tsu-Yi Chuang RB. Keratoacanthoma: WebMD LLC [Internet]. 2015 [cited 2015 Dec 1]. Available from: http://emedicine.medscape.com/article/1100471-overview.

Schwartz RA. Keratoacanthoma. J Am Acad Dermatol. 1994;30(1):1-19.

Drut R. Solitary keratoacanthoma of the nipple in a male. Case report. J Cutan Pathol. 1976;3(4):195-8.

Lorenzo Cerroni HK. Keratoacanthoma. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, eds. Fitzpatrick’s dermatology in general medicine 8. New York: McGraw-Hill Co; 2012. p. 1312-9.

Sarma DP. Keratoacanthoma should be reported as ‘well differentiated squamous cell carcinoma, keratoacanthoma type’: A dermatopathologist’s view. The Internet J Dermatol. 2006;5.

Watanabe IC, Magalhaes RF, de Moraes AM, Stelini RF, Cintra GF, Metze K, et al. Keratoacanthoma and keratoacanthoma-like squamous cell carcinoma: Similar morphology but different pathogenesis. Medicine (Baltimore). 2015;94(23):934.

Wilsmann-Theis D, Wenzel J, Betten HH, Kukuk G, Bieber T, Schmid-Wendtner MH. A rapidly growing squamous cell carcinoma or keratoacanthoma or both? Acta Derm Venereol. 2007;87(5):447-8.

Chaiben CL, Bohn JC, Kuczynski A, Gil FB, de Lima AA. Keratoacanthoma in the inferior lip of an immunosuppressed patient. A case report. Stomatologija. 2013;15(2):61-4.

Benoldi D, Alinovi A. Multiple persistent keratoacanthomas: Treatment with oral etretinate. J Am Acad Dermatol. 1984;10(6):1035-8.

Janik JP, Bang RH. Traumatic keratoacanthoma arising in a 15-year-old boy following a motor vehicle accident. Pediatr Dermatol. 2006;23(5):448-50.

Cabibi D, Conway de Macario E, Ingrao S, Porcasi R, Zucco F, Macario AJ, et al. CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma. Cell Stress Chaperones. 2016;21(1):131-7.

Jason Hadley MH, Payam Tristani-Firouzi. Koebnerizing keratoacanthoma. J Am Acad Dermatol. 2009:AB139.

Lin MJ, Pan Y, Jalilian C, Kelly JW. Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma. Dermatol Pract Concept. 2014;4(2):9-15.

Rosendahl C, Cameron A, Argenziano G, Zalaudek I, Tschandl P, Kittler H. Dermoscopy of squamous cell carcinoma and keratoacanthoma. Arch Dermatol. 2012;148(12):1386-92.

Iris Zalaudek JSG, Bernd Leinweber. Squamous cell carcinoma including actinic keratosis, Bowen’s disease, keratoacanthoma, and its pigmented variants. In: Hans Peter Soyer GA, Rainer Hofmann-Wellenhof, Robert H. Johr, editors. Color atlas of melanocytic lesions of the skin. 1st ed. Germany: Springer-Verlag Berlin Heidelberg; 2007. p. 295-302.

Clausen OP, Aass HC, Beigi M, Purdie KJ, Proby CM, Brown VL, et al. Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization. J Investigative Dermatol. 2006;126:2308-15.

Putti TC, Teh M, Lee YS. Biological behavior of keratoacanthoma and squamous cell carcinoma: Telomerase activity and COX-2 as potential markers. Mod Pathol. 2004;17(4):468-75

Steckelings UM, Artuc M, Paul M, Stoll M, Henz BM. Angiotensin II stimulates proliferation of primary human keratinocytes via a non-AT1, non-AT2 angiotensin receptor. Biochem Biophysic Res Comm. 1996;229(1):329-33

Takeda H, Kondo S. Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression. Am J Pathol. 2001;158(5):1633-7

Kwiek B, Schwartz RA. Keratoacanthoma (KA): An update and review. J Am Acad Dermatol. 2016;74(6):1220-33.

Goldberg LH, Silapunt S, Beyrau KK, Peterson SR, Friedman PM, Alam M. Keratoacanthoma as a postoperative complication of skin cancer excision. J Am Acad Dermatol. 2004;50(5):753-8

Garcia-Zuazaga J, Ke M, Lee P. Giant keratoacanthoma of the upper extremity treated with mohs micrographic surgery: A case report and review of current treatment modalities. J Clin Aesthet Dermatol. 2009;2(8):22-5

Stewart DT. The histological diagnosis of molluscum sebaceum (keratoacanthoma). Aust J Dermatol. 1954;2(4):207-8

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Published

01-05-2019

How to Cite

Paramitasari, A. R., Arrochman, F., Dewi, S. R., Betaubun, A. I., Zulkar, D., & Sari, E. Y. E. (2019). Keratoakantoma Regio Gluteal. Cermin Dunia Kedokteran, 46(5), 367–370. https://doi.org/10.55175/cdk.v46i5.470

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