Suplementasi Vitamin B1 untuk Pasien Sepsis
DOI:
https://doi.org/10.55175/cdk.v47i6.631Keywords:
Sepsis, tiamin, vitamin B1Abstract
Sepsis disertai dengan perubahan metabolisme makronutrien ataupun mikronutrien yang cepat. Banyak pasien sepsis mengalami malnutrisi serta kekurangan vitamin dan mineral akibat peningkatan kebutuhan nutrisi dan pemberian nutrisi yang tidak adekuat, salah satunya defisiensi vitamin B1 atau tiamin. Suplementasi vitamin B1 dapat dipertimbangkan pada pasien sepsis mengingat manfaat vitamin B1 pada metabolisme tubuh.
Sepsis is characterized by rapid changes in both macronutrients and micronutrients metabolism. Numerous septic patients suffer from malnutrition and vitamin or mineral deficiencies due to high nutritional requirement and inadequate nutrition, among others is vitamin B1 or thiamine deficiency. Vitamin B1 supplementation can be considered for septic patients, as there are many benefits of vitamin B1 to body’s metabolism pathways.
Downloads
References
Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: International guidelines for management of sepsis and septic shock: 2016. Crit Care Med. 2017;45:486–552.
Marik P. Hydrocortisone, ascorbic acid and thiamine (HAT therapy) for the treatment of sepsis. Focus on Ascorbic Acid. Nutrients. 2018;10(11):1762.
Shin TG, Kim YJ, Ryoo SM, Hwang SY, Jo IJ, Chung SP, et al. Early vitamin C and thiamine administration to patients with septic shock in emergency departments: Propensity score-based analysis of a before-and-after cohort study. J Clin Med. 2019;8(1):102.
Wischmeyer PE. Nutrition therapy in sepsis. Crit Care Clin [Internet]. 2018;34(1):107–25. Available from: https://doi.org/10.1016/j.ccc.2017.08.008
Irvan I, Febyan F, Suparto S. Sepsis dan tata laksana berdasar guideline terbaru. JAI Jurnal Anestesiol Indones. 2018;10(1):62.
Englert J, Rogers A. Metabolism, metabolomics, and nutritional support of patients with sepsis. Clinics in Chest Medicine. 2016;37(2):321-31.
Dizdar OS, Baspınar O, Kocer D, Dursun ZB, Avcı D, Karakükcü C, et al. Nutritional risk, micronutrient status and clinical outcomes: A prospective observational study in an infectious disease clinic. Nutrients. 2016;8(3):124.
Mallat J, Lemyze M, Thevenin D. Do not forget to give thiamine to your septic shock patient! J Thorac Dis. 2016;8(6):1062–6.
Moskowitz A, Andersen LW, Huang DT, Berg KM, Grossestreuer AV, Marik PE, et al. Ascorbic acid, corticosteroids, and thiamine in sepsis: A review of the biologic rationale and the present state of clinical evaluation. Crit Care. 2018;22(1):1–7.
Martel JL, Franklin DS. Vitamin B1 (thiamine) [Updated 2019 Jan 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482360/
Donnino M, Andersen L, Chase M, Berg K, Tidswell M, Giberson T, et al. Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock. Critical Care Medicine. 2016;44(2):360-7.
Collie JTB, Greaves RF, Jones OAH, Lam Q, Eastwood GM, Bellomo R. Vitamin B1 in critically ill patients: Needs and challenges. Clin Chem Lab Med. 2017;55(11):1652–68.
Donnino MW, Carney E, Cocchi MN, Barbash I, Chase M, Joyce N, et al. Thiamine deficiency in critically ill patients with sepsis. J Crit Care 2010;25(4):576–81.
Woolum JA, Abner EL, Kelly A, Bastin MLT, Morris PE, Flannery AH. Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Crit Care Med. 2018;46(11):1747–52.
Amrein K, Oudemans-van Straaten HM, Berger MM. Vitamin therapy in critically ill patients: Focus on thiamine, vitamin C, and vitamin D. Intensive Care Med [Internet]. 2018;44(11):1940–4. Available from: https://doi.org/10.1007/s00134-018-5107-y
Fernández López M, López Otero M, Álvarez Vázquez P, Arias Delgado J, Varela Correa J. Refeeding syndrome. Farmacia Hospitalaria (English Edition). 2009;33(4):183-93.
Van Stigt RM, Van Der Wal G, Kamphuis S, Braber A. Beriberi in the ICU: Remarkable shock reversal with thiamine. Netherlands J Crit Care. 2019;27(2):93–6.
Lei Y, Zheng MH, Huang W, Zhang J, Lu Y. Wet beriberi with multiple organ failure remarkably reversed by thiamine administration. Med (United States). 2018;97(9):5–9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Cermin Dunia Kedokteran
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
