Manfaat Diet Ketogenik pada Tata Laksana Obesitas


  • ibadityan Nugraha Medical Faculty of Udayana University



Badan keton, diet ketogenik, obesitas


Obesitas merupakan faktor risiko kuat untuk penyakit kardiovaskular dan metabolik, seperti diabetes melitus tipe 2, dislipidemia, aterosklerosis, dan beberapa jenis kanker. Diet adalah salah satu strategi manajemen obesitas. Diet ketogenik adalah diet tinggi lemak dan rendah karbohidrat, memanfaatkan badan keton sebagai sumber energi alternatif. Dalam jangka pendek, jenis diet ini terbukti efektif menurunkan berat badan individu obesitas. Penelitian lebih lanjut diperlukan untuk menentukan efikasi, keamanan, dan efek samping jangka panjangnya.


Obesity is a strong risk factor for cardiovascular and metabolic diseases, such as type 2 diabetes mellitus, dyslipidemia, atherosclerosis, and certain types of cancer. Diet is one of many strategies in obesity management. Ketogenic diet is a high fat and low carbohydrate diet, utilizing ketone bodies as an alternative energy source. In short term, this diet has proven to be effective for weight loss in obese individuals. Further researches are needed to determine its efficacy, safety, and long term side effects.



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Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13-27. doi: 10.1056/NEJMoa1614362.

Smith KB, Smith MS. Obesity statistics. Prim Care 2016;43(1):121-35, ix. doi: 10.1016/j.pop.2015.10.001.

Baker C. Obesity statistics. House of common library [Internet]. 2021. Available from:

Wise J. Severe obesity in year 6 children in England reaches new high. BMJ 2019;367:l5986. doi: 10.1136/bmj.l5986.

Paoli A. Ketogenic diet for obesity - friend or foe. Int J Environ Res Public Health 2014;11(2):2092–107.

Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long‐term weight management. J Am Assoc Nurse Pract. 2017;29(Suppl 1):3–14. doi: 10.1002/2327-6924.12510.

Iwatate E, Atem FD, Jones EC, Hughes JL, Yokoo T, Messiah SE. Association of obesity, suicide behaviors, and psychosocial wellness among adolescents in the United States. J Adolesc Health. 2023;72(4):526-34. doi:10.1016/j.jadohealth.


Lin X, Li H. Obesity: Epidemiology, pathophysiology, and therapeutics. Front Endocrinol (Lausanne). 2021;2:706978. doi: 10.3389/fendo.2021.706978.

Hruby A, Hu FB. The epidemiology of obesity: A big picture. Pharmacoeconomics 2015;33(7):673–89. doi:10.1007/s40273-014-0243-x.

Diana R, Atmaka DR. Ketogenic diet for weight loss and its implication on health: A literature study. Media Gizi Indon (Nat Nutr J). 2020;15(3):184–93.

Carreiro AL, Dhillon J, Gordon S, Jacobs AG, Higgins KA, Jacobs AG, et al. The macronutrients, appetite and energy intake. Annu Rev Nutr. 2016;36:73–103. doi: 10.1146/annurev-nutr-121415-112624.

Drabinska N, Wiczkowski W, Piskula K. Recent advances in the application of ketogenic diet for obesity management. Trends in Food Sci Technol. 2021;110:28–38.

Kelly T, Unwin D, Finucane F. Low-carbohydrate diets in the management of obesity and type 2 diabetes: A review from clinicians using the approach in practice. Int J Environ Res Public Health 2020;17:2557. doi:10.3390/ijerph17072557.

Oh R, Gilani B, Uppaluri KR. Low carbohydrate diet. StatPearls Publishing LLC [Internet]. 2019. Available from: https://www.ncbi.nlm.nih. gov/books/NBK537084.

Kalra S, Singla R, Rosha R, Dhawan M, Khandelwal D, Kaira B. The ketogenic diet. US Endocrinol. 2018;14(2):62–4.

Meira D, Romao TT, do Prado HJP, Kruger LT, Pires MEP, de Conceicao PO. Ketogenic diet and epilepsy: What we know so far. Front Neurosci. 2019;13:1–8.

Gupta L, Khandelwal D, Kalra S, Gupta P, Dutta D, Aggarwal S. Ketogenic diet in endocrine disorders: Current perspectives. J Postgrad Med. 2017;63(4):242–51. doi: 10.4103/jpgm.JPGM_16_17.

Kirkpatrick CF, Bolick JP, Kris-Etherton PM, Sikand G, Aspry KE, Soffer DE, et al. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: A scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. J Clin Lipidol. 2019;13(5):689-711.e1. doi: 10.1016/j.jacl.2019.08.003.

Murata Y, Nishio K, Mochiyama T, Konishi M, Shimada M, Ohta H, et al. Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet. PLoS One. 2013;8:e69330. doi: 10.1111/cen.12095.

Woo YC, Xu A, Wang Y, Lam KS. Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives. Clin Endocrinol (Oxf). 2013;78:489–96. doi: 10.1111/cen.12095.

Abbasi J. Interest in the ketogenic diet grows for weight loss and type 2 diabetes. JAMA. 2018;319(3):215–7.

Barrea L, Verde L, Vetrani C, Marino F, Aprano S, Savastano S, et al. VLCKD: A real time safety study in obesity. J Transl Med [Internet]. 2022. Available from:

Merra G, Gratteri S, De Lorenzo A, Barrucco S, Perrone MA, Avolio E, et al. Effects of very-low-calorie diet on body composition, metabolic state, and genes expression: A randomized double-blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2017;21(2):329–45.

Muscogiuri G, Barrea L, Laudisio D, Pugliese G, Salzano C, Savastano S, et al. The management of very low-calorie ketogenic diet in obesity outpatient clinic: A practical guide. J Transl Med. 2019;17:356.

Muscogiuri G, El Ghoch M, Colao A, Hassapidou M, Yumuk V, Busetto L, et al. European guidelines for obesity management in adults with a very low-calorie ketogenic diet: A systematic review and meta-Analysis. Obes Facts 2021;14(2):222-45. doi: 10.1159/000515381.

Moreno C, Poplawski P, Mastaitis J, Mobbs C. Mechanism by which the ketogenic reverses obesity and diabetes. Endocrin Metabolism J 2017;4(6):00107. doi: 10.15406/emij.2017.04.00107.

Smith ES, Betts JA, Gonzalez JT. A systematic review and meta-analysis comparing heterogeneity in body mass responses between low carbohydrate and low fat diets. Obesity 2020;28(10):183-42.

Bueno NB, de Melo IS, de Oliveira SL, da Rocha Ataide T. Very- low- carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: A meta- analysis of randomised controlled trials. Br J Nutr. 2013;110(7):1178–87.

Gardner CD, Trepanowski JF, Del Gobbo LC, Hauser ME, Rigdon J, Ioannidis JPA, et al. Effect of low-fat vs low- carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: The DIETFITS randomized clinical trial. JAMA. 2018;319(7):667–79. doi:10.1001/jama.2018.0245.

Volek JS, Phinney SD. The art and science of low carbohydrate living. Beyond Obesity, LLC; 2011.

Waterloo Wellington Diabetes. The ketogenic/low carbohydrate diet & diabetes: A guide for health care professionals. WWD Working Group; 2020.

Hall KD, Chen KY, Guo J, Lam YY, Leibel RL, Mayer LE, et al. Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men. Am J Clin Nutr. 2016;104(2):324–33.

Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Circulation 2014;129(25Suppl2):102–38. doi: 10.1161/

Shah ND, Limketkai BN. The use of medium-chain tryglicerides in gastrointestinal disorders [Internet]. 2017. Available from:




How to Cite

Nugraha, ibadityan, GOTERA, W., & LESTARI SUGITHA, K. S. (2023). Manfaat Diet Ketogenik pada Tata Laksana Obesitas. Cermin Dunia Kedokteran, 50(8), 451–458.