Profil Respons Glukosa Darah dan Tingkat Rasa Kenyang setelah Pemberian Diabetasol® Dibandingkan Makanan Padat Gizi Terkontrol pada Pasien Diabetes Melitus tipe 2
DOI:
https://doi.org/10.55175/cdk.v45i7.749Keywords:
Diabetes melitus tipe 2, inulin, isomaltulosa, makanan rendah glikemik indeks, rasa kenyang, resistant dextrin, respons glikemikAbstract
Tujuan penelitian ini adalah untuk menentukan stabilitas kadar glukosa darah harian, tingkat kenyang, dan keamanan setelah menggunakan Diabetasol® dibandingkan dengan makanan padat dengan gizi terkontrol. Diabetasol® adalah makanan indeks glikemik rendah mengandung isomaltulosa, resisten dekstrin, dan inulin. Penelitian ini merupakan studi awal, prospektif, acak, terbuka, dan melibatkan 30 subjek DM tipe 2 pria dan wanita. Pengukuran glukosa darah dengan continuous glucose monitoring selama 48 jam di setiap kunjungan. Tingkat rasa kenyang diukur dengan kuesioner satiety quotient dengan visual analog scale (VAS) pada interval 0, 15, 30, 60, dan 120 menit. Evaluasi efek samping didasarkan pada terjadinya hipoglikemia dan masalah pencernaan selama masa pengobatan. Hasil penelitian menunjukkan respons glikemik Diabetasol® lebih rendah dibandingkan makanan padat gizi terkontrol kendati tidak bermakna, di lain pihak Diabetasol® memberikan rasa kenyang lebih lama tanpa efek samping serius.
The purpose of this study was to determine the stability of daily blood glucose level, satiety level, and safety after using Diabetasol® in comparison with controlled nutrition solid food. Diabetasol® is low glycemic index foods contained of isomaltulose, resistant dextrin, and inulin. This study is a preliminary, prospective, randomized, open-ended study, and involving 30 male and female type 2 DM subjects. Blood glucose was measured with continuous glucose monitoring within 48 hours after every visit. The satiety level was measured with satiety quotient questionnaire with visual analog scale (VAS) at interval of 0, 15, 30, 60, and 120 minutes. The evaluation of side effects was based on the occurrence of hypoglycemia and digestive problems during the treatment period. Eventhough not stastistically significant, Diabetasol® leads to decreased glycemic response and longer satiety compared to controlled nutrition solid foods, with no serious side effects.
Downloads
References
Departemen Kesehatan 2013. Laporan riset kesehatan dasar (Riskerdas) bidang kesehatan. Jakarta: Badan Litbangkes, Depkes RI; 2013.
International Diabetes Federation. The International Federation (IDF) Diabetes Atlas, 7th ed [Internet]. 2015. Available from http://www.diabetesatlas.org/
World Health Organization. Global report on diabetes [Internet]. 2016. Available from: http://apps.who.int/iris/bitstream/handle/10665/204871/9789241565257_eng.pdf;jsessionid=197F36AD567D5EA3706B42788DB87975?sequence=1
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-53.
Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Low-glycemic index diets in the management of diabetes: A meta-analysis of randomized controlled trials. Diabetes Care 2003;26(8):2261-7
Thomas DE, Elliot EJ. Meta-analysis: The use of low-glycemic index diets in diabetes control. Br J Nutr. 2010;104:797-802
Chen H, Shaw M.Janet, Moyer-Mileur JL. The new glucose revolution: Is the authoritative guide to the glycemic index the right dietary solution for lifelong health. Internat J Nutr Metabolism. 2010;2(5):73-81.
Kaur B, Ranawana V, Teh Ai-Ling, Henry CJK. The impact of low glycemic index (GI) breakfast and snack on daily blood glucose profiles and food intake in young Chinese adult males. J Clin Translat Endocrinol. 2015;2:92-8
Waspadji S, Sukardji K, Rimbawan, Sulaeman A, Aitonam M. Glycemic index of Diabetasol on type-2 diabetes outpatient in Dr. Cipto Mangunkusumo National Hospital. 2011
Alison DB, Paultre F, Maggio C, Mezzitis N, Pi-Sunyer FX, The use of areas under curves in diabetes research. Diabetes Care. 1995;18(2):245-50
University of Leeds (UNIVLEEDS). Satin (Satiety Innovation) - D4.3: Satiety Methodology. Work Package 4; 2016
Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G, et.al. Glycaemic index methodology. Nutr Res Rev. 2005;18:145-71
Augustin LSA, Kendall CWC, Jenkins DJA, Willett WC, Astrup A, Barclay AW, et al. Glycemic index, glycemic load and glycemic response: An International scientific consensus summit from the International Carbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis. 2015;25:795-815
Monnier L. Is postprandial glucose a neglected cardiovascular risk factor in type 2 diabetes? Eur J Clin Invest. 2000;30(suppl 2):3-11
Gribovschi M, Tgan S, Hancu N. Glycemic Variability and Type 2 Diabetes Mellitus. Appl Med Inform.2013,32(1):53-60
Wahren J, Ekberg K. Splanchnic regulation of glucose production. Ann Rev Nutr. 2007;27:329-45
Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values: 2008. Diabetes Care. 2008;31:2281-3
Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. Am J Clin Nutr. 2013;97:505-16
Maresch CB, Petry SF, Theis S, Westhpal AB, Linn T. Low glycemic index prototype isomaltulose-update of clinical trials. Nutrients. 2017;9:381-42
Bodinham CL, Smith L, Thomas EL, Bell JD, Swann JR, Costabile A, et al. Efficacy of increased resistant starch consumption in human type 2 diabetes. Endocrine Connection. 2014;3:75-83
Mukai J, Tsuge Y, Yamada M, Otori K, Atsuda K. Effects of resistant dextrin for weight lossing overweight adults: A systematic review with a meta-analysis of randomized controlled trials. J Pharm Health Care Sci. 2017;3:15-21
Aliasgharzadeh A, Dehghan P, Gargari BP, Jafarabadi MA. Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: A randomized controlled clinical trial. Br J Nutr. 2015;113:321-30
Aliasgharzadeh A, Khalili M, Mirtaheri E, Gargari BP, Tavakoli F, Farhangi MA, et al. A combination of prebiotic inulin and oligofructose improve some of cardiovascular disease risk factors in women with type 2 diabetes: A randomized controlled clinical trial. Adv Pharm Bul. 2015;5(4):507-14
Heap S, Ingram J, Law M, Tucker AJ and Wright AJ. Eight-day consumption of inulin added to a yogurt breakfast lowers postprandial appetite ratings but not energy intakes in young healthy females: a randomised controlled trial. Br J Ntr. 2016;115: 262–270
Monsivais P, Carter BE, Christiansen M, Perrigue MM and Drewnowski A. Soluble fiber dextrin enhances the satiating power of beverages. Appetite. 2011;56: 9–14
de Medeiros Batista SM, Moreira EAM, Fiates GMR, de Assis MAA and Teixeira E. Effect of low glycaemic index diets on satiety. British Food Journal. 2014;116(8):1233-46
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
