Mikrobiom pada Genitalia Laki-Laki dan Hubungannya dengan Infeksi Menular Seksual
DOI:
https://doi.org/10.55175/cdk.v48i7.92Keywords:
mikrobiom, PMS, Genital laki-lakiAbstract
Mikrobiom adalah keseluruhan mikroorganisme, genom, dan kondisi lingkungan sekitar di dalam ekosistem tertentu, seperti kulit. Tubuh manusia menjadi tempat berbagai macam mikrobiota, yang diketahui memiliki peran penting. Bukti pertama mikrobiota traktus urogenital laki-laki berasal dari beberapa penelitian berbasis kultur pada tahun 1970-an. Mikrobiota genital pada anak dan dewasa berbeda; lokasi, komposisi urin, pengaruh sirkumsisi, dan aktivitas seksual juga memengaruhi keragaman. Mikrobiota genital laki-laki dapat berkaitan dengan infeksi menular seksual seperti uretritis, ulkus genital, HIV, balanitis, serta interaksi dengan mikrobiota genital perempuan dan rektum lelaki seks dengan lelaki.
Microbiome is a whole community that consists of microorganisms, genomes, and surrounding environmental conditions inside certain ecosystems, such as human skin. Human body is a habitat to a variety of important microbiota. The first evidence of male urogenital tract microbiota came from several culture-based studies in the 1970s. Genital microbiota in children and adults is different; location, urine composition, the effect of circumcision, and sexual activity also cause a diversity of microbiota. Male genital microbiota is also associated with sexually transmitted infections such as urethritis, genital ulcers, HIV, balanitis, and interactions with female genital microbiota and rectum of men who have sex with men.
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References
Kong H. Microbiome of the skin. In: Fitzpatrick’s dermatology. 9th ed. New York: McGraw Hill Medical; 2019. p. 253–64.
Marchesi J, ed. The human microbiota and microbiome. Wallingford, Oxfordshire, UK ; Boston, MA, USA: CABI; 2014. 197 p. (Advances in Molecular and Cellular Microbiology).
Henderson B, Nibali L, eds. The human microbiota and chronic disease: Dysbioses as a cause of human pathology. Hoboken, New Jersey: Wiley Blackwell; 2016.
Schwiertz A. Microbiota of the human body: Implications in health and disease. New York, NY: Springer Berlin Heidelberg; 2016.
Nelson DE, Dong Q, Van Der Pol B, Toh E, Fan B, Katz BP, et al. Bacterial communities of the coronal sulcus and distal urethra of adolescent males. Ravel J, ed. PLoS ONE. 2012;7(5):e36298.
Frølund M, Wikström A, Lidbrink P, Abu Al-Soud W, Larsen N, Harder CB, et al. The bacterial microbiota in first-void urine from men with and without idiopathic urethritis. Fredricks DN, ed. PLoS ONE. 2018;13(7):e0201380.
Gottschick C, Deng ZL, Vital M, Masur C, Abels C, Pieper DH, et al. The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment. Microbiome. 2017;5(1):99.
Brotman RM, Ravel J, Bavoil PM, Gravitt PE, Ghanem KG. Microbiome, sex hormones, and immune responses in the reproductive tract: Challenges for vaccine development against sexually transmitted infections. Vaccine. 2014;32(14):1543–52.
Morris BJ, Krieger JN. Balanitis and related inflammatory conditions affecting the penis. 2018 Mar 15 [cited 2019 Jul 14]. Available from: https://books.publisso.de/publisso_gold/book/52/chapter/22
Bentubo HDL, Mantovani A, Yamashita JT, Gambale W, Fischman O. Yeasts of the genital region of patients attending the dermatology service at Hospital São Paulo, Brazil. Rev Iberoam Micol. 2015;32(4):229–34.
Liu CM, Hungate BA, Tobian AAR, Serwadda D, Ravel J, Lester R, et al. Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria. Onderdonk AB, ed. mBio. 2013;4(2):e00076-13.
Liu CM, Prodger JL, Tobian AAR, Abraham AG, Kigozi G, Hungate BA, et al. Penile anaerobic dysbiosis as a risk factor for HIV infection. Blaser MJ, ed. mBio.w 2017;8(4):e00996-17, /mbio/8/4/e00996-17.atom.
Mehta SD, Green SJ, Maclean I, Hu H, Bailey RC, Gillevet PM, et al. Microbial diversity of genital ulcer disease in men enrolled in a randomized trial of male circumcision in Kisumu, Kenya. Broliden K, ed. PLoS ONE. 2012;7(7):e38991.
Salas JT, Chang TL. Microbiome in human immunodeficiency virus infection. Clin Lab Med. 2014;34(4):733–45.
Zozaya M, Ferris MJ, Siren JD, Lillis R, Myers L, Nsuami MJ, et al. Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis. Microbiome. 2016;4(1):16.
Liu CM, Hungate BA, Tobian AAR, Ravel J, Prodger JL, Serwadda D, et al. Penile microbiota and female partner bacterial vaginosis in Rakai, Uganda. Pettigrew MM, ed. mBio. 2015 6;6(3):e00589-15.
Morris BJ, Hankins CA, Banerjee J, Lumbers ER, Mindel A, Klausner JD, et al. Does male circumcision reduce women’s risk of sexually transmitted Infections, Cervical Cancer, and Associated Conditions? Front Public Health. 2019;7:4.
Pescatore NA, Pollak R, Kraft CS, Mulle JG, Kelley CF. Short communication: Anatomic site of sampling and the rectal mucosal microbiota in HIV negative men who have sex with men engaging in condomless receptive anal intercourse. AIDS Res Hum Retroviruses. 2018;34(3):277–81.
Nowak RG, Bentzen SM, Ravel J, Crowell TA, Dauda W, Ma B, et al. Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria: AIDS. 2017;31(6):857–62.
Hocking JS, Kong FYS, Timms P, Huston WM, Tabrizi SN. Treatment of rectal chlamydia infection may be more complicated than we originally thought. J Antimicrob Chemother. 2014;dku493.
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