Terapi Non-Invasive Continuous Positive Airway Pressure (CPAP) Ventilation pada Keracunan Gas Karbon Monoksida


  • Dedy Kristofer Simangunsong Dokter Umum
  • Septo Sulistio RSCM Jakarta
  • Eirene Simbolon RSON Jakarta
  • Erwin Kristianto Simangunsong Puskesmas Ambarita, Samosir, North Sumatera




Carbon monoxide poisoning, non-invasive CPAP ventilation hyperbaric, oxygen therapy, normobaric oxygen therapy


Carbon monoxide (CO) poisoning is one of the leading environmental emergencies with high mortality and morbidity. The brain and heart are especially at-risk organs of being affected. Clinical manifestations may closely mimic various nonspecific viral illnesses. Diagnosis is made based on of clinical symptoms, patient history, and the location’s circumstances. Current therapy recommendations for CO poisoning are 100% normobaric oxygen (NBO) or hyperbaric oxygen (HBO). Non-invasive ventilation CPAP (continuous positive airway pressure) method is effective as a therapy for CO poisoning in the emergency room because it can provide tissue oxygenation and eliminate CO quickly.


Download data is not yet available.


Idil H, Unek O. Non-invasive CPAP ventilation in acute carbon monoxide poisoning. Prehospital and Disaster Medicine 2019;34(4):454-5.

Nasronudin. Keracunan karbon monoksida. In: Setiati S, Alwi I, Sudoyo AW, Simadibrata, M, Setiyohadi B, Syam AF. Buku ajar penyakit dalam. Vol I. 6th Ed. Jakarta: Interna Publishing; 2014. p. 1065-70.

Eichhorn L, Thudium M, Jüttner B. The diagnosis and treatment of carbon monoxide poisoning. Dtsch Arztebl Int. 2018;115:863–70.

Kinoshita H, Türkan H, Vucinic H, Naqvi S, Bedair R, Rezaee R, et al. Carbon monoxide poisoning. Toxicol Rep. 2020;7:169–73.

Christensen GM, Creswell PD, Meiman JG. Carbon monoxide exposure and poisoning cases in Wisconsin, 2006–2016. WJM. 2019;118(1):21-6.

Davico C, Notari D, Larosa P, Ricci F, Vittorini R, Cogoni M, et al. Carbon monoxide intoxication: A case of misdiagnosis with neuroradiological follow up. J Neurol Neurosci. 2016;(1):78.

Jang HJ, Piel S, Greenwood JC, Ehinger JK, Kilbaugh TJ. Emerging cellular-based therapies in carbon monoxide poisoning. Am J Physiol Cell Physiol. 2021;321:269–75.

Han E, Yu G, Lee HS, Park G, Chung SP. Prevalence of carbon monoxide poisoning and hyperbaric oxygen therapy in Korea: Analysis of national claims data in 2010–2019. J Korean Med Sci. 2023 Apr 17;38(15):e125.

Mehta SR, Das S, Singh SK. Carbon monoxide poisoning. MJAFI. 2007;63:362-5.

Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, et al. Carbon monoxide poisoning: Pathogenesis, management, and future directions of therapy. Am J Respir Crit Care Med. 2017;195(5):596–606.

Weaver LK. Carbon monoxide poisoning. NEJM. 2009;360(12):1217-25.

Jüttner B, Busch H, Callies A, Dormann H, Janisch T, Kaiser G, et al. S2k guideline diagnosis and treatment of carbon monoxide poisoning. GMS German Medl Sci. 2021;19:Doc13.

Gozubuyuk AA, Dag H, Kacar A, Karakurt Y, Arica V. Epidemiology, pathophysiology, clinical evaluation, and treatment of carbon monoxide poisoning in child, infant, and fetus. North Clin Istanb. 2017;4(1):100–7.

Richards JB, Wilcox SR. Diagnosis and management of shock in the emergency department. Emerg Med Pract. 2014 Mar;16(3):1-22.

Marx JA, Hockberger RS, Walls RM, Biros MH, Danzl DF, Gausche-Hill M, et al. Rosen’s emergency medicine. Concepts and clinical practice. Vol. 2. 8th Ed. Philadelphia: Elsevier Inc.; 2014. p. 2041-3.

Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. Pedoman tata laksana sindrom koroner akut. 4th Ed. Jakarta: PERKI; 2018 .p. 28-31.

Lee HD, Lee SY, Cho Y, Han SH, Park S, Lee KH. Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication. Medicine 2018;97:23(e11051).

Torres PA, Helmstetter JA, Kaye AM, Kaye AD. Rhabdomyolysis: Pathogenesis, diagnosis, and treatment. The Ochsner Journal 2015;15:58–69, 2015.

Ning K, Zhou Y, Zhang N, Sun X, Liu W, Han C. Neurocognitive sequelae after carbon monoxide poisoning and hyperbaric oxygen therapy. Med Gas Res. 2020;10(1):30-6.

Roth D, Mayer J, Schreiber W, Herkner H, Laggner AN. Acute carbon monoxide poisoning treatment by non-invasive CPAP ventilation, and by reservoir face mask: Two simultaneous cases. Am J Emergency Med. 2018;36:1718.e5–1718.e6.

Casillas S, Galindo A, Camarillo-Reyes LA, Varon J, Surani SR. Effectiveness of hyperbaric oxygenation versus normobaric oxygenation therapy in carbon monoxide poisoning: A systematic review. Cureus 2019;11(10):e5916.

Köhler A, Zoll FM, Ploner T, Hammer A, Joannidis M, Tilg H, et al. Oxygenation performance of different non-invasive devices for treatment of decompression illness and carbon monoxide poisoning. Front Physiol. 2022;13:885898.

.Turgut K, Yavuz E. Comparison of non-invasive CPAP with mask use in carbon monoxide poisoning. Am J Emergency Med. 2020;38(7):1454-7.

Caglar B, Serin S, Yilmaz G, Torun A, Parlak I. The impact of treatment with continuous positive airway pressure on acute carbon monoxide poisoning. Prehosp Disaster Med. 2019.;00(00):1–4



How to Cite

Simangunsong, D. K., Sulistio, S., Simbolon, E., & Simangunsong, E. K. (2024). Terapi Non-Invasive Continuous Positive Airway Pressure (CPAP) Ventilation pada Keracunan Gas Karbon Monoksida. Cermin Dunia Kedokteran, 51(2), 76–81. https://doi.org/10.55175/cdk.v51i2.1022