Pengaruh Citicoline terhadap Tingkat Keparahan dan Status Fungsional Pasien Stroke Iskemik
Laporan Kasus Berbasis Bukti
DOI:
https://doi.org/10.55175/cdk.v51i4.1052Keywords:
Citicoline, severity, functional status, ischemic strokeAbstract
Background: Stroke is a cause of long-term mortality, morbidity, and disability. Neuroprotectors, such as citicoline, are a choice for patients not eligible for rTPA. This evidence-based case report aims to look at the association of citicoline with the severity and functional status of ischemic stroke. Method: The search is based on the database Scopus. A total of 191 studies were reviewed, and 3 articles were chosen for critical review: Ghosh, et al, (2015), Martynov, et al, (2013), and Mehta, et al, (2019). Results: Significant differences in functional status measured by the Barthel index and modified Rankin Scale (mRS) and severity measured by the NIHSS. Conclusion: Citicoline has a significant effect on the functional status and severity of an ischemic stroke.
Downloads
References
Kogan E, Twyman K, Heap J, Milentijevic D, Lin JH, Alberts M. Assessing stroke severity using electronic health record data: A machine learning approach. BMC Med Informatics and Decision Making. 2020;20(1):8.
Strini V, Piazzetta N, Gallo A, Schiavolin R. Barthel Index: Creation and validation of two cut-offs using the BRASS Index. Acta Biomed. 2020;91(2-s):19-26.
Wang Y, Du W, Yang X, Yan J, Sun W, Bai J, et al. Diagnosis and differential diagnosis flow diagram of Chinese post-stroke aphasia types and treatment of post-stroke aphasia. Aging Med. 2021;4(4):325-36.
Martynov MY, Gusev EI. Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. J Experimental Pharmacol. 2015;7:17-28.
Álvarez-Sabín J, Román GC. The role of citicoline in neuroprotection and neurorepair in ischemic stroke. Brain Sci. 2013;3(3):1395-414.
Martí-Carvajal AJ, Valli C, Martí-Amarista CE, Solà I, Martí-Fàbregas J, Bonfill Cosp X. Citicoline for treating people with acute ischemic stroke. Cochrane Database of Systematic Rev. 2020;2020(8).
Overgaard K. The effects of citicoline on acute ischemic stroke: A review. J Stroke Cerebrovasc Dis. 2014;23(7):1764-9.
Shrestha S, Poudel RS, Khatiwada D, Thapa L. Stroke subtype, age, and baseline NIHSS score predict ischemic stroke outcomes at 3 months: A preliminary study from Central Nepal. J Multidiscip Healthc. 2015;8:443-8.
University of Oxford. Critical appraisal tools [Internet]. 2023 [cited 2023 June 25] Available from: https://www.cebm.ox.ac.uk/resources/ebm-tools/ritical-appraisal-tools
Ghosh S, Das SK, Nath T, Ghosh KC, Bhattacharyya R, Mondal GP. The effect of citicoline on stroke: A comparative study from the Eastern part of India. Neurology India. 2015;63(5):697-701.
.Martynov MY, Boiko AN, Kamchatnov PR, Kabanov AA, Yasamanova AN, Shchukin IA, et al. Neuroprotective therapy with citicoline (Ceraxon) in patients with ischemic stroke. Neurosci Behavioral Physiol. 2013;43(6):706-11.
12. Mehta A, Mahale R, Buddaraju K, Javali M, Acharya P, Srinivasa R. Efficacy of neuroprotective drugs in acute ischemic stroke: Is it helpful? J Neurosci in Rural Pract. 2019;10(4):576-81.
Moraney, R., Poupore, N., Shugart, R., Tate, M., Snell, A., Brown, K., et al. Thrombolytic therapy in ischemic stroke patients with pre-stroke depression in the Telestroke vs non-telestroke. Journal of Stroke and Cerebrovascular Diseases, 2020; 29(9):104890.
Agarwal A, Vishnu VY, Sharma J, Bhatia R, Garg A, Dwivedi S, et al. Citicoline in acute ischemic stroke: A randomized controlled trial. PLoS ONE. 2022;17(5 May).
Shi PY, Zhou XC, Yin XX, Xu LL, Zhang XM, Bai HY. Early application of citicoline in the treatment of acute stroke: A meta-analysis of randomized controlled trials. J Huazhong Univ Sci Technol - Med Sci. 2016;36(2):270-7.
Premi E, Cantoni V, Benussi A, Gilberti N, Vergani V, Delrio I, et al. Citicoline treatment in acute ischemic stroke: A randomized, single-blind TMS study. Front Neurol. 2022;13:915362.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Yosefin Joenadi, Dedi Joenadi
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
