Benefits of Citicoline in Ischemic Stroke Management


  • Endy Juli Anto Faculty of Medicine, Methodist University of Indonesia, Medan
  • Jekson Martiar Siahaan Faculty of Medicine, Methodist University of Indonesia, Medan
  • Putri Chairani Eyanoer Faculty of Medicine, University of North Sumatra, Medan, Indonesia



Citicoline, electrolite imbalance, ischemic stroke


Background: Stroke is the third most common disease after heart disease and cancer and the main cause of disability worldwide. The most common type of stroke, which accounts for around 85%-87% of cases, is ischemic stroke (IS). This report is to examine the benefits of citicoline for IS patients. Case: A 63-year-old male was admitted with a diagnosis of IS and electrolyte disturbances. General treatment is semi-Fowler’s position, oxygen, and maintaining fluid and nutritional intake. Specific management is RL infusion 20 gtt/minute, candesartan 1x16 mg, clopidogrel 1x75 mg, omeprazole 40 mg/24 h intravenous (IV), and citicoline 500 mg/12 h IV. The patient showed clinical improvement. Method: Articles in PubMed, Cochrane, and Google Scholar in February-April 2022 were searched to find relevant studies to be evaluated with inclusion and exclusion criteria. The full text was obtained and critically reviewed with the evidence-based medicine guidelines. The results are limited to systematic reviews and meta-analyses. Results: Five studies were deemed valid, important, and applicable. However, the quality of these studies varies. Conclusion: All studies show that citicoline use could potentially improve clinical outcomes in IS patients.


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Author Biographies

Jekson Martiar Siahaan, Faculty of Medicine, Methodist University of Indonesia, Medan

dosen bagian fisiologi di fakultas kedokteran universitas methodist indonesia

Putri Chairani Eyanoer, Faculty of Medicine, University of North Sumatra, Medan, Indonesia

dosen bagian epidemiologi di fakultas kedokteran USU


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How to Cite

Juli Anto, E., Siahaan, J. M., & Eyanoer, P. C. (2024). Benefits of Citicoline in Ischemic Stroke Management. Cermin Dunia Kedokteran, 51(5), 280–286.