Mucocutaneous Defense Mechanisms against Candida Infection

Analysis

Authors

  • Adelia Wuri Pramudita Recidency Program in Dermatovenereology Departement, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University
  • Harijono Kariosentono Dermatovenereology Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Annisa Marsha Evanti Dermatovenereology Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Zilpa Widyastuti Dermatovenereology Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia

DOI:

https://doi.org/10.55175/cdk.v52i3.1157

Keywords:

adaptive immunity, candida, defense mechanism, innate immunity, mucocutaneous

Abstract

Candida albicans is a commensal organism that can may become invasive and fatal under certain circumstances. Several genetic variations in the human genome towards susceptibility to Candida infections have been identified. There are a number of genes associated with Candida virulence factors, host environment, and immune response. C-type lectin receptors (CLRs) are characterized by leucine-rich and nucleotidebinding domains that can detect intracellular signals through various types of cytoplasmic domains. CLRs are family of PRRs that bind glycan through recognition of extracellular carbohydrate and mediate intracellular signaling through various type of cellular domains, resulting in a decrease of neutrophils and facilitating the occurrence of fungal infections. This study review the genetic determinant of defense mechanisms and immune deficiencies against Candida infection.

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Published

05-03-2025

How to Cite

Pramudita, A. W., Kariosentono, H., Evanti, A. M., & Widyastuti, Z. (2025). Mucocutaneous Defense Mechanisms against Candida Infection: Analysis. Cermin Dunia Kedokteran, 52(3), 208–213. https://doi.org/10.55175/cdk.v52i3.1157