Mekanisme Pertahanan Mukokutan terhadap Infeksi Candida
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DOI:
https://doi.org/10.55175/cdk.v52i3.1157Kata Kunci:
candida, imunitas adaptif, imunitas bawaan, mekanisme pertahanan, mukosaAbstrak
Candida albicans adalah organisme komensal yang dapat menjadi invasif dan fatal dalam keadaan tertentu. Ada beberapa variasi genetik dalam genom manusia yang telah diidentifikasi memiliki kerentanan terhadap infeksi Candida. Terdapat sejumlah gen yang berhubungan dengan faktor virulensi Candida, lingkungan inang, dan respons imun tubuh. C-type lectin receptors (CLR) ditandai dengan domain pengikat nukleotida dan
kaya leusin yang dapat mendeteksi sinyal intraseluler melalui berbagai jenis domain sitoplasma. CLR adalah keluarga PRR yang mengikat glikan melalui pengenalan karbohidrat ekstraseluler dan memediasi sinyal intraseluler melalui berbagai jenis domain seluler, yang mengakibatkan penurunan neutrofil dan memfasilitasi terjadinya infeksi jamur. Studi ini meninjau faktor penentu genetik mekanisme pertahanan dan defisiensi imun terhadap infeksi Candida.
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Hak Cipta (c) 2025 Adelia Wuri Pramudita, Harijono Kariosentono, Annisa Marsha Evanti, Zilpa Widyastuti
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