Comparison of Efficacy and Safety of Inactivated Influenza Vaccine and Deadly Influenza Vaccine in Children with Asthma: A Systematic Review and Meta-Analysis
Analysis
DOI:
https://doi.org/10.55175/cdk.v52i6.1666Keywords:
Asthma, influenza, IIV, LAIVAbstract
Introduction: Asthma patients are at higher risk of experiencing respiratory morbidity due to influenza, vaccination is recommended for this group. This study aims to compare the efficacy and side effects between live-attenuated influenza vaccines (LAIV) and inactivated influenza vaccines (IIV) in asthmatic children. Methods: This research use PRISMA guidelines, with studies sourced from PubMed, Cochrane, and Embase. ROB2 and ROBINS were employed to assess the risk of bias. Quantitative analysis was performed using Review Manager v5.4. Results: A total of 4,753 samples were collected, consisting of 2,390 intervention patients and 2,363 control patients. The meta-analysis results showed that influenza infection was more likely to occur in patients who received the inactivated influenza vaccine [pooled OR = 0.58; 95% CI (0.43, 0.78)}. Conclusion: The recommended vaccine type is the live-attenuated influenza vaccine, as no significant differences in side effects were observed between the two vaccines.
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Copyright (c) 2025 Arohid Allatib, S.Ked, dr. Handre Putra, Sp.A, Mahfudz Shidiq, S.Ked, Pedro Markus Sanggara Purba, S.Ked, Etheldreda Oleshya Keylavan Wibowo Viera
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