Perbandingan Efikasi dan Keamanan Vaksin Influenza yang Dilemahkan dan Vaksin Influenza yang Dimatikan pada Anak dengan Asma: Tinjauan Sistematis dan Meta-Analisis
Analisis
DOI:
https://doi.org/10.55175/cdk.v52i6.1666Kata Kunci:
Asma, influenza, IIV, LAIVAbstrak
Pendahuluan: Pasien asma memiliki risiko lebih tinggi mengalami morbiditas pernapasan akibat influenza sehingga direkomendasikan menjalani vaksinasi. Penelitian ini membandingkan efikasi dan efek samping antara vaksinasi virus influenza yang dilemahkan (LAIV) dan vaksinasi influenza yang dimatikan (IIV) pada anak dengan asma. Metode: Penelitian ini mengikuti panduan PRISMA, studi yang dianalisis berasal dari PubMed, Cochrane, dan Embase. Kami juga menggunakan ROB2 serta ROBINS untuk penilaian risiko bias. Analisis kuantitatif menggunakan Review Manager v5.4. Hasil: Terkumpul total 4.753 sampel, dengan 2.390 pasien intervensi dan 2.363 pasien kontrol. Hasil meta-analisis menunjukkan kejadian terkena influenza cenderung pada pasien dengan vaksinasi influenza yang dimatikan [pooled OR = 0,58; 95% CI (0,43, 0,78). Simpulan: Jenis vaksin yang disarankan adalah vaksin influenza yang dilemahkan; efek samping antara kedua jenis vaksin tidak berbeda bermakna.
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Referensi
Trombetta CM, Kistner O, Montomoli E, Viviani S, Marchi S. Influenza viruses and vaccines: The role of vaccine effectiveness studies for evaluation of the benefits of influenza vaccines. Vaccines. 2022;10(5):714. DOI: 10.3390/vaccines10050714.
Nayak J, Hoy G, Gordon A. Influenza in children. Cold Spring Harb Perspect Med. 2021;11(1): a038430. DOI: 10.1101/cshperspect.a038430.
Xie LY, Wang T, Yu T, Hu X, Yang L, Zhong LL, et al. Seasonality of respiratory syncytial virus infection in children hospitalized with acute lower respiratory tract infections in Hunan, China, 2013–2022. Virol J. 2024;21(1):62. DOI: 10.1186/s12985-024-02336-8.
Yaneva M, Darlenski R. The link between atopic dermatitis and asthma- Immunological imbalance and beyond. Asthma Res Pract. 2021;7(1):16. DOI: 10.1186/s40733-021-00082-0.
Seidenari S, Giusti F. Atopy. Irrit Dermat [Internet]. 2006 Jun 8 [cited 2024 Nov 24]:185–97. https://www.ncbi.nlm.nih.gov/books/NBK542187/.
Li KH, Leong PY, Tseng CF, Wang YH, Wei JCC. Influenza vaccination is associated with lower incidental asthma risk in patients with atopic dermatitis: A nationwide cohort study. Front Immunol. 2021;12:729501. DOI: 10.3389/fimmu.2021.729501.
Macias AE, McElhaney JE, Chaves SS, Nealon J, Nunes MC, Samson SI, et al. The disease burden of influenza beyond respiratory illness. Vaccine 2021;39(Suppl 1):A6–14. DOI: 10.1016/j.vaccine.2020.09.048.
Merckx J, Ducherme FM, Martineau C, Zemek R, Gravel J, Chalut D, et al. Respiratory viruses and treatment failure in children with asthma exacerbation. Pediatrics 2018;142(1):e20174105. DOI: 10.1542/peds.2017-4105.
Sridhar S, Brokstad K, Cox R. Influenza vaccination strategies: Comparing inactivated and live attenuated influenza vaccines. Vaccines 2015;3(2):373–89. DOI: 10.3390/vaccines3020373.
Gwiharto AK, Suhandi C, Alodya C, Sinurya RK. Studi efektivitas vaksin influenza: Updated review. Keluwih J Kesehat dan Kedokt. 2021;3(1):48–56. DOI: 10.24123/kesdok.V3i1.4063.
Committee I of M (US) ISR, Stratton K, Alamario DA, Wizemann T, McCormick MC. Immunization safety review: Influenza vaccines and neurological complications. 2004 [cited 2024 Nov 1]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK222009/.
Turner PJ, Fleming L, Saglani S, Southern J, Andrews NJ, Miller E, et al. Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma. J Allergy Clin Immunol. 2020;145(4):1157-1164.e6. DOI: 10.1016/j.jaci.2019.12.010.
Sokolow AG, Stallings AP, Kercsmar C, Harrington T, Jimenez-Truque N, Zhu Y, et al. Safety of live attenuated influenza vaccine in children with asthma. Pediatrics 2022;149(4): e2021055432. DOI: 10.1542/peds.2021-055432.
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. Cochrane Training [Internet]. Cochrane. 2019 [cited 2024 Nov 24]. Available from: https://training.cochrane.org/handbook/current.
Fleming DM, Crovari P, Wahn U, Klemola T, Schlesinger Y, Langussis A, et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J. 2006;25(10):860–9. DOI: 10.1097/01.inf.0000237797.14283.cf.
Krammer F, Palese P. Advances in the development of influenza virus vaccines. Nat Rev Drug Discov. 2015;14(3):167–82. DOI: 10.1038/nrd4529.
Ashkenazi S, Vertruyen A, Arístegui J, Esposito S, McKeith DD, Klemola T, et al. Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J. 2006;25(10):870–9. DOI: 10.1097/01.inf.0000237829.66310.85.
Ambrose CS, Dubovsky F, Yi T, Belshe RB, Ashkenazi S. The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezing. Eur J Clin Microbiol Infect Dis. 2012;31(10):2549-57. DOI: 10.1007/s10096-012-1595-9.
Edwards K. Influenza vaccine feasibility study in children with persistent asthma-Clinical trials. Vanderbilt University Medical Center [Internet]. 2018. Available from: https://trial.medpath.com/clinical-trial/d8ec2a362ea5e6a8/nct02967393-safety-influenza-vaccine-children-asthma.
Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med. 2007;356(7):685–96. DOI: 10.1056/NEJMoa065368.
Chung JR, Flannery B, Ambrose CS, Begue RE, Caspard H, DeMarcus L, et al. Live attenuated and inactivated influenza vaccine effectiveness. Pediatrics 2019;143(2):e20182094. DOI: 10.1542/peds.2018-2094.
Subbramanian RA, Basha S, Shata MT, Brady RC, Bernstein DI. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine 2010;28(52):8258–67. DOI: 10.1016/j.vaccine.2010.10.077.
He XS, Holmes TH, Zhang C, Mahmood K, Kemble GW, Lewis DB, et al. Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines. J Virol. 2006;80(23):11756–66. DOI: 10.1128/JVI.01460-06.
Spitaels J, Roose K, Saelens X. Influenza and memory t cells: How to awake the force. vaccines. 2016;4(4):33. DOI: 10.3390/vaccines4040033.
Hoft DF, Lottenbach KR, Blazevic A, Turan A, Blevins TP, Pacatte TP, et al. Comparisons of the humoral and cellular immune responses induced by live attenuated influenza vaccine and inactivated influenza vaccine in adults. Clin Vaccine Immunol. 2017;24(1). DOI: 10.1128/CVI.00414-16.
Clemens E, Van de Sandt C, Wong S, Wakim L, Valkenburg S. Harnessing the power of t cells: The promising hope for a universal influenza vaccine. Vaccines 2018;6(2):18. DOI: 10.3390/vaccines6020018.
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Hak Cipta (c) 2025 Arohid Allatib, S.Ked, dr. Handre Putra, Sp.A, Mahfudz Shidiq, S.Ked, Pedro Markus Sanggara Purba, S.Ked, Etheldreda Oleshya Keylavan Wibowo Viera
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