Diagnosis dan Tatalaksana Irritable Bowel Syndrome
DOI:
https://doi.org/10.55175/cdk.v46i12.393Keywords:
Diagnosis, irritable bowel syndrome, tatalaksanaAbstract
Irritable Bowel Syndrome (IBS) merupakan penyakit dengan prevalensi global mencapai 11%. Gejala IBS yang tidak spesifik dan serupa penyakit saluran pencernaan lain menyulitkan diagnosis sehingga banyak pemeriksaan penunjang yang sebenarnya tidak perlu dilakukan. Diagnosis IBS ditegakkan berdasarkan kriteria Rome IV. Patofisiologi IBS belum sepenuhnya dipahami dan terapi lebih bersifat simptomatik sesuai subtipe IBS dan gejala yang mendominasi, terdiri dari terapi non-farmakologi dan farmakologi. Beberapa terapi farmakologi baru mulai dikembangkan.
Irritable Bowel Syndrome (IBS) affects around 11% global population. Non-specific symptoms of IBS and similarities with other gastrointestinal disorder cause difficulties in diagnosis and excessive diagnostic tests. Diagnosis is according to Rome IV criteria. The pathophysiology of IBS is not yet fully understood and most of the existing therapies are symptomatic according to subtype and the predominant symptoms, consisting of non-pharmacological and pharmacological therapies. Some new pharmacological therapies are being developed.
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Lacy BE, Mearin F, Chang L, Chey WD, Lembo AJ, Simren M, et al. Bowel disorders. Gastroenterology [Internet]. 2016 May 1 [cited 2018 Oct 15];150(6):1393–407.e5. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0016508516002225
Ford AC, Lacy BE, Talley NJ. Irritable bowel syndrome. Longo DL, editor. N Engl J Med [Internet]. 2017 Jun 29 [cited 2018 Oct 15];376(26):2566–78. Available from: http://www.nejm.org/doi/10.1056/NEJMra1607547
Canavan C, West J, Card T. The epidemiology of irritable bowel syndrome. Clin Epidemiol [Internet]. 2014 [cited 2018 May 5];6:71–80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24523597
Lacy BE, Chey WD, Lembo AJ. New and emerging treatment options for irritable bowel syndrome. Gastroenterol Hepatol (N Y) [Internet]. 2015 Apr [cited 2018 May 5];11(4Suppl2):1–19. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26491416
Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome. JAMA [Internet]. 2015 Mar 3 [cited 2018 May 5];313(9):949. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2015.0954
Sayuk GS, Gyawali CP. Irritable bowel syndrome: Modern concepts and management options. Am J Med [Internet]. 2015 Aug 1 [cited 2019 May 15];128(8):817–27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25731138
Palsson OS, Whitehead WE, van Tilburg MAL, Chang L, Chey W, Crowell MD, et al. Development and validation of the Rome IV diagnostic questionnaire for adults. Gastroenterology [Internet]. 2016 May 1 [cited 2018 Oct 16];150(6):1481–91. Available from: https://www.sciencedirect.com/science/article/pii/S0016508516001803
Chumpitazi BP, Self MM, Czyzewski DI, Cejka S, Swank PR, Shulman RJ. Bristol stool form scale reliability and agreement decreases when determining Rome III stool form designations. Neurogastroenterol Motil [Internet]. 2016 Mar [cited 2018 Oct 15];28(3):443–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26690980
Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA, American College of Gastroenterology. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol [Internet]. 2013 May [cited 2019 May 15];108(5):656–76; quiz 677. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23609613
Irvine AJ, Chey WD, Ford AC. Screening for celiac disease in irritable bowel syndrome: An updated systematic review and meta-analysis. Am J Gastroenterol [Internet]. 2017 Jan [cited 2019 May 15];112(1):65–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27753436
Ford AC, Moayyedi P, Chey WD, Harris LA, Lacy BE, Saito YA, et al. American College of gastroenterology monograph on management of irritable bowel syndrome. Am J Gastroenterol [Internet]. 2018 Jun [cited 2019 Feb 25];113(Suppl 2):1–18. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29950604
Böhn L, Störsrud S, Liljebo T, Collin L, Lindfors P, Törnblom H, et al. Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: A randomized controlled trial. Gastroenterology [Internet]. 2015 Nov [cited 2019 May 15];149(6):1399–1407.e2. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26255043
Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology [Internet]. 2014 Jan [cited 2019 May 15];146(1):67–75.e5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24076059
Eswaran SL, Chey WD, Han-Markey T, Ball S, Jackson K. A randomized controlled trial comparing the low FODMAP diet vs. modified NICE guidelines in US adults with IBS-D. Am J Gastroenterol [Internet]. 2016 Dec [cited 2019 May 15];111(12):1824–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27725652
Simrén M, Törnblom H, Palsson OS, Whitehead WE. Management of the multiple symptoms of irritable bowel syndrome. lancet Gastroenterol Hepatol [Internet]. 2017 Feb 1 [cited 2018 Oct 16];2(2):112–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28403981
Saha L. Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine. World J Gastroenterol [Internet]. 2014 Jun 14 [cited 2018 May 5];20(22):6759–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24944467
Lembo AJ, Lacy BE, Zuckerman MJ, Schey R, Dove LS, Andrae DA, et al. Eluxadoline for irritable bowel syndrome with diarrhea. N Engl J Med [Internet]. 2016 Jan 21 [cited 2019 Feb 15];374(3):242–53. Available from: http://www.nejm.org/doi/10.1056/NEJMoa1505180
Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome. JAMA [Internet]. 2015 Mar 3 [cited 2018 Oct 17];313(9):949. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2015.0954
Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, et al. Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther [Internet]. 2009 Feb 1 [cited 2019 May 15];29(3):329–41. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19006537
Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol [Internet]. 2015 Mar 14 [cited 2018 Oct 17];21(10):3072–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25780308
Moraes-Filho JP, Quigley EMM. The intestinal microbiota and the role of probiotics in irritable bowel syndrome: A review. Arq Gastroenterol [Internet]. 2015 Dec [cited 2019 May 15];52(4):331–8. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032015000400331&lng=en&tlng=en
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