Antibiotik Profilaksis pada Tindakan Bedah
DOI:
https://doi.org/10.55175/cdk.v46i12.398Keywords:
Antibiotik, bedah, profilaksisAbstract
Antibiotik profilaksis pra-operasi didefinisikan sebagai pemberian antibiotik sebelum operasi untuk mengurangi risiko infeksi pasca-operasi. Antibiotik profilaksis optimal untuk pembedahan idealnya sesuai pedoman penggunaan antibiotik profilaksis atau pedoman lokal. Kriteria antibiotik profilaksis dalam pembedahan yang tepat meliputi tepat indikasi, tepat jenis antibiotik, tepat dosis, tepat rute, tepat waktu, dan durasi pemberian.
Pre-operative antibiotic prophylaxis is defined as administration of antibiotics prior to surgical procedure to decrease postoperative infection risk. The optimal antibiotic prophylaxis for surgery is ideally in accordance with the guidelines. The key elements of appropriate surgical antimicrobial prophylaxis prescribing include correct indication, antimicrobial, drug dose, route, timing of administration, and duration.
Downloads
References
Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 2013;70(3):195-283. doi: 10.2146/ajhp120568.
Crader MF, Varacallo M. Preoperative antibiotic prophylaxis. Medscape [Internet] 2019 [cited 2019 August 8]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK442032/
Ierano C, Nankervis JM, James R, Rajkhowa A, Peel T, Thursky K. Surgical antimicrobial prophylaxis. Aust Prescr. 2017;40(6):225–9.
Peraturan Menteri Kesehatan Republik Indonesia Nomor 8 Tahun 2015 Tentang Program Pengendalian Resistensi Antibiotik Di Rumah Sakit. [Internet] 2015 [cited 2019 August 8]. Available from: https://ghsaindonesia.files.wordpress.com/2016/02/peraturan-menteri-kesehatan-ri-no-8-tahun-2015-tentang-pengendalianresistensi-antibiotik -di-rumah-sakit.pdf
Tarchini G, Liau KH, Solomkin JS. Antimicrobial stewardship in surgery: Challenges and opportunities. Clin Infect Dis. 2017;64(suppl2):112-4
eTG complete [Internet]. 2017 [cited 2019 August 8]. Available from: www.tg.org.au
Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Healthcare infection control practices advisory Committee Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152:784-91.
National Institute for Health and Care Excellence. Surgical site infections: Prevention and treatment. Clinical guideline 74. London: NICE; 2008. [Internet] 2017 [Cited 2019 August 8]. Available from: www.nice.org.uk/guidance/cg74
Heal CF, Buettner PG, Drobetz H. Risk factors for surgical site infection after dermatological surgery. Int J Dermatol. 2012;51:796-803.
Smith SC, Heal CF, Buttner PG. Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: A prospective randomised placebo-controlled double-blind trial. BMJ Open 2014;4:e005270.
Scottish Intercollegiate Guidelines Network. Antibiotic prophylaxis in surgery. SIGN 104. Edinburgh: SIGN; 2008. [Internet]. 2014 [cited 2019 August 8]. Available from: http://www.sign.ac.uk/sign-104-antibiotic-prophylaxis-in-surgery.html
Unger NR, Stein BJ. Effectiveness of pre-operative cefazolin in obese patients. Surg Infect (Larchmt) 2014;15:412-6.
Ho VP, Nicolau DP, Dakin GF, Pomp A, Rich BS, Towe CW, et al. Cefazolin dosing for surgical prophylaxis in morbidly obese patients. Surg Infect (Larchmt) 2012;13:33-7.
Allegranzi B, Bischoff P, de Jonge S, Kubilay NZ, Zayed B, Gomes SM, et al. WHO Guidelines Development Group New WHO recommendations on preoperative measures for surgical site infection prevention: An evidence-based global perspective. Lancet Infect Dis. 2016;16:276-87.
Duffield A, Sultan P, Riley ET, Carvalho B. Optimal administration of cefazolin prophylaxis for cesarean delivery. J Perinatol. 2017;37:16-20.
Mackeen AD, Packard RE, Ota E, Berghella V, Baxter JK. Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. Cochrane Database Syst Rev. 2014;(12):CD009516.
Lador A, Nasir H, Mansur N, Sharoni E, Biderman P, Leibovici L, et al. Antibiotic prophylaxis in cardiac surgery: Systematic review and meta-analysis. J Antimicrob Chemother. 2012;67:541-50.
Mertz D, Johnstone J, Loeb M. Does duration of perioperative antibiotic prophylaxis matter in cardiac surgery? A systematic review and meta-analysis. Ann Surg. 2011;254:48-54.
McIntosh J, Earnshaw JJ. Antibiotic prophylaxis for the prevention of infection after major limb amputation. Eur J Vasc Endovasc Surg. 2009;37:696-703.
Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Association of adverse events with antibiotic use in hospitalized patients. JAMA Intern Med. 2017;177:1308-15.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
