Malondialdehid sebagai Penanda Stres Oksidatif pada Berbagai Penyakit Kulit
DOI:
https://doi.org/10.55175/cdk.v47i1.13Keywords:
Malondialdehid, penyakit kulit, stres oksidatif, Malondialdehyde, oxidative stress, skin diseasesAbstract
Kulit merupakan sistem pertahanan pertama tubuh. Lapisan kulit menjadi pelindung organ dalam dari paparan luar baik kimia maupun berbagai polutan dan racun. Paparan tersebut akan menyebabkan kondisi kulit rentan terkena stres oksidatif. Kondisi stres oksidatif yang terus-menerus dapat menjadi faktor risiko atau memperparah penyakit kulit. Malondialdehid (MDA) merupakan produk sekunder peroksidasi lipid pada kondisi stres oksidatif. Berbagai laporan penelitian menunjukkan kadar malondialdehid berbeda signifikan pada beberapa penyakit kulit seperti akne vulgaris, dermatitis atopi, melasma, psoriasis, dan vitiligo jika dibandingkan kontrol. Nilai MDA juga berbanding lurus dengan derajat keparahan penyakit-penyakit kulit tersebut.
Skin is the first defense system in the body. The skin layer provides protection from oxidative stress due to external chemical exposure and various pollutants and poisons. Persistent oxidative stress can be a risk factor for skin disorders. Malondialdehyde (MDA) is a secondary product of lipid peroxidation under oxidative stress. Various researches show that the level of malondialdehyde differs significantly in some skin diseases such as acne vulgaris, atopic dermatitis, melasma, psoriasis, and vitiligo as compared with controls. MDA value is also directly proportional to the severity of skin diseases.
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