The Effect of Red Dragon Fruit (Hylocereus Polyrhizus) Extract on HDL Levels in Wistar Rats of Metabolic Syndrome Model
Research
DOI:
https://doi.org/10.55175/cdk.v51i10.1145Keywords:
Dragon fruit, HDL, Hylocereus polyrhizus, metabolic syndromeAbstract
Introduction: Metabolic syndrome is characterized by hypertension, central obesity, insulin resistance, and dyslipidemia. Hylocereus polyrhizus is known for its potential in treating metabolic syndrome. Method: Laboratory experimental study with pretest-posttest control group design. Thirty rats were divided into 5 groups: K1 and K2 as negative and positive control, K3, K4, and K5 as groups receiving red dragon fruit extract at doses of 60, 120, and 180 mg/200 gBW. Data were analyzed using one-way ANOVA, Tukey HSD test, paired T-test, and Pearson correlation. Results: The highest HDL levels were observed in K5, while the lowest was in K1. Pearson correlation revealed a strong relationship between the dose of Hylocereus polyrhizus and HDL levels. Conclusion: Hylocereus polyrhizus extract could significantly increase HDL level. In this study, the optimal dose was 180 mg/200 gBW.
Downloads
References
WHO. HIV [Internet]. 2022 [cited 2023 Mar 19]. Available from: https://www.who.int/data/gho/data/themes/hiv-aids#:~:text=Global situation and trends%3A,at the end of 2021.
Nalwanga D, Musiime V. Children living with HIV: A narrative review of recent advances in pediatric HIV research and their implications for clinical practice. Ther Adv Infect Dis. 2022;9:20499361221077544. DOI: 10.1177/20499361221077544.
Sibuea F, Hardhana B, Widiantini W. Profil kesehatan Indonesia tahun 2021. Jakarta: Kementrian Kesehatan Republik Indonesia; 2022.
Bali Ministry of Health. Profil kesehatan Bali tahun 2021 [Internet]. 2022. Available from: ttps://diskes.baliprov.go.id/download/profil-kesehatanprovinsi-bali-2021/.
Intiful FD, Abdulai H, Nyarko R, Tette E, Asante M. Malnutrition in HIV infected children on antiretroviral drugs in a cohort of Ghanaian children [Internet]. 2021 [cited 2023 May 5]. Available from: https://www.cell.com/heliyon/fulltext/S2405-8440(21)02739-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844021027390%3Fshowall%3Dtrue.
Duggal S, Chugh TD, Duggal AK. HIV and malnutrition: Effects on immune system [Internet]. 2012 [cited 2023 May 5]. Available from: https://onlinelibrary.wiley.com/doi/10.1155/2012/784740.
Lodha R, Kabra SK. Health & nutritional status of HIV infected children. Indian J Med Res. 2015;141(1):10–2. DOI: 10.4103/0971-5916.154494.
Dahlan MS. Besar sampel dalam penelitian kedokteran dan kesehatan. Jakarta: Epidemiologi Jakarta; 2020.
Omoni AO, Christian P, Sadoh WE, Okechukwu AA, Olateju EK, Omoigberale AI, et al. Immunologic outcomes of antiretroviral therapy among hivinfected nigerian children and its association with early infant feeding and nutritional status at treatment initiation. The Pediatric Infectious Disease Journal 2013;32(7):e291–7. DOI: 10.1097/INF.0b013e31828b2a2f.
Hampl SE, Hassink SG, Skinner AC, Armstrong SC, Barlow SE, Bolling CF, et al. Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity. Pediatrics 2023;151(2):e2022060640. DOI: 10.1542/peds.2022-060640.
Rolland-Cachera MF, Deheeger M, Bellisle F, Sempé M, Guilloud-Bataille M, Patois E. Adiposity rebound in children: A simple indicator for predicting obesity. The American Journal of Clinical Nutrition 1984 Jan 1;39(1):129–35. DOI: 10.1093/ajcn/39.1.129.
Matin S, Veria V, S1 P, Masyarakat K, Kesehatan F, Nuswantoro D, et al. Body mass index (BMI) sebagai salah satu faktor yang berkontribusi terhadap prestasi belajar remaja (studi pada mahasiswa Fakultas Kesehatan Universitas Dian Nuswantoro). Jurnal Kesehatan Masyarakat 2013 Des;12(2):163-69. DOI: 10.33633/visikes.v12i2.649.
Kurniati N. Pedoman penerapan terapi HIV pada anak. Jakarta: Indonesian Ministry of Health; 2014.
Naidoo R, Rennert W, Lung A, Naidoo K, McKerrow N. The influence of nutritional status on the response to HAART in HIV-infected children in South Africa. Pediatr Infect Dis J. 2010;29(6):511-3. DOI: 10.1097/INF.0b013e3181d1e989.
Aaradhana S, Ravi S, Vishnu M, Divya J, Kriti M. The effect of nutritional status on the response to highly active antiretroviral therapy in human immunodeficiency virus-infected children at regional antiretroviral therapy centre in Northern India. Indian J Child Health 2018;05(02):95–8. DOI: 10.32677/IJCH.2018.v05.i02.006.
Ebissa G, Deyessa N, Biadgilign S. Impact of highly active antiretroviral therapy on nutritional and immunologic status in HIV-infected children in the low-income country of Ethiopia. Nutrition 2016;32(6):667–73. DOI: 10.1016/j.nut.2015.12.035.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Valensia Putri Melliana, Jarot Subandono, Danus Hermawan, R. Prihandjojo Andri Putranto, Sarsono
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
