Penggunaan Vitamin D3 Oral Dosis Tinggi
DOI:
https://doi.org/10.55175/cdk.v49i10.1718Keywords:
High dose vitamin D, oral vitamin D3Abstract
Vitamin D is a fat-soluble vitamin with an important role in various skeletal and non-skeletal physiological functions. Vitamin D deficiency has been found in many countries including Indonesia, and has been associated with an increased risk of various diseases. Vitamin D supplementation or even high-dose vitamin D therapy is often necessary to maintain or to achieve optimal vitamin D status, especially if rapid correction is required and/or as adjunctive therapy for other diseases. Various clinical trials have shown that high-dose oral vitamin D3 therapy is effective and relatively safe for vitamin D deficiency patients.
Downloads
References
Shuler FD, Lycans D, Salloum E. Extraskeletal effects of Vitamin D: Potential impact on WV disease morbidity and mortality. W V Med J. 2012;108(3):56-62.
Sizar O, Khare S, Goyal A, Givler A. Vitamin D deficiency [Internet]. 2022 [cited 2022 Jun 08]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532266/
Vitamin D [Internet]. 2019 [cited 2022 Apr 15]. Available from: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/?print=1
Lappe JM. The role of vitamin D in human health: A paradigm shift. J Evidence-Based Complementary Alternative Med 2011;16(1):58-72.
Smith EM, Tangpricha V. Driving up the dose: Implications for high-dose vitamin D therapy. Endocr Pract. 2015;21(10):1178-80.
Gorman S, Lucas RM, Aallen-Hall A, Fleury N, Feelisch N. et al. Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. Photochem Photobiol Sci.2017;16:362-73. Doi: 10.1039/c6pp00274a
Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol.2008;3:1535-41. Doi: 10.2215/CJN.01160308
Armas LAG, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrin Metab 89(11):5387-91.
Telessy IG. Vitamin D-too little, or too much in the elderly and the obese? Open Acc J Bio Sci. 2020;2(4):415-20.
Nimitphong H, Park E, Lee M. Vitamin D regulation of adipogenesis and adipose tissue functions. Nutr Res Pract. 2020;14(6):553-67. Doi: 10.4162/nrp.2020.14.6.553.
Lockau L, Atkinson SA. Vitamin D’s role in health and disease: How does the present inform our understanding of the past? Int J Paleopathol. 2018;23:6-14. Doi: 10.1016/j.ijpp.2017.11.005.
Calcitriol [Internet]. 2022 [cited 2022 June 06]. Available from: https://vitamindwiki.com/Calcitriol
Peraturan Menteri Kesehatan Republik Indonesia nomor 28 tahun 2019 tentang angka kecukupan gizi yang dianjurkan untuk masyarakat Indonesia [Internet]. 2019 [cited 2020 Feb 6]. Available from: http://hukor.kemkes.go.id/uploads/produk_hukum/PMK_No__28_Th_2019_ttg_Angka_Kecukupan_Gizi_Yang_Dianjurkan_
Untuk_Masyarakat_Indonesia.pdf
Jacobsen RB, Hronek BW, Schmidt GA, Schilling ML. Hypervitaminosis D associated with a vitamin D dispensing error. Ann Pharmacother. 2011;45(10):e52. Doi: 10.1345/aph.1Q330
Yati NP, Batubara JRL, Suryawan IWB. Vitamin D: Panduan praktis klinis Ikatan Dokter Anak Indonesia. Jakarta: Badan Penerbit Ikatan Dokter Anak Indonesia. 2018.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab.2011;96(7):1911-30.
Oemardi M, Horowitz M, Wishart JM, Morris HA, Need AG, O’Loughlin PD, et al. The effect of menopause on bone mineral density and bone-related biochemical variables in Indonesian women. Clin Endocrinol (Oxf). 2007;67(1):93-100.
Setiati S, Oemardi M, Sutrisna B. The role of ultraviolet-B from sun exposure on vitamin D3 and parathyroid hormone level in elderly women in Indonesia. Asian J Gerontol Geriatr. 2007;2(3):126-32.
Green TJ, Skeaff CM, Rockell JEP, et al. Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur. Eur J Clin Nutr.2008;62(3):373-8.
Soesanti F, Pulungan A, Tridjaja B, Batubara JRL. Vitamin D profile in healthy children aged 7-12 years old in Indonesia. Int J Pediatr Endocrinol. 2013,(Suppl 1):167-71.
Khan QJ, Fabian CJ, Fabian CJ. How I treat vitamin D deficiency. J Oncol Pract. 2010;6(2):97-101.
Gani LU, How CH. Vitamin D deficiency. Singapore Med J 2015;56(8):433-7.
Billoo AG, Murtaza G, Memon MA, Khaskheli SA, Iqbal K. Comparison of oral versus injectable vitamin-D for the treatment of nutritional vitamin-D deficiency rickets. J Coll Physicians Surg Pak.2009;19(7):428-31.
Zabihiyeganeh M, Jahed A, Nojomi M. Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT. Clin Endocrinol (Oxf) 2013;78(2):210-6.
Lemieu P, Weisnagel SJ, Caron AZ, Julien A, Morisset A, Carreau A. Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: A randomised, placebo-controlled trial. Eur J Endocrinol. 2019;181(3):287-99.
Pinzon RT, Wijaya VO, Veronica V. The benefits of add-on therapy of vitamin D 5000 IU to the vitamin D levels and symptoms in diabetic neuropathy patients: A randomized clinical trial. J Pain Res. 2021;14:3865-75.
Sanchez-Armendariz K, Garcia-Gil A, Contreras-Ruiz J, Karam-Orante M, Balcazar-Antonio D, Dominguez-Cherit J. Oral vitamin D3 5000 IU/day as an adjuvant in the treatment of atopic dermatitis: a randomized control trial. Int J Dermatol.2018;57(12):1516-20.
Sabico S, Enani MA, Sheshah E, Aljohani NJ, Aldisi DA, Alotaibi NH, et al. Effects of a 2-week 5000 IU versus 1000 IU vitamin D3 supplementation on recovery of symptoms in patients with mild to moderate Covid-19: A randomized clinical trial. Nutrients 2021;13(2170).
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and covid-19 infection and deaths. Nutrients 2020;12:988.
Nursyam EW, Amin Z, Rumende CM. The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med Indones-Indones J Intern Med 2006;38(1).
Torres M, Casado G, Vigon L, Rodriguez-Mora S, Mateos E, Ramos-Martin F, et al. Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D. Biomed Pharmacother. 2022;150:112965.
Moretti HD, Colucci VJ, Berry BD. Vitamin D3 repletion versus placebo as adjunctive treatment of heart failure patient quality of life and hormonal indices: A randomized, double-blind, placebo controlled trial. BMC Cardiovasc Disord. 2017;17:274.
Vidal M, Lane NE. The importance of vitamin D. Rheumatol Orthop Med 2020;5;6-9.
Wimalawansa SJ. Effective and practical ways to overcome vitamin D deficiency. J Family Med Community Health 2021;8(1):1185.
Talaei A, Mohamadi M, Adgi Z. The effect of vitamin D on insulin resistance in patients with type 2 diabetes. Diabetol Metab Syndr.2013,5:8.
Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al Mohamedy H. Prospective evaluation of the effect of short-term oral vitamin D supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med Princ Pract.2015;24(3):250-6.
Mottaghi T, Askari G, Khorvash F, Maracy MR. Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients. J Res Med Sci 2015;20:477-82.
Heidari B, Javadian Y, Babaei M, Yousef B. Restorative effect of vitamin D deficiency on knee pain and quadriceps muscle strength in knee osteoarthritis. Acta Med Iran 2015;53(8):466-70.
Bakhshaee M, Sharifian M, Esmatinia F, Rasoulian B, Mohebbi M. Therapeutic effect of vitamin D supplementation on allergic rhinitis. Eur Arch Otorhinolaryngol.2019;276(10):2797-801.
Iqbal K, Farooq S, Shoaib M. Efficacy of vitamin D in asthma. WJPMR 2018;4(5):323-5.
McCullough PJ, Lehrera DS, Amend J. Daily oral dosing of vitamin D3 using 5000 to 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J Steroid Biochem Mol Biol 2019;89:228-39.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
