Tinjauan atas Stevens-Johnson Syndrome dan Toxic Epidermal Necrolysis
DOI:
https://doi.org/10.55175/cdk.v46i7.461Keywords:
Hipersensitivitas, reaksi alergi obat, Stevens-Johnson syndrome, toxic epidermal necrolysisAbstract
Stevens-Johnson Syndrome dan toxic epidermal necrolysis (SJS/TEN) merupakan kasus jarang dengan kejadian 1-10 kasus per 1 juta kasus per tahun tetapi potensial mengancam nyawa. Etiologi tersering adalah reaksi hipersensitivitas terhadap obat. Patogenesis SJS/TEN belum sepenuhnya dimengerti. Gejala prodromal flu like symptom diikuti timbulnya bula dan epidermolisis. Komplikasi tersering adalah hipo- dan hiperpigementasi kulit serta pada mata. Tatalaksana terbaik adalah menghentikan obat yang disangka pencetus, terapi suportif berupa penggantian cairan dan elektrolit, terapi sistemik dan topikal, serta terapi untuk komplikasi pada mata.
Stevens-Johnson syndrome and toxic epidermal necrolysis ( SJS / TEN) is rare with an incidence of 1-10 cases per 1 million cases per year; but potentially life-threatening. The most common etiology is hypersensitivity reaction to drug. The symptoms begin with prodromal flu-like symptoms followed by the appearance of reddish lesions followed by bullae formation and epidermolysis. The most common complications are skin hypo- and hyperpigmentation and eye complications. The best management is to stop the presumptive drug, fluid and electrolye therapy and therapy for eye complications
Downloads
References
Valeyrie L, Claude J. Epidermal necrolysis (stevens-johnson syndrome and toxic epidermal necrolysis). In: Wolff K, Goldsmith LA, Katz SI,editors. Fitzpatrick’s dermatology in general medicine. 7th ed. New York: Mc Graw Hill; 2008. p.349-55
Djuanda A, Hamzah M. Sindrom stevens-johnson. Dalam: Djuanda A, Hamzah M, Aisah S,editors. Ilmu penyakit kulit dan kelamin. Edisi 6. Jakarta: Balai Penerbit Fakultas Kedokteran Indonesia; 2010. h.163-5
Anne S, Kosanam S, Prasanthi L. Stevens Johnson Syndrome and toxic epidermal necrolysis: a review. IJPR. 2014 Dec;4(4):158-165
Wong A, Malvestiti AA, Hafner M. Stevens Johnson Syndrome and toxic epidermal necrolysis: a review. Rev Assoc Med Brass. 2016 Aug;62(5):468-473
Harr T, French LE. Toxic epidermal necrolysis and Stevens Johnson Syndrome. Orphanet J Rare Dis. 2010 Dec 16;5(39):[16p]
Alerhand S, Casella C, Koyfman A. Stevens Johnson Syndrome and toxic epidermal necrolysis in the pediatric population. Pediatr Emer Care. 2016;32:472-8
Bohigian GM. The history of Stevens Johnson Syndrome and current management. Hist Ophthal Intern. 2015;1:87-9
Magana BR, Langner AL. Stevens Johnson Syndrome and toxic epidermal necrolysis in children: a literature review of current treatments. EMJ Dermatol. 2016;4(1):83-9
Yacoub MR, Berti A, Campochiaro C, et al. Drug induced exfoliative dermatitis: state of the arts. Clin Mol Allergy. 2016 ;4(9):13
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
