Terapi Sifilis Terkini
DOI:
https://doi.org/10.55175/cdk.v47i9.559Keywords:
Penyakit menular seksual, sifilis, terapiAbstract
Sifilis adalah penyakit menular seksual yang disebabkan oleh infeksi bakteri Treponema pallidum. Penularan sifilis biasanya melalui kontak seksual dengan pasangan terinfeksi, kontak langsung dengan lesi terinfeksi, transfusi, dan jarum suntik. Sifilis dapat disembuhkan pada tahap awal infeksi, tetapi apabila tidak mendapat pengobatan adekuat dapat menjadi infeksi sistemik dan berlanjut ke fase laten. Pengobatan sifilis yang efisien sangat penting untuk mengontrol sifilis secara efektif.
Syphilis is a sexually transmitted disease caused by a bacterial infection, Treponema pallidum. Transmission of syphilis is usually through sexual contact with an infected partner, direct contact with infected lesions, transfusions, and injection needles. Syphilis can be cured in the early stages of infection, but if it is not given adequate treatment it can become a systemic infection and progress to the latent phase. Efficient syphilis treatment is essential to control syphilis effectively
Downloads
References
Sparling PF, Morton NS, Daniel MM, Bernardine PH. Clinical manifestations of syphilis. In: Holmes KK, Sparling PF, Stamn WE, Piot P, Wasserhait JN, dkk, eds. Sexually transmitted disease. 4th Ed. New York: McGrow-Hill; 2008 .p. 661-84.
Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N, et al. Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One. 2015;10(12):9.
Center for Disease Control and Prevention. Sexually transmitted disease surveillance 2017 [Internet]. [cited 2018 Nov 1]. Available from: https://www.cdc.gov/std/stats17/default.htm.
Katz KA. Syphilis. In: Goldsmith Lowell A, Katz Stephen I, Gilchrest Barbara A, Paller Amy S, Leffell David J, Wolff Klaus, eds. Fitzpatrick dermatology in general medicine. 8th Ed. New York: McGraw-Hill; 2012 .p. 2469-92.
World Health Organization. WHO guidelines for the treatment of Treponema Pallidum (syphilis). Switzerland: World Health Organization; 2016 .p. 1-48.
Golden MR, Marra CM, Holmes KK. Update on Syphilis. JAMA. 2003;290(11):1510-4
Clement ME, Okeke L, Hicks CB. Treatment of syphilis. A systematic review. JAMA. 2014;312(8):1905-15.
Janier M, Hegyi V, Dupin N, Unemo M, Tiplica GS, Potocnik M. 2014 European guideline on the management of syphilis. JEADV. 2014;28:1581-93.
Workowski KA, Bolan G. Sexually transmitted diseases treatment guidelines 2015. CDC MWR Recommendations and Reports.2015;64(3):34-48.
Kingston M, French P, Higgins S, McQuillan O, Sukthankar A, Stott C, et al. UK National guidelines on the management of syphilis 2015. Int J STD AIDS.2015;27(6):421-6.
Kementrian Kesehatan Repuplik Indonesia. Pedoman nasional penanganan infeksi menular seksual. Jakarta: Kementrian Kesehatan Indonesia; 2016 .p. 27-8.
Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. MMWR. 2015;64(3):34-49.
Dayan L, Ooi C. Syphilis treatment: Old and new. Expert Opin Pharmacother. 2005;6(13):2271-80.
Djuanda A, Natahusada EC. Sifilis. In: Daili SF, Nilasari H, Indriatmi W, dkk, eds. Infeksi menular seksual. 5th Ed. Badan Penerbit FKUI: Jakarta; 2017.p.393.
Dinas Kesehatan Provinsi Jawa Tengah. Profil kesehatan Jawa Tengah 2017. Semarang: Dinas Kesehatan Provinsi Jawa Tengah; 2018 .p. 77.
Ho EL, Lukehart SA. Syphilis using modern approaches to understand an old disease. J of Clinical Invest. 2011;121(12):4584-92.
James WD, Berger TG, Elston DM. Syphilis, yaws, bejel, and pinta. In: Andrew’s disease of the skin clinical dermatology. 11th Ed. Canada: Elsevier; 2011 .p. 54-68.
Kinghorn GR, Omer R. Syphilis and congenital syphilis. In: Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D, Eds. Rook’s textbook of dermatology. 9th Ed. Blackwell Publishing: United Kingdom. 2016;29:3-35.
Workowski KA, Berman S. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines 2010. MMWR Recomm Rep. 2010;59(12):1-110.
Hawkes SJ, Gomez GB, Broutet N. Early antenatal care: Does it make a difference to outcomes of pregnancy associated with syphilis? A systematic review and metaanalysis. PLOS ONE. 2013;8(2):56713.
Hitti J, Watts DH. Bacterial sexually transmitted infections in pregnancy. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, dkk, Eds. Sexually transmitted diseases. 4th Ed. New York: McGraw-Hill; 2008.p.1542-55.
Rowawi R, Djayakusumah TS, Achdiat PA. Sifilis. In: Hidayati AN, Daili SF, Niode NJ, Indriatmi W, Budiono ES, Barakbah J, Eds. Manifestasi dan tatalaksana kelainan kulit dan kelamin pada pasien HIV/AIDS. Badan Penerbit FKUI:Jakarta; 2018 .p. 22-47.
Lewis DA, Lukehart SA. Antimicrobial resistance in Neisseria Gonorrhoeae and Treponema pallidum. Sex Transm Infect. 2011;87(suppl2):39-43.
Bicillin LA. Penicillin G benzathine: Dosing, indications, interactions, adverse effects and more [Internet]. [cited 2018 Nov 8]. Available from: https://reference.medscape.com/drug/bicillin-la-permapen-penicillin-g-benzathine-999573#0.
Riedner G, Rusizoka M, Todd J, Maboko L, Hoelscher M, Mmbando D, et al. Single-dose Azithromycin vs Penicillin G Benzathine for The Treatment of Early Syphilis. N Engl J Med.2005;353(12):1236-44.
Clement ME, Okeke NL, Hicks CB. Treatment of syphilis: A systematic review. JAMA. 2014;312(18):1905-17.
Ghanem KG, Erbelding EJ, Cheng WW, Rompalo AM. Doxycycline compared with benzathine penicillin for the treatment of early syphilis. Clin Infect Dis. 2006;42(6):45-9.
Psomas KC, Brun M, Causse A, Atoui N, Reynes J, Le Moing V. Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis. Médecine et maladies infectieuses. 2012;42(1):15-9.
Psomas KC, Brun M, Causse A, Atoui N, Reynes J, Le Moing V. Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis. Med Mal Infect. 2012;42(1):15-9.
Spornraft-Ragaller P, Abraham S, Lueck C, Meurer M. Response of HIV-infected patients with syphilis to therapy with penicillin or intravenous ceftriaxone. Eur J Med Res. 2011;16(2):47-51.
Pastuszczak M, Wojas-Pelc A. Current standards for diagnosis and treatment of syphilis: Selection of some practical issues, based on The European (IUSTI) and US (CDC) guidelines. Postep Derm Alergol. 2013;30(4):203.
Lukehart SA, Godornes C, Molini BJ, Sonnett P, Hopkins S, Mulcahy F, et al. Macrolide resistance in Treponema pallidum in the United States and Ireland.N Engl J Med. 2004;351(2):154-8.
Bai ZG, Wang B, Yang KH, Tian JH, Ma B, Liu YL, et al. Azithromycin vs benzathine penicillin G for early syphilis. Int J STD AIDS 2008;19(4):217-21.
Fredricks DN, Marrazzo JM. Azithromycin versus penicillin for early syphilis. Clin Microbiol Rev. 1996;9:18-33.
Chen XS, Yin YP, Wei WH, Wang HC, Peng RR, Zheng HP, et al. High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China. Clinical Microbiology and Infection. 2013;19(10):975-9.
Stamm LV. Global challenge of antibiotic-resistant Treponema pallidum. Antimicrobial agents and chemotherapy. 2010;54(2):583-9.
Ghanem KG. Neurosyphilis: A historical perspective and review. CNS Neurosci Ther. 2010;16(5):157-68.
Sato NS. Serologic response to treatment in syphilis. InTech. 2016:109-122.
Morshed MG. Current trend on syphilis diagnosis: Issues and challenges. Adv Exp Med Biol. 2014;808:51-64.
Rosana Y. Pemeriksaan laboratorium mikrobiologi infeksi menular seksual. In: Daili SF, Nilasari H, Indriatmi W, dkk, eds. Infeksi menular seksual. 5th Ed. Badan Penerbit FKUI: Jakarta; 2017 .p. 50-3.
Nayak S, Acharjya B. VDRL test and its interpretation. Indian J Dermatol Venereol. 2012;57(1):3.
Kementrian Kesehatan RI. Pedoman tata laksana sifilis untuk pengendalian sifilis di layanan kesehatan dasar Indonesia. Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. Jakarta: Kemenkes RI; 2013 .p. 21-3.
Knaute DF, Graf N, Lautenschlager S, Weber R, Bosshard PP. Serological response to treatment of syphilis according to disease stage and HIV status. Clin Infect Dis. 2012;55(12):1615-22.
Yang CJ, Lee NY, Lin YH, Lee HC, Ko WC, Liao CH, et al. Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the HIV infection epidemic. Clin Infect Dis. 2010;51(8):976-9
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
