Significance of Lewy Body Formation in Development of Parkinson’s Disease
DOI:
https://doi.org/10.55175/cdk.v45i8.736Keywords:
Alpha-synuclein, Lewy bodies, parkinsonAbstract
Parkinson’s disease is a serious neurodegenerative disease characterized by depletion of neurons in the substantia nigra of the basal ganglia. These dying out neurons are found to contain traces of Lewy bodies, an abnormal protein filament of alpha-synuclein and that otherwise play an important role in the nervous system, especially at synapses.
Penyakit Parkinson merupakan penyakit neurodegeneratif serius ditandai dengan deplesi neuron di substansia nigra ganglia basalis. Neuron ditemukan mengandung jejak Lewy Bodies, yang merupakan filamen protein abnormal alpha-synuclein
Downloads
References
Parkinson’s Disease Foundation. Statistics on Parkinson’s - Parkinson’s Disease Foundation (PDF) [Internet]. 2016 [cited 2016 December 5]. Available from: http://www.pdf.org/en/parkinson_statistics
Bear M, Connors B, Paradiso M. Neuroscience. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2007. p. 19, 467-8.
Fuller G, Manford, M. Neurology: An illustrated colour text. 3rd ed. Edinburgh: Churchill Livingstone/Elsevier; 2010. p. 2, 88-9
Jellinger K. Significance of brain lesions in Parkinson disease dementia and Lewy body dementia. Dementia In Clinical Practise 2009;24:1
Bergman H, Deuschl G. Pathophysiology of Parkinson’s disease: From clinical neurology to basic neuroscience and back. Movement Disord. 2002;17(3):28-9. http://dx.doi.org/10.1002/mds.10140
Galvan A, Wichmann T. Pathophysiology of Parkinsonism. Clin Neurophysiol. 2009;119(7):1459-61.
Adam D. The basal ganglia. KIN450-neurphysiology [Internet]. 2016 [cited 2016 December 5]. Available from: https://kin450-neurophysiology.wikispaces.com/Basal+Ganglia+II
Flanders Today. KU Leuven discovers brain process responsible for gripping [Internet]. 2015. Available from: http://www.flanderstoday.eu/innovation/ku-leuvendiscovers-brain-process-responsible-gripping.
Fix J, Brueckner J. High-yield Neuroanatomy. 4th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2009. p. 142-3
Brain structures and their functions. Serendip [Internet]. 2016 [cited 2016 December 6]. Available from: http://serendip.brynmawr.edu/bb/kinser/Structure1.html
National Parkinson Foundation. 10 early warning signs of Parkinson’s disease [Internet]. [cited 2016 December 6]. Available from: http://www.parkinson.org/understanding-parkinsons/10-early-warning-signs
Gut microbes promote motor deficits in a mouse model of Parkinson’s disease. ScienceDaily [Internet]. [cited 2016 December 6]. Available from: https://www.sciencedaily.com/releases/2016/12/161201122159.htm
National Institute on Aging. The basics of Lewy body dementia [Internet]. [cited 2016 December 6]. Available from: https://www.nia.nih.gov/alzheimers/publication/lewy-body-dementia/basics-lewy-body-dementia
Gibb W, Lees,A. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatr. 1988;51(6):745-50. http://dx.doi.org/10.1136/jnnp.51.6.745
Barker R, Parmar M, Kirkeby A, Björklund A, Thompson L, Brundin P. Are stem cell-based therapies for Parkinson’s disease ready for the clinic in 2016? IOS Press Content Library [Internet]. 2016. [cited December 6]. Available from : http://content.iospress.com/articles/journal-of-parkinsons-disease/jpd160798
Ian G. Mc.Keith N. Neuropsychopharmacology: The fifth generation of progress. Ch.91: Dementia with Lewy Bodies; 2002
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 https://creativecommons.org/licenses/by-nc/4.0/
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
