Modalitas Terapi Topikal Vitiligo

Authors

  • Rina Diana Departemen Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Univesitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta, Indonesia
  • Nurrachmat Mulianto Departemen Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran Univesitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta, Indonesia

DOI:

https://doi.org/10.55175/cdk.v45i7.750

Keywords:

Terapi topikal, vitiligo

Abstract

Vitiligo berpotensi menimbulkan dampak psikososial pada pasien, sehingga diperlukan terapi yang aman dan efektif. Saat ini belum ada terapi untuk menyembuhkan; tidak ada terapi tunggal yang dapat berhasil baik pada semua pasien, tetapi banyak pilihan untuk mengatasi lesi vitiligo. Modalitas terapi antara lain terapi topikal, terapi oral, terapi sinar, terapi bedah, terapi psikologis, dan terapi komplementer. Dengan meningkatnya penelitian dan pengetahuan tentang patomekanisme vitiligo, beberapa agen topikal baru dikembangkan untuk menginduksi pigmentasi.

 

Vitiligo has potential psychosocial impact on patients. There is currently no therapy to treat vitiligo, but many options are available to treat vitiligo lesions. No single therapy can produce good results in all patients; many treatment options are topical treatments, oral treatments, light therapy, surgical therapy, psychological therapy, and complementary therapies. Increasing research and knowledge on vitiligo patomechanism including relation with oxidative stress, skin blood flow, or a cytokine-mediated mechanisms neuropeptides lead to newly developed topical agents to induce pigmentation

Downloads

Download data is not yet available.

References

Alikhan A, Felsten LM, Daly M, Petronic-rosic V. Vitiligo: A comprehensive overview. J Am Dermatology. 2011;65(3):473–91.

Birlea SA, Spritz RA N DA. Vitiligo. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s dermatology in general medicine. 8th Ed. New York: The McGraw-Hill Companies; 2012. p. 792–803.

Anurogo D, Ikrar T. Vitiligo. CDK. 2014;41(9):666–75.

Gönül M, Cakmak SK, Oğuz D, Gül U, Kiliç S. Profile of vitiligo patients attending a training and research hospital in Central Anatolia: A retrospective study. J Dermatol. 2012;39(2):156–9.

Witasari D, Sukanto H, Setyaningrum T. Peningkatan kadar zink serum pada pasien vitiligo (increase of serum zinc levels in patients with vitiligo). Berk Ilmu Kesehatan Kulit dan Kelamin. 2016;28(3):1-8.

Diana R, Mulianto N. Profil pasien vitiligo di poliklinik kulit dan kelamin RSUD dr. Moewardi Surakarta periode Januari 2013 - Desember 2016. Surakarta; 2017.

Huriyah S, Rahardani IY, Danarti R. Pemilihan terapi nonbedah pada anak dengan vitiligo. MDVI. 2012;39(4):186–91.

Travis LB, Weinberg JM, Silverberg NB. Successful treatment of vitiligo with 0,1 % tacrolimus ointment. Arch Dermatol. 2014;139(5):571–4.

Nurhayati D. Uji banding efektivitas kalsipotriol topikal, suction blister grafting dan kombinasi keduanya pada terapi repigmentasi lesi vitiligo stabil. Media Med Indones. 2012;46(2):114–20

Whitton ME, Pinart M, Batchelor J, Leonardi-Bee J, González U, Jiyad Z, et al. Interventions for vitiligo (review). Cochrane Database Syst Rev. 2015;(2):1–308.

Malathi M, Thappa DM. Topical therapy in vitiligo: What is new? Pigment International 2016;3:1–4.

Garg BJ, Saraswat A, Bhatia A, Katare OP. Topical treatment in vitiligo and the potential uses of new drug delivery systems. Indian J Dermatol Venereol Leprol. 2010;76(3):231–8.

Bagherani N. Role of corticosteroids in treatment of vitiligo. In: State of the Art of Therapeutic Endocrinology. InTech; 2012. p. 187–224.

Gawkrodger DJ, Ormerod AD, Shaw L, Mauri-Sole I, Whitton ME, Watts MJ, et al. Vitiligo: Concise evidence based guidelines on diagnosis and management. Postgr Med J. 2010;86(1018):466–71.

Bleehen S. The treatment of vitiligo with topical corticosteroids. Light and electronmicroscopic studies. Br J Dermatol. 1976;94(suppl 1):43–50.

Ference JD, Last AR. Choosing topical corticosteroids. Am Fam Physician. 2009;79(2):135–40.

Masuria BL, Batra A, Kothiwala RK, Khuller R, Singhi MK. Topical mometasone furoate for the treatment of childhood vltiligo. Indian J Dermatol Venereol Leprol. 1999;65(5):219–21.

Shahmoradi Z, Mokhtari F, Faghihi G, Adibi N. Comparing the efficacy of topical clobetasol 0.05% plus 5-fluorouracil 5% cream vs. topical clobetasol 0.05% alone in treatment of vitiligo. J Res Med Sci. 2012;17(1 SPL.1):7–12.

Sisti A, Sisti G, Oranges CM. Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: A comprehensive literature review. An Bras Dermatol. 2016;91(2):187–95.

Hartmann A, Löhberg L, Keikavoussi P, Eichner S, Schuler G. Treatment of generalised vitiligo with tacrolimus 0.1% ointment vs. UVB intense pulsed light phototherapy: A pilot study. Acta Derm Venereol. 2014;94(5):585–7.

Valkova S, Trashlieva M, Christova P. Treatment of vitiligo with local khellin and UVA: Comparison with systemic PUVA. Clin Exp Dermatol. 2004;29(2):180–4.

Jain A, Mal J, Mehndiratta V, Chander R, Patra SK. Study of oxidative stress in vitiligo. Indian J Clin Biochem. 2011;26(1):78–81.

Schallreuter KU, Krüger C, Würfel BA, Panske A, Wood JM. From basic research to the bedside: Efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo. Int J Dermatol. 2008;47(7):743–53.

Schallreuter KU RH. Vitix--a new treatment for vitiligo? Int J Dermatol. 2005;44(11):969–70

Downloads

Published

02-07-2018

How to Cite

Diana, R., & Mulianto, N. (2018). Modalitas Terapi Topikal Vitiligo. Cermin Dunia Kedokteran, 45(7), 508–513. https://doi.org/10.55175/cdk.v45i7.750

Issue

Section

Articles