Hubungan Profil Laboratorium Sederhana dan Hipertensi di Fasilitas Kesehatan Tingkat Pertama Daerah Terpencil di Kabupaten Sikka, Flores, Nusa Tenggara Timur
DOI:
https://doi.org/10.55175/cdk.v45i1.833Keywords:
Hiperglikemia, hiperkolesterolemia, hipertensi, hiperurisemia, proteinuriaAbstract
Latar Belakang: Belum ada studi yang khusus menganalisis profil laboratorium sederhana, seperti pemeriksaaan gula darah, kolesterol, dan asam urat, menggunakan alat periksa cepat (multi-function monitor system) dan pemeriksaan proteinuria dengan urin dipstik pada pasien hipertensi di Nusa Tenggara Timur, Indonesia. Metode: Penelitian kasus-kontrol terhadap subjek terpilih secara consecutive sampling di tiga wilayah kerja puskesmas Kabupaten Sikka, Flores NTT, selama bulan Januari – Mei 2017. Dilakukan anamnesis, pemeriksaan fisik, serta penapisan pemeriksaan laboratorium sederhana menggunakan alat tes darah dan urin dipstik terhadap subjek usia >18 tahun. Data dianalisis dengan metode chisquare menggunakan SPSS 20. Hasil: Didapatkan 333 sampel terdiri dari 170 pasien hipertensi dan 163 pasien non-hipertensi. Pada umumnya didapatkan hiperurisemia, hiperglikemia, hiperkolesterolemia, dan proteinuria. Signifikansi klinis yang bermakna adalah temuan proteinuria, hiperkolesterolemia, serta hiperglikemia.
Background: No studies have specifically analyzed simple laboratory profiles including blood glucose, cholesterol, and uric acid examination using rapid blood monitoring device and proteinuria examination with dipstick urine among hypertensive patients in East Nusa Tenggara, Indonesia. Method: This case-control study was conducted in a consecutive sampling basis on subjects older than 18 years in three working areas at primary health care of Sikka Regency, Flores, NTT during January - May 2017. Data was collected from anamnesis, physical examination, and simple laboratory screening while using blood test kit and urine dipstick. Data was analysed with chi-square method, processed by SPSS 20. Results: We obtained 333 samples, consist of 170 hypertensive and 163 non-hypertensive patients. Hyperuricemia, hyperglycemia, hypercholesterolemia, and proteinuria were generally found. Clinical significance was for proteinuria, hyperlipidemia, and hyperglycemia.
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References
Perhimpunan Dokter Spesialis Kardiovaskular (PERKI). Pedoman Tatalaksana Hipertensi Pada Penyakit Kardiovaskular. 1st ed. Jakarta; 2015
Departemen Kesehatan RI. Riset Kesehatan Dasar (Riskerdas) [Internet]. 2013. Available from:https://www.google.com/search?q=riskerdas+hipertensi+2013&ie=utf-8&oe=utf-8&client=firefox-b-ab
Seran SB, Hala KK, Simanjuntak EMF, Hermanus L, Sinaga ME, Ralo T, et al. Profil kesehatan provinsi Nusa Tenggara Timur Tahun 2014. Dinas Kesehatan Propinsi NTT [Internet]. 2015 Juni 1 [cited 2017 Juli 2]. Available from: http://www.depkes.go.id/resources/download/profil/PROFIL_KES_PROVINSI_2014/19_NTT_2014.pdf
Kuwabara M. Hyperuricemia, cardiovascular disease and hypertension [Internet]. 2016. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865070/
Otsuka T, Takada H, Nishiyama Y, Kodani E, Saiki Y, kato K, et al. Dyslipidemia and the risk of developing hypertension in a working-age male population [Internet].2016. Available from: http://jaha.ahajournals.org/content/5/3/e003053
Beyer Mears A, Del Val M, Cruz E, Murray FT. Proteinuria associated with hypertension and diabetes mellitus [Internet]. 2010. Available from: https://www.ncbi.nlm.nih.gov/pubmed/3368505
Bakris G. Proteinuria. Hypertension 2015;46:473-74.
Bidani AK, Griffin KA. Pathophysiology of hypertensive renal damage. Hypertension 2014;44:595-601.
Agarwal R, Light RP. GFR, proteinuria and circadian blood pressure. Nephrol Dial Transplant. 2009;24(8):2400-6. doi: 10.1093/ndt/gfp074.
Herrick W. Hypertension and hyperglycemia [Internet]. 2017. Available from: http://jamanetwork.com/journals/jama/article-abstract/237290
Atarashi K, Ishiyama A, Minami M, Takagi M, Omata M. Effects of acute hypercholesterolemia on blood pressure and pressor response to norepinephrine in rats. Blood Press. 2004;13(1):56-61.
Puig JG, Torres RJ, Ruilope LM, Campo C, Grande C, Sancho T, et al. The pathophysiology of hyperuricemia in essential hypertension: A pilot study. Nucleosides Nucleotides Nucleic Acids. 2004;23(8-9):1197-9.
Krishnan E. Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009–2010. J Am Heart Assoc. 2014;3:e000157
Grayson P, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: A systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2011;63(1):102–10.
Lim D, Lee DY, Cho SH, Kim OZ, Cho SW, An SK, et al. Diagnostic accuracy of urine dipstick for proteinuria in older outpatients. Kidney Res Clin Pract. 2014;33(4):199-203. doi:10.1016/j.krcp.2014.10.003.
Salacinski AJ, Alford M, Drevets K, Hart S, Hunt BE. Validity and reliability of a glucometer against industry reference standards. J Diabetes Sci Technol. 2014;8(1):95-9
Firgiansyah A. Perbandingan kadar glukosa darah menggunakan spektrofotometer dan glukometer. 2016.
Inaccuracy of lipid measurements with the portable cholestech L·D·X analyzer in patients with hypercholesterolemia. Clin Chemistr. 2002;48 (2):284-90
Kuo CS, Hwu CM, Lin YH, Huang YH, Kao WY, Weih MJ, et al. Portable electrochemical blood uric acid meter. J Clin Lab Anal. 2002;16(2):109.
Zamanzad B. Accuracy of dipstick urinalysis as a screening method for detection of glucose, protein, nitrites and blood. East Mediterr Health J. 2009;15(5):1323-8.
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