Purified Cytoplasmic Pollen (PCP) Extract: A Novel Approach to The Treatment of Menopausal Symptoms
DOI:
https://doi.org/10.55175/cdk.v51i1.1006Kata Kunci:
Ekstrak purified cytoplasmic pollen, menopause, PCPAbstrak
Saat transisi ke masa menopause, beberapa gejala seperti nyeri otot dan sendi, nyeri punggung, gejala vasomotor, gejala urogenital, dan masalah psikologis dapat terjadi akibat penurunan kadar estrogen. Sekitar sepertiga wanita akan mengalami gejala berat yang memerlukan terapi. Saat ini, menopausal hormonal therapy (MHT) masih dianggap lini pertama, walaupun dengan risiko kanker. Pilihan lain seperti farmakoterapi atau obat-obatan herbal masih terbatas, sehingga masih dibutuhkan terapi yang efektif dan aman. Ekstrak purified cytoplasmic pollen (PCP) terstandar, juga dikenal dengan PureCyTonin® merupakan pilihan terapi baru non-hormonal, non-fitoestrogenik, yang telah terbukti efektif meredakan gejala menopause dan bersifat netral terhadap proliferasi dan apoptosis sel kanker payudara. Bukti terkini menunjukkan hasil yang menjanjikan bagi PureCyTonin® untuk terapi gejala menopause.
Unduhan
Referensi
Peacock K, Ketvertis KM. Menopause. Treasure Island (FL): StatPearls Publishing [Internet]. 2022 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507826/
Geraghty P, editor. Each woman’s menopause: An evidence based resource. 1st ed. Walnut Creek, California: Springer Nature; 2022.
Ji MX, Yu Q. Primary osteoporosis in postmenopausal women. Chronic Dis Transl Med. 2015;1:9-13.
D’Angelo S, Bevilacqua G, Hammond J, Zaballa E, Dennison EM, Walker-Bone K. Impact of menopausal symptoms on work: Findings from women in the health and employment after fifty (HEAF) study. Int J Environ Res Public Health 2023;20:295.
Boulet MJ, Oddens BJ, Lehert P, Vemer HM, Visser A. Climacteric and menopause in seven south-east Asian countries. Maturitas 1994;19(3):157-76. DOI: 10.1016/0378-5122(94)90068-x.
Calimbas KRC, Maceren-medina CIL. Assessment of climacteric symptoms among Filipino women ages 40 years and above seen at a tertiary hospital in Metro Manila. Phil J Obstet Gynecol. 2017;41:13-25.
Thapa R, Yang Y. Attitude toward and associating factors of menopause: A study on Cambodian women. Sage Open 2022;2022:1-15.
Kaunitz AM, Manson JAE. Management of menopausal symptoms. Obstet Gynecol. 2015;126:859-76.
Hickey M, Davis SR, Sturdee DW. Treatment of menopausal symptoms: What shall we do now? Lancet 2005;366:409-21.
Newhouser LM, Maneval M, Rayalam K, Sabeeh G, Varela L. SSRIs vs. SNRIs for vasomotor symptoms of menopause. Am Fam Physician 2022;105;430-1.
Wuttke W, Seidlová-Wuttke D. Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy. Clin Phytosci. 2015;1:12. DOI: 10.1186/s40816-015-0013-0.
Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, et al. Safety and efficacy of black cohosh and red clover for the managementof vasomotor symptoms: A randomized controlled trial. Menopause 2009;16:1156-66.
Teschke R, Schwarzenboeck A, Schmidt-Taenzer W, Wolff A, Hennermann K-H. Herb induced liver injury presumably caused by black cohosh: A survey of initially purported cases and herbal quality specifications. Ann Hepatol. 2011;10;249-59.
Franco DL, Kale S, Lam-Himlin DM, Harrison ME. Black cohosh hepatotoxicity with autoimmune hepatitis presentation. Case Rep Gastroenterol. 2017;11:23-8.
Genazzani AR, Adamyan L, Berga S, Birkhaeuser M, Brincat M, Cano A, et al. ISGE statement on purified and specific cytoplasmic pollen extract, PureCyTonin® as a non-hormonal alternative for the treatment of menopausal symptoms. Gynecol Reprod Endocrinol Metabol. 2022;3:70-3.
Fait T, Sailer M, Regidor PA. Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys® in the management of women with menopausal symptoms. Gynecological Endocrinology [Internet]. 2019. Available from: https://www.tandfonline.com/doi/full/10.1080/09513590.2018.1538347.
Appel K, Veit J, Diaz P, Palacios S. Purified and specific cytoplasmic pollen extract, PureCyTonin®, inhibits serotonin reuptake in the rat brain model. Gynecol Reprod Endocrinol Metabol. 2020;1:64-8.
Hellström AC, Muntzing J. The pollen extract Femal – A nonestrogenic alternative to hormone therapy in women with menopausal symptoms. Menopause 2012;19:825-9.
Winther K, Rein E, Hedman C. Femal, a herbal remedy made from pollen extracts, reduces hot flushes and improves quality of life in menopausal women: A randomized, placebo-controlled, parallel study. Climacteric 2005;8:162-70.
De Franciscis P, Conte A, Schiattarella A, Riemma G, Cobellis L, Colacurci N. Non-hormonal treatments for menopausal symptoms and sleep disturbances: A comparison between purified pollen extracts and soy isoflavones. Curr Pharm Des. 2020;26:4509-14.
Seeger H, Ruan X, Neubauer H, Brucker S, Mueck AO. Membrane-initiated effects of Serelys® on proliferation and apoptosis of human breast cancer cells. Gynecol Endocrinol [Internet]. 2017. Available from: https://www.tandfonline.com/doi/full/10.1080/09513590.2017.1407751.
Iop A, Driol P, Zacchia A, Miscoria M. Cytoplasmic pollen extract for treatment of menopausal symptoms in breast cancer patients: A case series report. Eur J Gynaecol Oncol. 2021;42:45-9.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2024 Lyon Clement
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
