Efektivitas Tetes Mata Citicoline terhadap Perbaikan Lapang Pandang dan Ketebalan Lapisan Serabut Saraf Retina pada Glaukoma Primer Sudut Terbuka
DOI:
https://doi.org/10.55175/cdk.v51i2.1046Kata Kunci:
Citicoline, glaukoma, tetes mataAbstrak
Glaukoma primer sudut terbuka (GPSTa) merupakan penyebab kedua terbesar kebutaan irreversible di seluruh dunia dan prevalensinya meningkat. Citicoline oral terbukti memiliki peran terhadap glaukoma, namun studi terkait tetes mata citicoline pada glaukoma masih terbatas. Dilakukan telaah kritis atas literatur terkait efektivitas citicoline dalam perbaikan mean deviation (MD) lapang pandang dan ketebalan lapisan serabut saraf retina (retinal nerve fiber layer/RNFL) pada GPSTa. Proses penelusuran literatur dilakukan pada 4 basis data, yaitu PubMed, Cochrane, Embase, dan Scopus. Dari 165 studi yang teridentifikasi awal, didapatkan 3 studi untuk proses telaah kritis. Studi Rossetti mendemonstrasikan perbedaan signifikan MD (p=0,02) dan RNFL (p=0,04) setelah pemberian tetes mata citicoline selama 3 tahun dibandingkan plasebo. Studi Mirachtsis menunjukkan setelah pemberian citicoline selama 3 bulan terdapat perbedaan signifikan RNFL (p=0,029), namun tidak ada perbaikan signifikan MD (p>0,05). Studi Parisi menunjukkan perbaikan MD pada pemberian citicoline 4 bulan (+0,56 dB) dan 6 bulan (+0,18 dB). Tetes mata citicoline memiliki potensi dalam menghambat progresivitas glaukoma dengan menghambat hilangnya RNFL, namun dalam hal perbaikan lapang pandang memerlukan studi lebih lanjut.
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