Tatalaksana Nyeri Neuropatik Perifer dengan Sediaan Patch
DOI:
https://doi.org/10.55175/cdk.v48i9.113Kata Kunci:
tatalaksana, manajemen, nyeri neuropatiAbstrak
Obat-obat oral seperti antidepresan trisiklik, antikonvulsan (gabapentin dan pregabalin), dan SSRI (selective serotonin reuptake inhibitors), masih menjadi pilihan pertama yang direkomendasikan oleh pedoman internasional dan Eropa untuk terapi nyeri neuropatik. Namun, penurunan nyeri hanya sebesar 30-40% dan sering disertai efek samping sistemik. Obat topikal sediaan patch menjadi salah satu terapi alternatif.
Oral drugs like tricyclic antidepressant, anticonvulsants (gabapentin and pregabalin), and SSRI (selective serotonin reuptake inhibitors), still become first choice as recommended by international and Europe therapy guidelines for neuropathic pain. However, the regimen is effective in only about 30-40% cases and often has undesirable systemic adverse effects. Topical drugs in patch form can be one of alternative therapy for neuropathic pain.
Unduhan
Referensi
Sommer C, Cruccu G. Topical treatment of peripheral neuropathic pain: Applying the evidence. J Pain Symptom Management. 2017;53:3
Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS et al. EFNS Guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010;17:1113-23.
Haanpaa M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152:14-27.
Mu A, Weiberg E, Moulin DE, Clarke H. Pharmacologic management of chronic neuropathic pain. Review of the Canadian Pain Society consensus statement. Canad Fam Phys. 2017;63:844-52.
Leppert W, Milewska MM, Zajaczkowska R, Wordliczek J. Transdermal and topical drug administration in the treatment of pain. Molecules. 2018;23:681.
Galves R, Navez ML, Moyle G, Maihofner C, Stoker M, Ernault E et al. Capsaicin 8% patch repeat treatment in nondiabetic peripheral neuropathic pain. Clin J Pain. 2017;33:921-31
Nooten Fv, Treur M, Pantiri K, Stoker M, Charokopou M. Capsaicin 8% patch versus oral neuropathic pain medications for the treatment of painful diabetic peripheral neuropathy: A systematic literature review and network meta-analysis. Clin Therapeut. 2017;39:4
Pergolizzi JV, Lequang JA. Lidocaine topical systems in the treatment of postherpetic neuralgia. EC Anaesthesia. 2019:239-51
Arai T, Kashimoto Y, Ukyo Y, Tominaga Y, Imanaka K. Two placebo-controlled, randomized withdrawal studies to evaluate the fentanyl 1 day patch in opioid-naïve patients with chronic pain. Curr Med Res Opin. 2015;31(12):2207-18
Simpson RW, Wlodarczyk JH. Transdermal buprenorphine relieves neuropathic pain: A randomized, double-blind, parallel-group, placebo-controlled trial in diabetic peripheral neuropathic pain. Diabetes Care. 2016;39:1493-500
Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth. 2011; 107(4): 490-502.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2021 Cermin Dunia Kedokteran
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
