Potensi Citicoline dalam Menghambat Penurunan Fungsi Kognitif pada Gangguan Kognitif Ringan
Laporan Kasus Berbasis Bukti
DOI:
https://doi.org/10.55175/cdk.v51i8.1210Kata Kunci:
Alzheimer, citicoline, kognitif, mild cognitive impairment, neurologisAbstrak
Latar Belakang: Penggunaan citicoline dikaitkan dengan perbaikan berbagai kondisi neurologis. Artikel ini bertujuan mengeksplorasi potensi citicoline untuk mencegah penurunan fungsi kognitif pasien mild cognitive impairment (MCI). Metode: Penelusuran literatur komprehensif melalui 10 database. Studi yang dipilih harus mencakup pasien dewasa dengan penurunan fungsi kognitif menggunakan citicoline. Seleksi artikel dengan kriteria inklusi dan eksklusi yang ditentukan. Selanjutnya dilakukan telaah kritis dan penilaian level of evidence. Hasil: Dari total 265 studi yang diperoleh, 15 studi dipilih dan dianalisis. Hasil menunjukkan bahwa citicoline memiliki potensi mencegah penurunan fungsi kognitif, baik pada pasien MCI, penyakit Alzheimer, penyakit Parkinson, stroke iskemik, maupun pada orang sehat. Walaupun hasilnya beragam, citicoline secara konsisten signifikan dikaitkan dengan peningkatan skor mini-mental state examination (MMSE) dan uji kognitif lainnya. Simpulan: Citicoline memiliki potensi mencegah penurunan fungsi kognitif pasien MCI. Dibutuhkan lebih banyak penelitian untuk memahami efek jangka panjang dan mekanisme kerja citicoline.
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