Peran Vitamin D pada Fungsi Sawar Permeabilitas Kulit
DOI:
https://doi.org/10.55175/cdk.v48i10.139Kata Kunci:
fungsi sawar kulit, epidermis, vitamin DAbstrak
Salah satu fungsi utama kulit adalah membentuk sawar antara tubuh dan lingkungan eksternal. Fungsi sawar permeabilitas kulit salah satunya dipertahankan dengan proses diferensiasi dan proliferasi keratinosit pada lapisan epidermis. Efek vitamin D pada kulit termasuk memengaruhi proliferasi, diferensiasi, dan apoptosis keratinosit. Defisiensi serta kelainan aktivasi dan metabolisme vitamin D menyebabkan defek fungsi sawar permeabilitas kulit. Makalah ini membahas epidermis sebagai sawar permeabilitas kulit dan peran vitamin D pada sawar permeabilitas kulit.
One of the skin’s main functions is to form a protective barrier towards external environment. The protective function is maintained by differentiation and proliferation of keratinocytes in the epidermal layer. Vitamin D effects on the skin include proliferation, differentiation, and apoptosis of keratinocyte. Deficiency and abnormalities of vitamin D activation and metabolism impair skin’s function as permeability barrier. This paper discusses the epidermis as permeability barrier and the role of vitamin D in the skin permeability barrier.
Unduhan
Referensi
Kubo A, Amagai M. Skin barrier. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringeeds JS, editors. Fitzpatrick’s dermatology in general medicine. 9th ed. vol 1. New York: McGraw Hill, 2019 .p. 206-31
Del Rosso JQ, Zeichner J, Alexis A, Cohen D, Berson D. Understanding the epidermal barrier in healthy and compromised skin: Clinically relevant information for the proceedings of an expert panel roundtable meeting. J Clin Aesthet Dermatol. 2016;9:2-8.
Gerritsen M, Van de Kerkhof P, Langner A. Long–term safety of topical calcitriol 3 μg g− 1 ointment. Br J Dermatol. 2001;144(58):17-9
Reichrath J, Zouboulis CC, Vogt T, Holick MF. Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook. Rev Endocr Metab Disord. 2016;17(3):405-17.
Kim GK. The rationale behind topical vitamin D analogs in the treatment of psoriasis: Where does topical calcitriol fit in? J Clin Aesthet Dermatol. 2010;3(8):46
Oh JS, Jang HH. Epidermal differentiation and skin barrier. Asian J Beauty Cosmetol. 2015;13:13-720
Kim HJ, Jeong SK. New trends in skin barrier research. J Skin Barrier Res. 2012;14:15-28
Hong SP. Assessment of skin barrier function and moisturizer efficacy. J Skin Barrier Res. 2014;16:56-63,
Jeong SK, Kim HJ, Park BD, Lee SH. Skin barrier and lipids. J Skin Barrier Res. 2009;11:13-27
Shahriari M, Kerr PE, Slade K, Grant-Kels JE. Vitamin D and the skin. Clin Dermatol. 2010;28(6):663-8.
Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, et al. Extrarenal expression of 2hydroxyvitamin D(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 2001;86:888–94.
Bikle D. Vitamin D metabolism and function in the skin. Else. 2011;347:80–9
Bikle D. Vitamin D regulated keratinocyte differentiation. J Cell Biochemistr. 2004; 92(3):436–44.
Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu Cl. Disruption of vitamin D and calcium signaling in keratinocytes predisposes to skin cancer. Front Physiol. 2016;7:296.
Cornelissen LH, Oomens CW, Huyghe JM, Baaijens FP. Mechanisms that play a role in the maintenance of the calcium gradient in the epidermis. Skin Res Technol. 2007;13(4):369-76.
Umar M, Sastry KS, Ali FA, Al-Khulaifi M, Wang E, Chouchane AI. Vitamin D and the pathophysiology of inflammatory skin diseases. Skin Pharmacol Physiol. 2018;31(2):74
Roider E, Ruzicka T, Schauber J. Vitamin D, the cutaneous barrier, antimicrobial peptides and allergies: Is there a link? Allerg Asthma Immunol Res. 2013;5(3):119-28.
Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol. 2009;129:1367-78.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2021 Cermin Dunia Kedokteran
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
