Konjungtivitis pada COVID-19
DOI:
https://doi.org/10.55175/cdk.v48i11.142Kata Kunci:
konjungtivitis, COVID-19Abstrak
Corona Virus Disease 19 (COVID-19) pertama ditemukan di Wuhan, Cina, pada Desember 2019 dan telah menjadi ancaman kesehatan global. COVID-19 disebabkan oleh Severe Acute Respiratory Corona Virus 2 (SARS-CoV-2), ditransmisikan melalui droplet pernapasan atau kontak erat. Penelitian terbaru menyatakan bahwa konjungtiva dapat menjadi port d’entree SARS-CoV-2, dan menyebabkan gejala konjungtivitis. Jalur transmisi SARS-CoV 2 ke okuler diduga melalui inokulasi langsung dan melalui reseptor ACE2 yang diekspresikan di konjungtiva. Karakteristik konjungtivitis COVID-19 adalah sekret mukoid ataupun aqueous berlebih, sensasi tidak nyaman pada okuler seperti gatal, benda asing, atau rasa terbakar, serta hiperemis konjungtiva. Pada pemeriksaan RT PCR swab okuler ataupun nasofaring dapat positif pada 3 hingga 21 hari setelah onset gejala. Studi ini merupakan literature review. Artikel diambil dari database Google scholar, Pubmed, Lange, Elsevier, dengan kata kunci “ocular manifestation in COVID-19”, “characteristics of conjunctivitis in COVID-19”, “mechanism of COVID-19 in conjunctiva”. Artikel yang dipilih adalah jurnal yang dipublikasi sejak tanggal 1 Desember 2019 sampai 30 Oktober 2020.
Corona Virus Disease 19 (COVID-19) was first discovered in Wuhan, China, in 2019 and has been declared as global health emergency. COVID-19 is caused by Severe Acute Respiratory Corona Virus 2 (SARS-CoV 2) transmitted through droplet and physical contact. Studies stated that conjunctiva is a potential port of entry of SARS-CoV2, which then leads to conjunctivitis. This literature review is based on analytic study on conjunctivitis in COVID-19. The transmission route is thought from direct inoculation and expression of ACE2 receptors from conjunctiva. Most common characteristics of conjunctivitis in COVID-19 are increased conjunctival secretions both mucoid and aqueous, and ocular discomfort such as itching, foreign bodies sensations, burning, and conjunctival hyperemia. RT PCR from both ocular and nasopharyngeal swabs were detectable from days 3 to 21 after the onset of symptoms. This study is a review on published articles from December 1st 2019 to October 30th 2020, in Google Scholar, PubMed, Lange, and Elsevier; selected with keywords “ocular manifestation in COVID-19”, “characteristics of conjunctivitis in COVID-19”, “mechanism of COVID-19 in conjunctiva”.
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Shemer A, Einan-Lifshitz A, Itah A, Dubinsky-Pertzov B, Pras E, Hecht I. Ocular involvement in coronavirus disease 2019 (COVID-19): A clinical and molecular analysis. Int Ophthalmol [Internet]. 2020 Sep 14 [cited 2020 Sep 30]. Available from: https://doi.org/10.1007/s10792-020-01592-1
Sarma P, Kaur H, Kaur H, Bhattacharyya J, Prajapat M, Shekhar N, et al. Ocular manifestations and tear or conjunctival swab PCR positivity for 2019-nCoV in patients with COVID-19: A systematic review and meta-analysis. SSRN Journal [Internet]. 2020 [cited 2020 Oct 9]. Available from: https://www.ssrn.com/abstract=3566161
Lu C, Liu X, Jia Z. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 2020;395(10224):39.
Belser JA, Rota PA, Tumpey TM. Ocular tropism of respiratory viruses. Microbiol Mol Biol Rev. 2013;77(1):144–56.
Hu K, Patel J, Patel BC. Ophthalmic Manifestations of coronavirus (COVID-19). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 [cited 2020 Sep 14]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK556093/
Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, et al. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: A cross-sectional study. Acta Ophthalmologica [Internet]. [cited 2020 Sep 20];n/a(n/a). Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.14472
Ho D, Low R, Tong L, Gupta V, Veeraraghavan A, Agrawal R. COVID-19 and the ocular surface: A review of transmission and manifestations. Ocular Immunology and Inflammation. 2020;28(5):726–34.
Pardhan S, Vaughan M, Zhang J, Smith L, Chichger H. Sore eyes as the most significant ocular symptom experienced by people with COVID-19: A comparison between pre-COVID-19 and during COVID-19 states. BMJ Open Ophthalmol. 2020;5(1):e000632.
Xie Y, Karki C, Du D, Li H, Wang J, Sobitan A, et al. Spike proteins of SARS-CoV and SARS-CoV-2 utilize different mechanisms to bind with human ACE2. Frontiers in Molecular Biosciences. 2020;7.
Liang L, Wu P. There may be virus in conjunctival secretion of patients with COVID-19. Acta Ophthalmol [Internet]. 2020 Mar 18 [cited 2020 Sep 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228356/
Lange C, Wolf J, Auw-Haedrich C, Schlecht A, Boneva S, Lapp T, et al. Expression of the COVID-19 receptor ACE2 in the human conjunctiva. J Med Virol. 2020;92(10):2081–6.
Colavita F, Lapa D, Carletti F, Lalle E, Bordi L, Marsella P, et al. SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. Ann Intern Med. 2020;173(3):242–3.
Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol [Internet]. 2020 Mar 12 [cited 2020 Sep 20]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228294/
Peng Y, Zhou Y. Is novel coronavirus disease (COVID-19) transmitted through conjunctiva? J Med Virol [Internet]. 2020 Mar 16 [cited 2020 Sep 20]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228239/
Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, et al. Characteristics of ocular findings of patients with Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;138(5):575–8.
Scalinci SZ, Trovato Battagliola E. Conjunctivitis can be the only presenting sign and symptom of COVID-19. IDCases. 2020;20:e00774.
Güemes-Villahoz N, Burgos-Blasco B, García-Feijoó J, Sáenz-Francés F, Arriola-Villalobos P, Martinez-de-la-Casa JM, et al. Conjunctivitis in COVID-19 patients: Frequency and clinical presentation. Graefes Arch Clin Exp Ophthalmol [Internet]. 2020 Aug 29 [cited 2020 Sep 15]. Available from: https://doi.org/10.1007/s00417-020-04916-0
Güemes-Villahoz N, Burgos-Blasco B, Arribi-Vilela A, Arriola-Villalobos P, Rico-Luna CM, Cuiña-Sardiña R, et al. Detecting SARS-CoV-2 RNA in conjunctival secretions:Is it a valuable diagnostic method of COVID-19? Journal of Medical Virology [Internet]. [cited 2020 Oct 10];n/a(n/a). Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.26219
Ma N, Li P, Wang X, Yu Y, Tan X, Chen P, et al. Ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19 in Wuhan, China.JAMA Ophthalmol. 2020;138(10):1079.
Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol [Internet]. 2020 Mar 12 [cited 2020 Sep 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228294/
Xie HT, Jiang SY, Xu KK, Liu X, Xu B, Wang L, et al. SARS-CoV-2 in the ocular surface of COVID-19 patients. Eye and Vis. 2020;7(1):23.
Corona virus disease-19 (COVID-19) presenting as conjunctivitis: Atypically high-risk during a pandemic - Contact Lens and Anterior Eye [Internet]. [cited 2020 Oct 7]. Available from: https://www.contactlensjournal.com/article/S1367-0484(20)30083-7/fulltext
Zhou Yunyun, Zeng Yuyang, Tong Y. Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva. 2020 Feb 12 [cited 2020 Oct 7]. Available from: https://europepmc.org/article/ppr/ppr112623
Seah I, Anderson D, Kang A, Wang L, Rao P, Young B, et al. Assessing viral shedding and infectivity of tears in Coronavirus Disease 2019 (COVID-19) Patients. Ophthalmology. 2020;127(7):977-9.
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