Eritroderma Diduga Akibat Reaksi Obat Allopurinol: Laporan Kasus
Laporan Kasus
DOI:
https://doi.org/10.55175/cdk.v52i9.1513Kata Kunci:
Allopurinol, eritroderma, DRESS, laporan kasus, reaksi obatAbstrak
Latar Belakang: Eritroderma adalah suatu kondisi eritema seluruh tubuh disertai pengelupasan kulit. Hal ini telah dikaitkan dengan sindrom DRESS dan berpotensi mengancam jiwa. Kasus: Wanita berusia 55 tahun dengan eritema generalisata, pruritus, malaise, dan edema wajah sejak 7 hari. Pasien memiliki riwayat diabetes melitus tipe 2 dan dalam pengobatan allopurinol oral selama 2 minggu terakhir. Plak eritematosa umum yang luas dan sisik hiperkeratosis didapatkan di wajah, leher, dada, lengan, kaki, punggung, dan bokong. Pemeriksaan laboratorium menunjukkan eosinoflia, hipoalbuminemia ringan, hiperglikemia, dan peningkatan kadar enzim hepar. Diskusi: Eritroderma merupakan kasus emergensi dibidang kulit dan memerlukan terapi dan perawatan di rumah sakit. Pasien eritroderma akibat reaksi obat yang memiliki keterlibatan organ dalam dikaitkan dengan sindrom DRESS dan memerlukan observasi status jantung, ginjal, dan hepar. Simpulan: Allopurinol berpotensi menyebabkan eritroderma.
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