Terapi CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats): Pengenalan untuk Penggunaan Klinis

Penulis

  • Cipta Mahendra Departemen Kimia-Biokimia, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia

DOI:

https://doi.org/10.55175/cdk.v48i11.152

Kata Kunci:

CRISPR, genetik, medis, terapi

Abstrak

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) mulai mendapat perhatian saat Jennifer Doudna dan Emmanuelle Charpentier mendapat hadiah Nobel bidang Kimia tahun 2020 lalu. Meskipun relatif merupakan terobosan baru, terapi CRISPR memiliki potensi besar di bidang medis. Tinjauan ini merupakan pengantar untuk mengenal dan memahami CRISPR sebagai sebuah upaya terapi alternatif di masa depan.

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) starts to gain attention when Jennifer Doudna and Emmanuelle Charpentier were awarded Nobel Prize in Chemistry in 2020. CRISPR is relatively a new discovery in science, but it has a great potential in medicine. This review is to give an overview on CRISPR as a promising medical therapy.

Unduhan

Data unduhan belum tersedia.

Referensi

Schmidt DMT, Lo TW. Molecular biology at the cutting edge: A review on CRISPR/CAS9 gene editing for undergraduates. Biochem Mol Biol Educ. 2018;46(2):195-205.

Lino CA, Harper JC, Carney JP, Timlin JA. Delivering CRISPR: A review of the challenges and approaches. Drug Delivery 2018;25(1):1234-57.

Xu Y, Li Z. CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy. Comput Struct Biotechnol J. 2020;18:2401-15.

Wang H, Russa ML, Qi LS. CRISPR/Cas9 in genome editing and beyond. Ann Rev Biochem. 2016;85(22):1-38.

Eid A, Mahfouz MM. Genome editing: The road of CRISPR/Cas9 from bench to clinic. Exp Mol Med. 2016;48(10):265.

Mittal RD. Gene editing in clinical practice: Where are we? Ind J Clin Biochem. 2019;34(1):19-25.

Higashijima Y, Hirano S, Nangaku M, Nureki O. Applications of the CRISPR-Cas9 system in kidney research. Kidney Int. 2017;92(2):324-35.

Kaszkiel EK, Juranek J, Maksymowicz W, Wojtkiewicz J. CRISPR/Cas9 technology as an emerging tool for targeting amyotrophic lateral sclerosis (ALS). Int J Mol Sci.2018;19(3):906-18.

Sekar D, Lakshmanan G, Biruntha M. Implications of CRISPR/Cas9 system in hypertension and its related diseases. J Hum Hypertens. 2021;35(7):642-4.

Li Y, Song YH, Liu B, Yu XY. The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research. Int J Cardiol. 2017;227:191-3.

Khan MNM, Islam KK, Ashraf A, Barman NC. A review on genome editing by CRISPR-Cas9 technique for cancer treatment. World Cancer Res J. 2020;7:1510.

Khalil AM. The genome editing revolution: A review. J Genet Eng Biotechnol. 2020;18(1):68-83.

Diterbitkan

2021-11-01

Cara Mengutip

Mahendra, C. (2021). Terapi CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats): Pengenalan untuk Penggunaan Klinis. Cermin Dunia Kedokteran, 48(11), 369–371. https://doi.org/10.55175/cdk.v48i11.152