Efikasi Statin pada Tata Laksana Oftalmopati Graves
Analisis
DOI:
https://doi.org/10.55175/cdk.v52i7.1546Kata Kunci:
Kolesterol, oftalmopati Graves, penatalaksanaan, penyakit autoimun tiroid, statinAbstrak
Oftalmopati Graves (OG) merupakan manifestasi klinis penyakit autoimun tiroid pada mata. Terjadinya inflamasi dan remodelling jaringan penyakit OG dapat menyebabkan keluhan ringan hingga berat yang bisa merusak saraf pada mata dan berujung pada kebutaan. Identifikasi dini diagnosis, klasifikasi aktivitas dan derajat keparahan penyakit, serta faktor risiko penyakit diperlukan. Hal ini dapat membantu penatalaksaan lanjutan yang komprehensif guna mencegah kerusakan berat dan permanen. Faktor endogen (tidak dapat dimodifikasi), eksogen (dapat dimodifikasi), dan lingkungan berinteraksi secara kompleks sebagai faktor risiko OG. Hiperkolestrolemia yang juga disebabkan oleh adanya inflamasi sistemik jangka panjang, menjadi salah satu faktor risiko yang diyakini berhubungan dengan OG. Hal ini dapat diatasi salah satunya dengan pemberian obat-obatan golongan statin. Selain berperan untuk menurunkan kadar kolesterol di dalam darah, statin juga memiliki efek preventif dan terapeutik pada pasien OG terutama pada pasien dengan klasifikasi OG aktif derajat sedang-berat. Statin juga memiliki efek pleiotropik, berperan sebagai imunoregulator, bekerja dengan menghambat adipogenesis serta bersinergi dengan terapi methylprednisolone pada penatalaksanaan OG.
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Referensi
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