Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non-Formularium Nasional
DOI:
https://doi.org/10.55175/cdk.v48i12.173Kata Kunci:
Formularium Nasional, obat antiskabies, skabiesAbstrak
Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Di antara sebelas faktor yang bisa memengaruhi prevalensi skabies di komunitas, salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional, yaitu permethrin dan salep 2–4, dengan Non-Formularium Nasional seperti benzyl benzoate, ivermectin, gamma benzene hexachloride, crotamiton, dan Tinospora cordifolia. Metode penelitian ini adalah scoping review dari September 2020–Desember 2020. Pencarian sistematis melalui database elektronik PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane sesuai kriteria inklusi dan eksklusi; skrining menggunakan kriteria PICOS (Patient, Intervention, Comparison, Outcome, dan Study). Hasil pencarian adalah 15 artikel; 11 artikel menunjukkan bahwa permethrin memiliki cure rate lebih tinggi daripada benzyl benzoate, ivermectin, gamma benzene hexachloride, dan crotamiton. Dua artikel menunjukkan ivermectin memiliki cure rate lebih tinggi daripada lindane dan sulfur. Satu artikel menunjukkan terapi kombinasi sulfur lebih baik daripada terapi tunggal. Satu artikel menunjukkan bahwa Tinospora cordifolia memiliki cure rate yang tinggi. Disimpulkan bahwa permethrin sebagai salah satu obat antiskabies yang terdapat di Formularium Nasional, memiliki cure rate lebih tinggi daripada obat-obat antiskabies Non-Formularium Nasional.
Scabies is the third most common skin disease in Indonesia; it is caused by Sarcoptes scabiei var hominis mite. This study aims to compare the cure rate of antiscabietic drugs in the National Formulary, namely permethrin and 2–4 ointment with the Non-National Formularies such as benzyl benzoate, ivermectin, gamma benzene hexachloride, crotamiton, and Tinospora cordifolia. The systematic search was done in September 2020–December 2020 from electronic databases i.e. PubMed, Science Direct, Springerlink, Google Scholar, and Cochrane; using the inclusion and exclusion criteria and PICOS (Patient, Intervention, Comparison, Outcome, and Study) criteria, The search resulted in 15 articles; 11 articles show that permethrin has better cure rate than benzyl benzoate, ivermectin, gamma benzene hexachloride, and crotamiton. Two articles show that Ivermectin has higher cure rate than lindane and sulfur. One article suggests sulfur combination therapy is preferable to single therapy. One article shows that Tinospora cordifolia has a high cure rate. The conclusion is that permethrin as one of antiscabietic drug in National Formulary has higher cure rate than Non-National Formulary antiscabietic drugs.
Unduhan
Referensi
Mading M, Indriaty I. Kajian aspek epidemiologi skabies pada manusia. J Penyakit Bersumber Binatang. 2015;2(2):9–18.
World Health Organization. Scabies and other ectoparasites [Internet]. Neglected tropical diseases. Available from: https://www.who.int/water_sanitation_health/diseases-risks/diseases/scabies/en/
Putri YY, Dewi R, Astuti I, Bhatara T. Karakteristik tanda kardinal penyakit skabies pada santri di Pesantren. J Integ Kes Sains. 2020;2(3):126–9.
World Health Organization. Water-related diseases. Water sanitation hygiene [Internet]. Available from: https://www.who.int/water_sanitation_health/diseasesrisks/diseases/scabies/en/
Naftassa Z, Putri TR. Hubungan jenis kelamin, tingkat pendidikan dan pengetahuan terhadap kejadian skabies pada santri Pondok Pesantren Qotrun Nada Kota Depok. Biomedika. 2018;10(2):115–9.
Heukelbach J, Feldmeier H. Scabies. Lancet 2006;367(9524):1767–74.
Handayani N, Ikaditya L. Analisis biaya efektif terapi skabies permetrin 5% dan salep 2-4. Media Inf. 2020;15(2):89–95.
Indonesia MKR. KEPMENKES Nomor HK.01.07/MENKES/813/2019 tentang Formularium Nasional [Internet]. 2019. Available from: https://iaijatim.id/kmk-no-hk-01-07-menkes-813-2019-ttg-formularium-nasional/
Khalil S, Abbas O, Kibbi AG, Kurban M. Scabies in the age of increasing drug resistance. PLoS Negl Trop Dis. 2017;11(11):1–10.
Chhaiya SB, Patel VJ, Dave JN, Mehta DS, Shah HA. Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies. Indian J dermatology, Venerol Leprol. 2012;78(5):605–10.
Rao MA, Raza N, Faheem M, Saleem MA. Comparison of efficacy of permethrin 5% cream with crotamiton 10% cream in patients with scabies. J Ayub Med Coll Abbottabad. 2019;31(2):230–2.
Meenakshi M, Sadhna K, Neeraj S, Deepak V, Renu P. An open label, randomized, comparative study of antiscabietic drugs permethrin, gamma benzene hexachloride and ivermectin in patients of uncomplicated scabies. Int J Pharmacol Clin Sci [Internet]. 2014;3(2):15–21.
Alipour H, Goldust M. The efficacy of oral ivermectin vs. sulfur 10% ointment for the treatment of scabies. Ann Parasitol. 2015;61(2):79–84.
Ranjkesh MR, Naghili B, Goldust M, Rezaee E. The efficacy of permethrin 5% vs. oral ivermectin for the treatment of scabies. Ann Parasitol. 2013;59(4):189–94.
Sharma R, Singal A. Topical permethrin and oral ivermectin in the management of scabies: A prospective, randomized, double blind, controlled study. Indian J dermatology, Venerol Leprol. 2011;77(5):581–6.
Pourhasan A, Goldust M, Rezaee E. Treatment of scabies, permethrin 5% cream vs. crotamiton 10% cream. Ann Parasitol. 2013;59(3):143–7.
Mila-Kierzenkowska C, Woźniak A, Krzyzyńska-Malinowska E, Kałuzna L, Wesołowski R, Poćwiardowski W, et al. Comparative efficacy of topical pertmehrin, crotamiton and sulfur ointment in treatment of scabies. J Arthropod Borne Dis. 2017;11(1):1–9.
Zaelany AI, Astuti ISW, Sutejo IR. Comparison of the effectiveness of 10% sulfur soap and 2-4 ointment as single treatment. J Agromedicine Med Sci. 2017;3(3):19.
Goldust M, Rezaee E, Raghifar R, Naghavi-Behzad M. Ivermectin vs. lindane in the treatment of scabies. Ann Parasitol. 2013;59(1):37–41.
Goldust M, Rezaee E, Raghifar R, Hemayat S. Treatment of scabies: The topical ivermectin vs. permethrin 2.5% cream. Ann Parasitol. 2013;59(2):79–84.
Goldust M, Rezaee E, Raghifar R, Naghavi-Behzad M. Comparison of permethrin 2.5 % cream vs. Tenutex emulsion for the treatment of scabies. Ann Parasitol. 2013;59(1):31–5.
Chitti Babu G, Bagati KD, Agarwal P, Sharda S. A comparative study to assess the efficacy of permethrin (topical) and ivermectin (oral) in scabies patients seeking care at a tertiary care teaching hospital of Northern India. Int J Res Pharm Sci. 2020;11(1):1155–9.
Chitti Babu G, Bagati KD, Agarwal P, Sharma J. A comparative study to assess the efficacy of permethrin (topical) and benzyl benzoate (topical) for the treatment of scabies patients. Int J Res Pharm Sci. 2019;10(4):3688–93.
Castillo AL, Osi MO, Ramos JDA, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2013;4(1):39–46.
Romani L, Whitfeld MJ, Koroivueta J, Kama M, Wand H, Tikoduadua L, et al. Mass drug administration for scabies control in a population with endemic disease. N Engl J Med. 2015;373(24):2305–13.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2021 Cermin Dunia Kedokteran
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.
