Onikomikosis yang Disebabkan oleh Kodamaea ohmeri pada Seorang Pasien dengan Virus Imunodefisiensi Manusia (HIV) – Laporan Kasus
Laporan Kasus
DOI:
https://doi.org/10.55175/cdk.v53i07.1895Kata Kunci:
Laporan kasus, infeksi jamur pada kuku, HIV, Kodamaea ohmeri, onikomikosisAbstrak
Pendahuluan: Onikomikosis adalah infeksi jamur pada kuku yang umumnya disebabkan oleh dermatofita. Kodamaea ohmeri merupakan jamur langka yang saat ini dilaporkan dapat menyebabkan onikomikosis dan infeksi sistemik. Jamur mirip ragi ini sering salah diidentifikasi sebagai Candida sp. Identifikasi yang lengkap diperlukan untuk mendapatkan hasil yang akurat. Kasus: Laki-laki berusia 40 tahun dengan HIV berobat dengan keluhan kuku jari kedua tangan berwarna kuning dan rapuh sejak 2 bulan. Dilakukan pemeriksaan KOH dari kerokan kuku dilanjutkan dengan biakan jamur. Isolat diidentifikasi secara paralel menggunakan Integral System Yeast Plus, Vitek-2, MALDI- TOF (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry), serta sekuensing, dan diperoleh hasil Kodamaea ohmeri. Pasien mendapat antijamur itraconazole oral dan ketoconazole topikal. Pembahasan: Onikomikosis pada pasien HIV disebabkan oleh imunitas rendah, viral load tinggi, serta nilai CD4 yang rendah. Pada kasus ini, hasil sediaan KOH dan biakan jamur menunjukkan morfologi menyerupai Candida sp. Pada kasus ini, K. ohmeri berhasil diidentifikasi menggunakan Vitek-2, MALDI-TOF, dan sekuensing area ITS (Internal Transcribed Spacer), sementara Integral System Yeast Plus dalah mengidentifikasi isolat tersebut sebagai Candida tropicalis. Secara klinis, tampak perbaikan pada kuku setelah pengobatan. Simpulan: Kodamaea ohmeri dapat menjadi patogen onikomikosis pada pasien HIV. Identifikasi K.ohmeri dapat dikerjakan dengan Vitek-2 dan MALDI-TOF.
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Referensi
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Hak Cipta (c) 2026 Ardiana Kusumaningrum, Siti Nadliroh, mardiastuti wahid, Fithriyah Sjatha, Cliff Clarence Haliman, Sandra Widaty, Robiatul Adawiyah, Rizkia Chairani, Aditya Pratama, Rizka Mutiara
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